Photodynamic effect produced by HeNe radiation in Harderian glands of Wistar rats: an experimental model for PDT studies

2000 ◽  
Author(s):  
Edmyr R. dos Reis ◽  
Ester M. D. Nicola ◽  
Konradin Metze ◽  
Jorge H. Nicola
Keyword(s):  
Experimental Model ◽  
Wistar Rats ◽  
Photodynamic Effect ◽  
Harderian Glands

scholarly journals Hormones of thyroid gland in sera of rats treated with different dose of concentrated potassium iodine solutions

2010 ◽  
Vol 138 (5-6) ◽  
pp. 323-327 ◽  
Author(s):  
Ljiljana Markovic ◽  
Violeta Mihailovic-Vucinic ◽  
Jelena Aritonovic
Keyword(s):  
Thyroid Gland ◽  
Genetic Susceptibility ◽  
Experimental Model ◽  
Wistar Rats ◽  
Morphological Changes ◽  
Cell Necrosis ◽  
High Iodine ◽  
Hormone Status ◽  
Potassium Iodine ◽  
Iodine Dose

Introduction Potassium iodine (KI) is used as a drug therapy for treating numerous diseases such as small-vessel vasculitis, erythema nodosum, vasculitis nodularis, Sweet's syndrome, tuberculosis and granulomatosis, and for iodized salt. At the same time, KI can be harmful. Iodine intake may increase the frequency of thyroiditis in humans, and may induce the occurrence of experimental thyroiditis (ET) in animals. Investigations on an experimental model for the examination of thyroiditis in Wistar rats have clearly showed morphological changes in the rat thyroid evoked by KI administration. Objective The purpose of this study was to compare the effects of low and high doses of KI on the thyroid gland of Wistar rats and determine the effect on hormone status (T4, T3 and TSH) in this rat strain. Methods Two groups of rats from the Wistar strain were treated with a low iodine dose (225 ?g/g BW) and with a high iodine dose (675 ?g/g BW) of KI solutions. Untreated nonimmunized animals served as controls. The solution was administrated daily intraperitoneally during the period of 26 consecutive days. Results Monitoring hormone status (TSH, T3 and T4) and morphological changes it was found that therapeutic doses of KI applied in treatment induced the occurrence of experimental thyroiditis (chronic destructive Hashimoto's thyroiditis in humans) and cell necrosis in animals not carrying a genetic susceptibility. Significant inflammatory changes were observed in rats treated with a high iodine dose. Conclusion The early iodine induced cell necrosis and inflammation in the nonimmunized animals without genetic susceptibility is a new experimental model of thyroiditis. .

scholarly journals Urinary N-Acetyl-Beta-D-Glucosaminidase Activity in Rat Experimental Ischemic and Toxic Models of Acute Kidney Injury

2017 ◽  
Vol 74 (1) ◽  
pp. 105
Author(s):  
Razvan Andrei CODEA ◽  
Mircea MIRCEAN ◽  
Sidonia Alina BOGDAN ◽  
Andras Laszlo NAGY ◽  
Alexandra BIRIS ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Experimental Model ◽  
Wistar Rats ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Control Group ◽  
Tubular Injury ◽  
Group 2 ◽  
Group 1

The identification of a suitable prevention method which facilitates limiting the deleterious effects of acute kidney injuries is highly required. In order to identify a proper treatment for acute kidney injuries, a suitable experimental model that replicates the structural, metabolic and inflammatory lesions that occur in the natural acute injured kidney is highly necessary. Intense urinary NAG activity can be found in a variety of renal disease such as toxic nephropathies, ischemic renal injury following cardiac surgery or renal transplantation but also in glomerular disease especially in diabetic nephropathy. Rises in urinary NAG enzyme activity strongly suggests tubular cell damage and support NAG enzyme as a biomarker of renal tubular injury. The aim of this paper is to obtain a stable in vivo acute kidney injury experimental model, in Wistar, rats and to evaluate the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) enzyme, blood levels of urea and creatinine and microstructural renal alterations induced by ischemia/reperfusion injury respectively gentamicin nephrotoxicity. For this purpose we have used a rat experimental model. Adult male Wistar rats weighing 250-300 g were randomly divided into 3 groups with 8 rats in each group. Group 1 served as a model for the renal ischemia/reperfusion injury experiment, group 2 served for toxic kidney injury experimental model and group 3 served as control group. All individuals in both groups 1 and 2 presented marked elevations in blood urea and creatinine at the moment of euthanasia (day 3 for group 1 and day 9 for group 2) compared to the control group where biochemical values remained within normal limits. Urine analysis of both group 1 and 2 showed marked urinary NAG index activity which suggests acute tubular injury, suggestion confirmed by histological evaluation of the renal parenchyma sampled from this subjects

