Correlation between solution and gas-phase protein conformation: H/D exchange, IRMPD, and ESI FT-ICR MS

2000 ◽  
Author(s):  
Michael A. Freitas ◽  
Christopher L. Hendrickson ◽  
Alan G. Marshall
Keyword(s):  
Gas Phase ◽  
Protein Conformation ◽  
Phase Protein ◽  
Ft Icr Ms ◽  
Ft Icr

Dehydrogenation of Ethane by CpM+(M = Fe, Co, Ni) in the Gas Phase. An FT-ICR-MS Study

1999 ◽  
Vol 18 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Dag Ekeberg ◽  
Einar Uggerud ◽  
Hung-Yu Lin ◽  
Karl Sohlberg ◽  
Henglong Chen ◽  
...  
Keyword(s):  
Gas Phase ◽  
Ft Icr Ms ◽  
Ft Icr

Gas-Phase Actinide Ion Chemistry:  FT-ICR/MS Study of the Reactions of Thorium and Uranium Metal and Oxide Ions with Arenes

1997 ◽  
Vol 16 (21) ◽  
pp. 4581-4588 ◽  
Author(s):  
Joaquim Marçalo ◽  
João Paulo Leal ◽  
António Pires de Matos ◽  
Alan G. Marshall
Keyword(s):  
Gas Phase ◽  
Ion Chemistry ◽  
Uranium Metal ◽  
Oxide Ions ◽  
Ft Icr Ms ◽  
Ft Icr

Gas phase investigations of sulfonium salts by electrospray ft-icr/ms

1997 ◽  
Vol 165-166 ◽  
pp. 577-583 ◽  
Author(s):  
Alan R. Katritzky ◽  
Petia A. Shipkova ◽  
Clifford H. Watson ◽  
John R. Eyler ◽  
Dennis N. Kevill
Keyword(s):  
Gas Phase ◽  
Sulfonium Salts ◽  
Ft Icr Ms ◽  
Ft Icr

Gas-Phase Ligand Exchange in a Square-Planar Rhodium(I) Complex Proceeding by Dissociative Exchange:  ESI FT-ICR MS and DFT Evidence

2004 ◽  
Vol 23 (1) ◽  
pp. 144-148 ◽  
Author(s):  
Robert E. Bossio ◽  
Norris W. Hoffman ◽  
Thomas R. Cundari ◽  
Alan G. Marshall
Keyword(s):  
Gas Phase ◽  
Ligand Exchange ◽  
Square Planar ◽  
Ft Icr Ms ◽  
Ft Icr

PHYTOCHEMICAL SCREENING, ANTIOXIDANT, ANTI-CYTOTOXIC AND ANTICANCER EFFECTS OF GALINSOGA PARVIFLORA AND VERNONIA POLYANTHES (ASTERACEAE) EXTRACTS

2020 ◽  
Vol 8 (10) ◽  
pp. 84-98
Author(s):  
Sula M. V. Feleti ◽  
Renê L. Aleluia ◽  
Suiany V. Gervásio ◽  
Jean Carlos V. Dutra ◽  
Jessica R. P. Oliveira ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Phenolic Acids ◽  
Unsaturated Fatty Acids ◽  
Biological Effects ◽  
Human Lymphocytes ◽  
Chemical Characterization ◽  
Total Content ◽  
Ags Cells ◽  
Ft Icr Ms ◽  
Ft Icr

The study was designed to investigate the chemical composition and the biological effects of G. parviflora and V. polyanthes ethanolic extracts in vitro. Total content of phenols, flavonoids and tannins was quantified by spectrophotometry; chemical characterization was permed by mass spectrometry (ESI (-) FT-ICR MS and APCI (+) FT-ICR MS analysis). Antioxidant activities were determined by FRAP and Fe2+ chelating methods. Extracts cytotoxicity was evaluated in human lymphocytes, sarcoma-180 (S-180) and human gastric adenocarcinoma (AGS) cells, by MTT assay. V. polyanthes presented higher total content of tannins and G. parviflora presented higher amount of phenols and flavonoids. Chemical characterization showed the presence of flavonoids, phenolic acids and sesquiterpene lactones in V. polyanthes extract, and steroids, phenolic acids and fatty acids (Poly Unsaturated Fatty Acids - PUFA) in G. parviflora extract. V. polyanthes extract stood out in the Fe2+ chelation test. G. parviflora extract did not present outstanding antioxidant results in the tested protocols. Both species showed a tendency to promote cytotoxicity in human lymphocyte cells. Regarding the antiproliferative effect, both species were able to reduce S-180 cell viability and G. parviflora extract showed high antiproliferative potential in the assay with AGS cells. These findings reinforce the medicinal use of these plants, as well as suggest their potential use for the development of new drugs and for the treatment of cancers.

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