Determination of the peak absorption wavelength and disaggregation kinetics of TOOKAD in vivo using dynamic, spatially resolved diffuse reflectance spectroscopy in a rabbit model

2002 ◽  
Author(s):  
Robert A. Weersink ◽  
Brian C. Wilson ◽  
Michael S. Patterson
Keyword(s):  
Diffuse Reflectance ◽  
Diffuse Reflectance Spectroscopy ◽  
Rabbit Model ◽  
Reflectance Spectroscopy ◽  
Spatially Resolved ◽  
Peak Absorption ◽  
Kinetics Of

scholarly journals Identifying clot composition using intravascular diffuse reflectance spectroscopy in a porcine model of endovascular thrombectomy

2021 ◽  
pp. neurintsurg-2020-017273
Author(s):  
Simon Skyrman ◽  
Gustav Burström ◽  
Oskar Aspegren ◽  
Gerald Lucassen ◽  
Adrian Elmi-Terander ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Vessel Wall ◽  
Diffuse Reflectance ◽  
Diffuse Reflectance Spectroscopy ◽  
Intravenous Thrombolysis ◽  
Reflectance Spectroscopy ◽  
Reliable Determination ◽  
Endovascular Thrombectomy

BackgroundEndovascular thrombectomy has revolutionized the management of acute ischemic stroke and proven superior to stand-alone intravenous thrombolysis for large vessel occlusions. However, failed or delayed revascularization may occur as a result of a mismatch between removal technique and clot composition. Determination of clot composition before thrombectomy provides the possibility to adapt the technique to improve clot removal efficacy. We evaluated the application of diffuse reflectance spectroscopy (DRS) for intravascular determination of clot composition in vivo.MethodsThree clot types, enriched in red blood cells or fibrin or with a mixed content, were prepared from porcine blood and injected into the external carotids of a domestic pig. A guidewire-like DRS probe was used to investigate the optical spectra of clots, blood and vessel wall. Measurement positions were confirmed with angiography. Spectra were analyzed by fitting an optical model to derive physiological parameters. To evaluate the method’s accuracy, photon scattering and blood and methemoglobin contents were included in a decision tree model and a random forest classification.ResultsDRS could differentiate between the three different clot types, blood and vessel wall in vivo (p<0.0001). The sensitivity and specificity for detection was 73.8% and 98.8% for red blood cell clots, 80.6% and 97.8% for fibrin clots, and 100% and 100% for mixed clots, respectively.ConclusionIntravascular DRS applied via a custom guidewire can be used for reliable determination of clot composition in vivo. This novel approach has the potential to increase efficacy of thrombectomy procedures in ischemic stroke.

Diffuse reflectance spectroscopy to quantify inflammation of the oral epithelium In Vivo

2002 ◽  
Author(s):  
David W. Hattery ◽  
Kristin Gerdelman ◽  
Farid Hekmat ◽  
Victor V. Chernomordik ◽  
Paul D. Smith ◽  
...  
Keyword(s):  
Diffuse Reflectance ◽  
Diffuse Reflectance Spectroscopy ◽  
Reflectance Spectroscopy ◽  
Oral Epithelium

scholarly journals In vivo nerve identification in head and neck surgery using diffuse reflectance spectroscopy

2018 ◽  
Vol 3 (5) ◽  
pp. 349-355 ◽  
Author(s):  
Gerrit C. Langhout ◽  
Koert F.D. Kuhlmann ◽  
Pim Schreuder ◽  
Torre Bydlon ◽  
Ludi E. Smeele ◽  
...  
Keyword(s):  
Head And Neck ◽  
Diffuse Reflectance ◽  
Diffuse Reflectance Spectroscopy ◽  
Neck Surgery ◽  
Reflectance Spectroscopy ◽  
Head And Neck Surgery ◽  
Nerve Identification

scholarly journals In vivo Estimation of Optical Coefficients of Rat Brain based on Diffuse Reflectance Spectroscopy

2016 ◽  
Vol 44 (4) ◽  
pp. 225
Author(s):  
Izumi Nishidate ◽  
Keiichiro Yoshida ◽  
Satoko Kawauchi ◽  
Shunichi Sato ◽  
Manabu Sato
Keyword(s):  
Rat Brain ◽  
Diffuse Reflectance ◽  
Diffuse Reflectance Spectroscopy ◽  
Reflectance Spectroscopy
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