Analysis of the Morphological Signs of an Inflammatory Reaction in the Spinal Cord of Wistar Rats in an Experimental Model

2011 ◽  
Vol 42 (1) ◽  
pp. 43-47 ◽  
Author(s):  
E. G. Gilerovich ◽  
E. A. Fedorova ◽  
I. N. Abdurasulova ◽  
M. N. Karpenko ◽  
A. V. Sokolov ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Experimental Model ◽  
Inflammatory Reaction ◽  
Wistar Rats

Experimental Evaluation of Osteoinduction of Recombinant Bone Morphogenic Protein (rhBMP-2) of Native Production Fixative on Biocomposite or Bone Matrix

2010 ◽  
Vol 17 (4) ◽  
pp. 38-44
Author(s):  
S P Mironov ◽  
A L Gintsburg ◽  
N A Es'kin ◽  
V G Lunin ◽  
N S Gavryushenko ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Experimental Model ◽  
Experimental Evaluation ◽  
Wistar Rats ◽  
Bone Matrix ◽  
Bone Morphogenic Protein ◽  
Autopsy Material ◽  
Roentgenologic Examination ◽  
Material Evaluation ◽  
Biocomposite Material

Data on experimental evaluation of osteoinduction of recombinant bone morphogenic protein of native production fixative on xenogenic demineralizated bone matrix or collagen-calcium-phosphate biocomposite material. Evaluation was performed using experimental model of end-to-end osteosynthesis of diaphyseal femur fragments by external fixative device in Wistar rats. Roentgenologic examination, study of autopsy material and evaluation of bone consolidation strength using biomechanical twisting test showed high osteoinduction of rhBMP-2 containing biocomposites.

Monoolein and chitosan gels as potential carriers of the rhBMP-2, using decortication surgical technique in Wistar rats as experimental model

Micron ◽  
2008 ◽  
Vol 39 (7) ◽  
pp. 952-959 ◽  
Author(s):  
João Paulo Mardegan Issa ◽  
Augusto César Cropanese Spadaro ◽  
Maria Vitória L.B. Bentley ◽  
Mamie Mizusaki Iyomasa ◽  
Selma Siéssere ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Experimental Model ◽  
Wistar Rats

Photodynamic activity of protoporphyrin IX in Harderian glands of Wistar rats: Monitoring by gland fluorescence

2013 ◽  
Vol 137 ◽  
pp. 32-36 ◽  
Author(s):  
E.R. Reis ◽  
K. Metze ◽  
E.M.D. Nicola ◽  
J.H. Nicola ◽  
I.E. Borissevitch
Keyword(s):  
Wistar Rats ◽  
Protoporphyrin Ix ◽  
Harderian Glands ◽  
Photodynamic Activity

scholarly journals Mandibular Branch of the Facial Nerve in Wistar Rats: New Experimental Model to Assess Facial Nerve Regeneration

2014 ◽  
Vol 18 (03) ◽  
pp. 277-282 ◽  
Author(s):  
Ricardo Bento ◽  
Raquel Salomone ◽  
Ricardo Ferreira ◽  
Ciro Silva ◽  
Heloisa Costa ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Nerve Regeneration ◽  
Experimental Model ◽  
Wistar Rats ◽  
Mandibular Branch

scholarly journals Prophylactic use of botulinum toxin applied to the abdominal wall to optimize the primary closure of the open abdomen in Wistar rats. Experimental model.

2019 ◽  
Author(s):  
Gerardo Sánchez Miranda ◽  
Efrén Flores Álvarez ◽  
Ramiro Gómez Arambulo ◽  
Miguel Magdaleno García ◽  
Alejandro Palafox Hernández ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Abdominal Wall ◽  
Experimental Model ◽  
Wistar Rats ◽  
Primary Closure ◽  
Open Abdomen ◽  
Prophylactic Use

scholarly journals Transverse rectus abdominis musculocutaneous flap (TRAM flap) - experimental model in rats

2003 ◽  
Vol 18 (spe) ◽  
pp. 46-53 ◽  
Author(s):  
Pedro Bins Ely ◽  
Lydia Masako Ferreira
Keyword(s):  
Experimental Model ◽  
Wistar Rats ◽  
Rectus Abdominis ◽  
Musculocutaneous Flap ◽  
Tram Flap ◽  
Flap Procedure ◽  
Male Wistar Rats

The objective of this paper was to report the use of an experimental model of the Transverse Rectus Abdominis Musculocutaneous flap (TRAM flap), in rats. Thirty male Wistar rats weighing 180 to 220 g were submitted to the TRAM flap procedure. This article reports on the use of the caudally based, right unipedicled TRAM flap.

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