Multimodality vascular imaging phantom for calibration purpose

Since its first introduction in clinical practice in 2008, the concept of mobile stroke unit enabling prehospital stroke treatment has rapidly expanded worldwide. This review summarises current knowledge in this young field of stroke research, discussing topics such as benefits in reduction of delay before treatment, vascular imaging-based triage of patients with large-vessel occlusion in the field, differential blood pressure management or prehospital antagonisation of anticoagulants. However, before mobile stroke units can become routine, several questions remain to be answered. Current research, therefore, focuses on safety, long-term medical benefit, best setting and cost-efficiency as crucial determinants for the sustainability of this novel strategy of acute stroke management.

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Cross-Modality Imaging of Murine Tumor Vasculature—a Feasibility Study

Molecular Imaging and Biology ◽

10.1007/s11307-021-01615-y ◽

2021 ◽

Author(s):

Lydia M. Zopf ◽

Patrick Heimel ◽

Stefan H. Geyer ◽

Anoop Kavirayani ◽

Susanne Reier ◽

...

Keyword(s):

Cancer Biology ◽

Tumor Vasculature ◽

Vascular Imaging ◽

Melanoma Cancer ◽

Positron Emission ◽

Vessel Network ◽

Research Questions ◽

Magnetic Resonance Imaging Mri ◽

Single Tumor ◽

Penetration Depths

AbstractTumor vasculature and angiogenesis play a crucial role in tumor progression. Their visualization is therefore of utmost importance to the community. In this proof-of-principle study, we have established a novel cross-modality imaging (CMI) pipeline to characterize exactly the same murine tumors across scales and penetration depths, using orthotopic models of melanoma cancer. This allowed the acquisition of a comprehensive set of vascular parameters for a single tumor. The workflow visualizes capillaries at different length scales, puts them into the context of the overall tumor vessel network and allows quantification and comparison of vessel densities and morphologies by different modalities. The workflow adds information about hypoxia and blood flow rates. The CMI approach includes well-established technologies such as magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), and ultrasound (US), and modalities that are recent entrants into preclinical discovery such as optical coherence tomography (OCT) and high-resolution episcopic microscopy (HREM). This novel CMI platform establishes the feasibility of combining these technologies using an extensive image processing pipeline. Despite the challenges pertaining to the integration of microscopic and macroscopic data across spatial resolutions, we also established an open-source pipeline for the semi-automated co-registration of the diverse multiscale datasets, which enables truly correlative vascular imaging. Although focused on tumor vasculature, our CMI platform can be used to tackle a multitude of research questions in cancer biology.

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Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography

10.1117/12.2254724 ◽

2017 ◽

Author(s):

En Li ◽

Shuichi Makita ◽

Young-Joo Hong ◽

Deepa Kasaragod ◽

Yoshiaki Yasuno

Keyword(s):

Optical Coherence Tomography ◽

Human Skin ◽

Vascular Imaging ◽

Jones Matrix ◽

Optical Coherence

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Innovations in Vascular Imaging: Arteriography, Three-Dimensional CT Scans, and Two- and Three-Dimensional Intravascular Ultrasound Evaluation of an Abdominal Aortic Aneurysm

Annals of Vascular Surgery ◽

10.1007/bf02018177 ◽

1994 ◽

Vol 8 (3) ◽

pp. 285-289 ◽

Cited By ~ 28

Author(s):

Rodney A. White ◽

Marco Scoccianti ◽

Martin Back ◽

George Kopchok ◽

Carlos Donayre

Keyword(s):

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Intravascular Ultrasound ◽

Three Dimensional ◽

Vascular Imaging ◽

Ct Scans ◽

Ultrasound Evaluation ◽

Abdominal Aortic

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Micro-angiography for neuro-vascular imaging. I. Experimental evaluation and feasibility

Medical Physics ◽

10.1118/1.1617549 ◽

2003 ◽

Vol 30 (11) ◽

pp. 3018-3028 ◽

Cited By ~ 16

Author(s):

Arundhuti Ganguly ◽

Stephen Rudin ◽

Daniel R. Bednarek ◽

Kenneth R. Hoffmann ◽

Iacovos S. Kyprianou

Keyword(s):

Experimental Evaluation ◽

Vascular Imaging

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