Deleterious effects of sunscreen titanium dioxide nanoparticles on DNA: efforts to limit DNA damage by particle surface modification

2001 ◽  
Author(s):  
Nick Serpone ◽  
Angela Salinaro ◽  
A. Emeline
Keyword(s):  
Dna Damage ◽  
Titanium Dioxide ◽  
Surface Modification ◽  
Titanium Dioxide Nanoparticles ◽  
Particle Surface

scholarly journals Comparison of Oxidative Stresses Mediated by Different Crystalline Forms and Surface Modification of Titanium Dioxide Nanoparticles

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Karim Samy El-Said ◽  
Ehab Mostafa Ali ◽  
Koki Kanehira ◽  
Akiyoshi Taniguchi
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Titanium Dioxide ◽  
Surface Modification ◽  
Titanium Dioxide Nanoparticles ◽  
Crystalline Form ◽  
Cellular Mechanisms ◽  
Oxidative Stresses ◽  
Wide Range ◽  
Crystalline Forms

Titanium dioxide nanoparticles (TiO2NPs) are manufactured worldwide for use in a wide range of applications. There are two common crystalline forms of TiO2anatase and rutile with different physical and chemical characteristics. We previously demonstrated that an increased DNA damage response is mediated by anatase crystalline form compared to rutile. In the present study, we conjugated TiO2NPs with polyethylene glycol (PEG) in order to reduce the genotoxicity and we evaluated some oxidative stress parameters to obtain information on the cellular mechanisms of DNA damage that operate in response to TiO2NPs different crystalline forms exposure in hepatocarcinoma cell lines (HepG2). Our results indicated a significant increase in oxidative stress mediated by the anatase form of TiO2NPs compared to rutile form. On the other hand, PEG modified TiO2NPs showed a significant decrease in oxidative stress as compared to TiO2NPs. These data suggested that the genotoxic potential of TiO2NPs varies with crystalline form and surface modification.

Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells

2012 ◽  
Vol 26 (2) ◽  
pp. 351-361 ◽  
Author(s):  
Quaiser Saquib ◽  
Abdulaziz A. Al-Khedhairy ◽  
Maqsood A. Siddiqui ◽  
Faisal M. Abou-Tarboush ◽  
Ameer Azam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Human Amnion

scholarly journals SURFACE MODIFICATION OF TITANIUM DIOXIDE NANOPARTICLES WITH ACRYLIC ACID/ISOBUTYLENE COPOLYMER UNDER ULTRASONIC TREATMENT

2019 ◽  
Vol 16 (32) ◽  
pp. 338-344
Author(s):  
Nikolay A. BULYCHEV ◽  
Lev N. RABINSKIY
Keyword(s):  
Titanium Dioxide ◽  
Surface Modification ◽  
Composite Materials ◽  
Acrylic Acid ◽  
Ultrasonic Treatment ◽  
Titanium Dioxide Nanoparticles ◽  
Polymer Coatings ◽  
Pigment Surface ◽  
Electrokinetic Sonic Amplitude ◽  
Modification Of Titanium

The influence of the ultrasonic treatment of block copolymer solution on its solid-liquid interface behavior was investigated in detail. The surface modification of titanium dioxide nanoparticles in aqueous dispersions of specially tailor-made periodic acrylic acid/isobutylene copolymer by ultrasonic treatment was studied in order to get new approaches for the creation of hybrid composite materials or polymer coatings. The pigment surface modification by the above copolymer was comparatively investigated regarding conventional adsorption as contrasted to an ultrasonic treatment assisted procedure. The course and efficiency of the polymer adsorption onto the pigment surface were quantified by electrokinetic sonic amplitude measurements. The higher efficiency of the pigment surface coating by the copolymer as achieved by ultrasonic treatment in comparison to conventional adsorption is a consequence of ultrasonically induced pigment surface activation. Two perspective avenues of the utilization of the discovered effects for creation of organic-inorganic composite materials are anticipated: the nanoparticles could first be treated by ultrasound in the presence of polymers and so create a surface modifying coating and the second option is an entrainment of the nanoparticles into the monomer matrix which can be polymerized afterward yielding a polymer with immobilized nanoparticles.

scholarly journals Titanium Dioxide Nanoparticles Induce DNA Damage and Genetic Instability In vivo in Mice

2009 ◽  
Vol 69 (22) ◽  
pp. 8784-8789 ◽  
Author(s):  
B. Trouiller ◽  
R. Reliene ◽  
A. Westbrook ◽  
P. Solaimani ◽  
R. H. Schiestl
Keyword(s):  
Dna Damage ◽  
Titanium Dioxide ◽  
Genetic Instability ◽  
Titanium Dioxide Nanoparticles

Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo

2015 ◽  
Vol 298 ◽  
pp. 310-319 ◽  
Author(s):  
Zhiqin Shi ◽  
Yujie Niu ◽  
Qian Wang ◽  
Lei Shi ◽  
Huicai Guo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles
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