Photodynamic therapy of malignant brain tumors: supplementary postoperative light delivery by implanted optical fibers: field fractionation

1991 ◽  
Author(s):  
Paul J. Muller ◽  
Brian C. Wilson
Keyword(s):  
Photodynamic Therapy ◽  
Brain Tumors ◽  
Optical Fibers ◽  
Light Delivery ◽  
Malignant Brain Tumors

Experimental and clinical results of mTHPC (Foscan)-mediated photodynamic therapy for malignant brain tumors

1998 ◽  
Author(s):  
Herwig Kostron ◽  
Alois Obwegeser ◽  
Rosanna Jakober ◽  
Andreas Zimmermann ◽  
Angelika C. Rueck
Keyword(s):  
Photodynamic Therapy ◽  
Brain Tumors ◽  
Clinical Results ◽  
Malignant Brain Tumors

Efficacy of the adjuvant intraoperative photodynamic therapy with Photolon® in patients with malignant brain tumors

2011 ◽  
Vol 8 (2) ◽  
pp. 164-165
Author(s):  
A.S. Fedulov ◽  
S.V. Shliakhtsin ◽  
T.V. Trukhachova ◽  
D.P. Veevnik ◽  
A.A. Borovsky ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Brain Tumors ◽  
Malignant Brain Tumors

scholarly journals Photodynamic therapy (PDT) for malignant brain tumors – Where do we stand?

2015 ◽  
Vol 12 (3) ◽  
pp. 530-544 ◽  
Author(s):  
Brendan J. Quirk ◽  
Garth Brandal ◽  
Steven Donlon ◽  
Juan Carlos Vera ◽  
Thomas S. Mang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Brain Tumors ◽  
Malignant Brain Tumors

scholarly journals Interstitial Photodynamic Therapy for Glioblastomas: A Standardized Procedure for Clinical Use

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5754
Author(s):  
Henri-Arthur Leroy ◽  
Gregory Baert ◽  
Laura Guerin ◽  
Nadira Delhem ◽  
Serge Mordon ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Optical Fibers ◽  
Intraoperative Imaging ◽  
Planning System ◽  
Treatment Planning System ◽  
Anatomical Location ◽  
Invasive Treatment ◽  
Interstitial Photodynamic Therapy

Glioblastomas (GBMs) are high-grade malignancies with a poor prognosis. The current standard of care for GBM is maximal surgical resection followed by radiotherapy and chemotherapy. Despite all these treatments, the overall survival is still limited, with a median of 15 months. For patients harboring inoperable GBM, due to the anatomical location of the tumor or poor general condition of the patient, the life expectancy is even worse. The challenge of managing GBM is therefore to improve the local control especially for non-surgical patients. Interstitial photodynamic therapy (iPDT) is a minimally invasive treatment relying on the interaction of light, a photosensitizer and oxygen. In the case of brain tumors, iPDT consists of introducing one or several optical fibers in the tumor area, without large craniotomy, to illuminate the photosensitized tumor cells. It induces necrosis and/or apoptosis of the tumor cells, and it can destruct the tumor vasculature and produces an acute inflammatory response that attracts leukocytes. Interstitial PDT has already been applied in the treatment of brain tumors with very promising results. However, no standardized procedure has emerged from previous studies. Herein, we propose a standardized and reproducible workflow for the clinical application of iPDT to GBM. This workflow, which involves intraoperative imaging, a dedicated treatment planning system (TPS) and robotic assistance for the implantation of stereotactic optical fibers, represents a key step in the deployment of iPDT for the treatment of GBM. This end-to-end procedure has been validated on a phantom in real operating room conditions. The thorough description of a fully integrated iPDT workflow is an essential step forward to a clinical trial to evaluate iPDT in the treatment of GBM.

scholarly journals Basics of Photodynamic Therapy for Malignant Brain Tumors

2016 ◽  
Vol 25 (11) ◽  
pp. 905-911
Author(s):  
Tetsuya Yamamoto ◽  
Hidehiro Kozuki ◽  
Takao Tsurubuchi ◽  
Masahide Matsuda ◽  
Hiroyoshi Akutsu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Brain Tumors ◽  
Malignant Brain Tumors

Repetitive Photodynamic Therapy of Malignant Brain Tumors

2006 ◽  
Vol 25 (1-2) ◽  
pp. 261-280 ◽  
Author(s):  
Henry Hirschberg ◽  
Dag R. Sorensen ◽  
Even Angell-Petersen ◽  
Qian Peng ◽  
Bruce Tromberg ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Brain Tumors ◽  
Malignant Brain Tumors
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