Stably transfected human cell lines as fluorescent screening assay for nuclear factor KB activation dependent gene expression

2004 ◽  
Author(s):  
Christine E. Hellweg ◽  
Christa Baumstark-Khan ◽  
Gerda Horneck
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Human Cell ◽  
Nuclear Factor ◽  
Human Cell Lines ◽  
Screening Assay ◽  
Nuclear Factor Kb

NTP-mediated changes of gene expression patterns in human cell lines

2013 ◽  
Author(s):  
Lena Bundscherer ◽  
Anke Schmidt ◽  
Annemarie Barton ◽  
Sybille Hasse ◽  
Kristian Wende ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Human Cell ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Human Cell Lines

Gene expression of human squamous cell carcinoma antigens 1 and 2 in human cell lines

2001 ◽  
Author(s):  
Katsuyuki Hamada ◽  
Yasushi Hanakawa ◽  
Koji Hashimoto ◽  
Mari Iwamoto ◽  
Toshimasa Kihana ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Human Cell ◽  
Human Cell Lines ◽  
Human Squamous Cell Carcinoma

Kinetics of gene expression following exposure to 60 Hz, 2 mT magnetic fields in three human cell lines

1997 ◽  
Vol 43 (1) ◽  
pp. 1-6 ◽  
Author(s):  
George H. Harrison ◽  
Elizabeth K. Balcer-Kubiczek ◽  
Zhong-Ming Shi ◽  
Yiao-Feng Zhang ◽  
Welton A. McCready ◽  
...  
Keyword(s):  
Gene Expression ◽  
Magnetic Fields ◽  
Cell Lines ◽  
Human Cell ◽  
Human Cell Lines ◽  
Kinetics Of

Altered gene expression during cellular aging

Genome ◽  
1989 ◽  
Vol 31 (1) ◽  
pp. 386-389 ◽  
Author(s):  
James R. Smith ◽  
Olivia M. Pereira-Smith
Keyword(s):  
Gene Expression ◽  
Dna Synthesis ◽  
Cell Lines ◽  
Cellular Senescence ◽  
Human Cell ◽  
Messenger Rna ◽  
Human Cells ◽  
Cellular Aging ◽  
Human Cell Lines ◽  
Normal Human

The limited division potential of normal human diploid fibroblasts in culture represents a model system for cellular aging. Observations indicate cellular senescence is an active process. Senescent cells, although unable to divide, are actively metabolizing. Hybrids from fusion of normal and immortal human cells exhibit limited division potential, suggesting that the phenotype of cellular senescence is dominant and supporting the hypothesis that senescence is genetically programmed. Fusion of immortal human cell lines with each other has identified four complementation groups for indefinite division. This indicates that a limited number of specific genes or processes are involved in senescence. Senescent cells express highly abundant DNA synthesis inhibitory messenger RNAs and produce a surface membrane associated protein inhibitor of DNA synthesis not expressed in young cells. Senescent cell membranes were used as immunogen to generate three monoclonal antibodies reacting specifically with senescent but not young cells in several normal human cell lines. We have also found that fibronectin messenger RNA accumulates to high levels in senescent cells. The role of these changes in gene expression in senescence is being explored.Key words: cellular senescence, human cells.

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