Minimally invasive ultrasound thermal therapy with MR thermal monitoring and guidance

Author(s):  
Chris J. Diederich ◽  
R. Jason Stafford ◽  
Roger E. Price ◽  
William H. Nau ◽  
Per Daniel Tyreus ◽  
...  
2018 ◽  
Vol 45 (3) ◽  
pp. E9 ◽  
Author(s):  
Zulma Tovar-Spinoza ◽  
Robert Ziechmann ◽  
Stephanie Zyck

OBJECTIVEMagnetic resonance–guided laser interstitial thermal therapy (MRgLITT) is a novel, minimally invasive treatment for the surgical treatment of epilepsy. In this paper, the authors report on clinical outcomes for a series of pediatric patients with tuberous sclerosis complex (TSC) and medication-refractory epileptogenic cortical tubers.METHODSA retrospective chart review was performed at SUNY Upstate Golisano Children’s Hospital in Syracuse, New York. The authors included all cases involving pediatric patients (< 18 years) who underwent MRgLITT for ablation of epileptogenic cortical tubers between February 2013 and November 2015.RESULTSSeven patients with cortical tubers were treated (4 female and 3 male). The patients’ average age was 6.6 years (range 2–17 years). Two patients had a single procedure, and 5 patients had staged procedures. The mean time between procedures in the staged cases was 6 months. All of the patients had a meaningful reduction in seizure frequency as reported by Engel and ILAE seizure outcome classifications, and most (71.4%) of the patients experienced a reduction in AED burden. Three of the 4 patients who presented with neuropsychiatric symptoms had some improvement in these domains after laser ablation. No perioperative complications were noted. The mean duration of follow-up was 19.3 months (range 4–49 months).CONCLUSIONSLaser ablation represents a minimally invasive alternative to resective epilepsy surgery and is an effective treatment for refractory epilepsy due to cortical tubers.


Biomaterials ◽  
2015 ◽  
Vol 44 ◽  
pp. 91-102 ◽  
Author(s):  
Haitang Shi ◽  
Tianlong Liu ◽  
Changhui Fu ◽  
Linlin Li ◽  
Longfei Tan ◽  
...  

1999 ◽  
Author(s):  
Koichi Ito ◽  
Hiroyuki Yoshimura ◽  
Kazuyuki Saito ◽  
Lira Hamada

2007 ◽  
Author(s):  
Chris J. Diederich ◽  
Will H. Nau ◽  
Adam Kinsey ◽  
Tony Ross ◽  
Jeff Wootton ◽  
...  

1999 ◽  
Author(s):  
Chris J. Diederich ◽  
William H. Nau ◽  
Dana L. Deardorff ◽  
Sharmila Majumdar ◽  
Srinka Ghosh ◽  
...  

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