Photodynamic therapy and fluorescent diagnostics of skin cancer with radochlorine and photosense: comparing efficacy and toxicity

2004 ◽  
Author(s):  
Elena G. Vakulovskaya ◽  
Yuriy V. Kemov ◽  
Igor D. Zalevsky ◽  
Andrew V. Reshetnikov ◽  
Loubov V. Umnova ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Skin Cancer

Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: An international consensus

2007 ◽  
Vol 56 (1) ◽  
pp. 125-143 ◽  
Author(s):  
Lasse R. Braathen ◽  
Rolf-Markus Szeimies ◽  
Nicole Basset-Seguin ◽  
Robert Bissonnette ◽  
Peter Foley ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Skin Cancer ◽  
Nonmelanoma Skin Cancer ◽  
International Consensus

scholarly journals Pathophysiological justification of the use of photodynamic therapy in the initial stage of squamous cell skin cancer

2021 ◽  
Vol 67 (1) ◽  
pp. 77-84
Author(s):  
Vladimir Masljakov ◽  
Dmitry Grebnev ◽  
Larisa Kim
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Treatment ◽  
Skin Cancer ◽  
Matrix Metalloproteinases ◽  
Squamous Cell ◽  
Therapy Group ◽  
Combined Treatment ◽  
Vascular Wall ◽  
Comprehensive Treatment ◽  
Initial Stage

The work is based on an analysis of the course of the disease in 185 patients with squamous cell skin cancer. The study program included studies in three major groups. The first included 74 (40%) patients who underwent combined treatment: an operation involving widespread excision of a tumor under intravenous anesthesia + photodynamic therapy (group 1). The second group was 111 (60%) patients with squamous cell carcinoma of the skin who received only operative treatment. To control and compare the obtained laboratory indicators, a second group was created, which included patients without established pathology. This group included 17 people who voluntarily agreed to conduct the study. The study traced the dynamics of changes in hemostasis scores and metalloproteinases in the two groups being compared. In the group of patients with squamous cell skin cancer, there was a statistically significant decrease in the metalloproteinase-1 inhibitor index, which led to an increase in all metalloproteinase-2, -7 and -9 indicators. Performing surgical treatment did not lead to correction of these indicators, both in the near and distant periods after treatment. The mechanism of influence of photodynamic therapy in squamous cell skin cancer can be characterized as follows: there is a decrease in the inhibitor of metalloproteinase-1, which leads to an increase in matrix metalloproteinases-2, -7 and -9 in the blood, as a result of damage to the endothelium of the vascular wall, which is confirmed by an increase in endothelin, this, in turn, led to the development of vasoconstriction and increased procoagulant activity The use of photodynamic therapy restores the index of metalloproteinase-1 inhibitor, this leads to the restoration of matrix metalloproteinases-2, -7 and -9 in the blood and the prevention of damage to the vascular wall. Comprehensive treatment of patients with squamous cell skin cancer in the initial stage of the disease should include photodynamic therapy with simultaneous intravenous blood irradiation, laser tumor training, and then surgical treatment, consisting in excision of the tumor with observance of oncological principles.

Photodynamic Therapy: Basic Principles and Applications to Skin Cancer

2002 ◽  
pp. 443-451
Author(s):  
Sol Kimel ◽  
Genady Kostenich ◽  
Arie Orenstein
Keyword(s):  
Photodynamic Therapy ◽  
Skin Cancer ◽  
Basic Principles

Vitamin D as a potential enhancer of aminolevulinate-based photodynamic therapy for nonmelanoma skin cancer

2010 ◽  
Author(s):  
Edward V. Maytin ◽  
Sanjay Anand ◽  
Natasha Atanaskova ◽  
Clara Wilson
Keyword(s):  
Vitamin D ◽  
Photodynamic Therapy ◽  
Skin Cancer ◽  
Nonmelanoma Skin Cancer
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