Comparison of in-vivo skin models for near-infrared laser exposure

1999 ◽  
Author(s):  
Thomas A. Eggleston ◽  
Michael A. Mitchell ◽  
Thomas E. Johnson ◽  
Robert L. Becker, Jr. ◽  
William P. Roach
Keyword(s):  
Near Infrared ◽  
Infrared Laser ◽  
Laser Exposure

Hemoglobin degradation in human erythrocytes with long-duration near-infrared laser exposure in Raman optical tweezers

2010 ◽  
Vol 15 (5) ◽  
pp. 055009 ◽  
Author(s):  
Raktim Dasgupta ◽  
Sunita Ahlawat ◽  
Ravi Shanker Verma ◽  
Abha Uppal ◽  
Pradeep Kumar Gupta
Keyword(s):  
Optical Tweezers ◽  
Near Infrared ◽  
Infrared Laser ◽  
Human Erythrocytes ◽  
Laser Exposure ◽  
Long Duration ◽  
Hemoglobin Degradation

scholarly journals Intravital Imaging Study on Photodamage Produced by Femtosecond Near-infrared Laser Pulses In Vivo

2016 ◽  
Vol 92 (2) ◽  
pp. 308-313 ◽  
Author(s):  
Sergey N. Arkhipov ◽  
Ilyas Saytashev ◽  
Marcos Dantus
Keyword(s):  
Near Infrared ◽  
Imaging Study ◽  
Laser Pulses ◽  
Infrared Laser ◽  
Intravital Imaging

PEGylated nickel carbide nanocrystals as efficient near-infrared laser induced photothermal therapy for treatment of cancer cells in vivo

Nanoscale ◽  
2014 ◽  
Vol 6 (21) ◽  
pp. 12591-12600 ◽  
Author(s):  
Zhiguo Zhou ◽  
Jun Wang ◽  
Wei Liu ◽  
Chao Yu ◽  
Bin Kong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Laser ◽  
Nickel Carbide

scholarly journals An internal cross-linked polymeric nanoparticle with dual sensitivity for combination therapy of muscle-invasive bladder cancer

2020 ◽  
Author(s):  
Guanchen Zhu ◽  
Kaikai Wang ◽  
Haixiang Qin ◽  
Xiaozhi Zhao ◽  
Wei Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation ◽  
Targeting Ability

Abstract Chemotherapy is a standard cancer treatment which uses anti-cancer drugs to destroy or slow the growth of cancer cells. However, chemotherapy has limited therapeutic effects in bladder cancer. One of the reasons of this resistance to chemotherapy is that higher levels of glutathione in invasive bladder cancer cells. We have fabricated nanoparticles that respond to high concentrations of glutathione and near-infrared laser irradiation in order to increase the drug accumulation at the tumor sites and combine chemotherapy with photothermal therapy to overcome the challenges of bladder cancer treatment.Methods:The DOX&IR780@PEG-PCL-SS NPs were prepared by co-precipitation method. We investigated the tumor targeting capability of NPs in vitro and in vivo. The orthotopic bladder cancer model in C57BL/6 mice was established for in vivo study and the photothermal effects and therapeutic efficacy of NPs were evaluated.Results:The DOX&IR780@PEG-PCL-SS NPs were synthesized using internal cross-linking strategy to increase the stability of nanoparticles. Nanoparticles can be ingested by tumor cells in a short time. The DOX&IR780@PEG-PCL-SS NPs have dual sensitivity to high levels of glutathione in bladder cancer cells and near-infrared laser irradiation. Glutathione triggers chemical structural changes of nanoparticles and preliminarily releases drugs, Near-infrared laser irradiation can promote the complete release of the drugs from the nanoparticles and induce a photothermal effect, leading to destroying the tumor cells. Given the excellent tumor-targeting ability and negligible toxicity to normal tissue, DOX&IR780@PEG-PCL-SS NPs can greatly increase the concentration of the anti-cancer drugs in tumor cells. The mice treated with DOX&IR780@PEG-PCL-SS NPs have a significant reduction in tumor volume. The DOX&IR780@PEG-PCL-SS NPs can be tracked by in vivo imaging system and have good tumor targeting ability, to facilitate our assessment during the experiment.Conclusion:A nanoparticle delivery system with dual sensitivity to glutathione and near-infrared laser irradiation was developed for delivering IR780 and DOX. Chemo-photothermal synergistic therapy of both primary bladder cancer and their metastases was achieved using this advanced delivery system.

