Harmonic motion imaging: a new technique for the detection of the local mechanical properties of tissues

2003 ◽  
Author(s):  
Elisa E. Konofagou ◽  
Kullervo H. Hynynen
Keyword(s):  
Mechanical Properties ◽  
New Technique ◽  
Harmonic Motion ◽  
A New Technique ◽  
Harmonic Motion Imaging ◽  
Motion Imaging

scholarly journals Harmonic motion imaging of human breast masses: an in vivo clinical feasibility

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Niloufar Saharkhiz ◽  
Richard Ha ◽  
Bret Taback ◽  
Xiaoyue Judy Li ◽  
Rachel Weber ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Malignant Tumors ◽  
Ex Vivo ◽  
Benign Tumors ◽  
Cancerous Tissue ◽  
Breast Masses ◽  
Harmonic Motion ◽  
Harmonic Motion Imaging ◽  
Motion Imaging

Abstract Non-invasive diagnosis of breast cancer is still challenging due to the low specificity of the imaging modalities that calls for unnecessary biopsies. The diagnostic accuracy can be improved by assessing the breast tissue mechanical properties associated with pathological changes. Harmonic motion imaging (HMI) is an elasticity imaging technique that uses acoustic radiation force to evaluate the localized mechanical properties of the underlying tissue. Herein, we studied the in vivo feasibility of a clinical HMI system to differentiate breast tumors based on their relative HMI displacements, in human subjects. We performed HMI scans in 10 female subjects with breast masses: five benign and five malignant masses. Results revealed that both benign and malignant masses were stiffer than the surrounding tissues. However, malignant tumors underwent lower mean HMI displacement (1.1 ± 0.5 µm) compared to benign tumors (3.6 ± 1.5 µm) and the adjacent non-cancerous tissue (6.4 ± 2.5 µm), which allowed to differentiate between tumor types. Additionally, the excised breast specimens of the same patients (n = 5) were imaged post-surgically, where there was an excellent agreement between the in vivo and ex vivo findings, confirmed with histology. Higher displacement contrast between cancerous and non-cancerous tissue was found ex vivo, potentially due to the lower nonlinearity in the elastic properties of ex vivo tissue. This preliminary study lays the foundation for the potential complementary application of HMI in clinical practice in conjunction with the B-mode to classify suspicious breast masses.

Mechanical deflection of cantilever microbeams: A new technique for testing the mechanical properties of thin films

1988 ◽  
Vol 3 (5) ◽  
pp. 931-942 ◽  
Author(s):  
T. P. Weihs ◽  
S. Hong ◽  
J. C. Bravman ◽  
W. D. Nix
Keyword(s):  
Thin Film ◽  
Thin Films ◽  
Mechanical Properties ◽  
Single Layer ◽  
Beam Theory ◽  
New Technique ◽  
Young’S Moduli ◽  
Silicon Micromachining ◽  
A New Technique

The mechanical deflection of cantilever microbeams is presented as a new technique for testing the mechanical properties of thin films. Single-layer microbeams of Au and SiO2 have been fabricated using conventional silicon micromachining techniques. Typical thickness, width, and length dimensions of the beams are 1.0,20, and 30 μm, respectively. The beams are mechanically deflected by a Nanoindenter, a submicron indentation instrument that continuously monitors load and deflection. Using simple beam theory and the load-deflection data, the Young's moduli and the yield strengths of thin-film materials that comprise the beams are determined. The measured mechanical properties are compared to those obtained by indenting similar thin films supported by their substrate.

A mechanical model to compute elastic modulus of tissues for harmonic motion imaging

2008 ◽  
Vol 41 (10) ◽  
pp. 2150-2158 ◽  
Author(s):  
Baoxiang Shan ◽  
Assimina A. Pelegri ◽  
Caroline Maleke ◽  
Elisa E. Konofagou
Keyword(s):  
Elastic Modulus ◽  
Mechanical Model ◽  
Harmonic Motion ◽  
Harmonic Motion Imaging ◽  
Motion Imaging

scholarly journals Non-contact, ultrasound-based indentation method for measuring elastic properties of biological tissues using Harmonic Motion Imaging (HMI)

2015 ◽  
Vol 60 (7) ◽  
pp. 2853-2868 ◽  
Author(s):  
Jonathan Vappou ◽  
Gary Y Hou ◽  
Fabrice Marquet ◽  
Danial Shahmirzadi ◽  
Julien Grondin ◽  
...  
Keyword(s):  
Elastic Properties ◽  
Biological Tissues ◽  
Indentation Method ◽  
Harmonic Motion ◽  
Harmonic Motion Imaging ◽  
Motion Imaging

A new technique for measuring the mechanical properties of thin films

1997 ◽  
Vol 6 (3) ◽  
pp. 193-199 ◽  
Author(s):  
W.N. Sharpe ◽  
B. Yuan ◽  
R.L. Edwards
Keyword(s):  
Thin Films ◽  
Mechanical Properties ◽  
New Technique ◽  
A New Technique
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