Use of Indocyanine Green Near-Infrared Laser Confocal Endomicroscopy In Vivo: Potential to Intraoperatively Detect the Boundary of Infiltrative Tumor

Neurosurgery ◽  
2010 ◽  
Vol 67 (2) ◽  
pp. 562-562 ◽  
Author(s):  
Nikolay L. Martirosyan ◽  
Daniel Dutra Cavalcanti ◽  
Jennifer M. Eschbacher ◽  
Peter Delaney ◽  
Mohammed G. Abdelwahab ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Infrared Laser ◽  
Confocal Endomicroscopy ◽  
Infiltrative Tumor

Facile fabrication of a resveratrol loaded phospholipid@reduced graphene oxide nanoassembly for targeted and near-infrared laser-triggered chemo/photothermal synergistic therapy of cancer in vivo

2017 ◽  
Vol 5 (29) ◽  
pp. 5783-5792 ◽  
Author(s):  
Luo Hai ◽  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Xue Yang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Near Infrared ◽  
Infrared Laser ◽  
Reduced Graphene ◽  
Facile Fabrication

A resveratrol-loaded phospholipid coated reduced graphene oxide was prepared using a sonication method.

scholarly journals Comparative Study of the Optical and Heat Generation Properties of IR820 and Indocyanine Green

2012 ◽  
Vol 11 (2) ◽  
pp. 7290.2011.00031 ◽  
Author(s):  
Alicia Fernandez-Fernandez ◽  
Romila Manchanda ◽  
Tingjun Lei ◽  
Denny A. Carvajal ◽  
Yuan Tang ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Experimental Models ◽  
Cyanine Dye ◽  
Laser Exposure ◽  
Fluorescence Signal ◽  
Thermal Generation ◽  
Significant Difference

Near-infrared (NIR) fluorophores are the focus of extensive research for combined molecular imaging and hyperthermia. In this study, we showed that the cyanine dye IR820 has optical and thermal generation properties similar to those of indocyanine green (ICG) but with improved in vitro and in vivo stability. The fluorescent emission of IR820 has a lower quantum yield than ICG but less dependence of the emission peak location on concentration. IR820 demonstrated degradation half-times approximately double those of ICG under all temperature and light conditions in aqueous solution. In hyperthermia applications, IR820 generated lower peak temperatures than ICG (4–9%) after 3-minute laser exposure. However, there was no significant difference in hyperthermia cytotoxicity, with both dyes causing significant cell growth inhibition at concentrations ≥ 5 μM. Fluorescent images of cells with 10 μM IR820 were similar to ICG images. In rats, IR820 resulted in a significantly more intense fluorescence signal and significantly higher organ dye content than for ICG 24 hours after intravenous dye administration ( p < .05). Our study shows that IR820 is a feasible agent in experimental models of imaging and hyperthermia and could be an alternative to ICG when greater stability, longer image collection times, or more predictable peak locations are desirable.

scholarly journals In vivo evaluation of the combination effect of near-infrared laser and 5-fluorouracil-loaded PLGA-coated magnetite nanographene oxide

2018 ◽  
Vol 46 (sup2) ◽  
pp. 25-33 ◽  
Author(s):  
Arezoo Mohammadi Gazestani ◽  
Samideh Khoei ◽  
Sepideh Khoee ◽  
Soraya Emamgholizadeh Minaei ◽  
Manijeh Motevalian
Keyword(s):  
Near Infrared ◽  
Infrared Laser ◽  
Combination Effect ◽  
In Vivo Evaluation
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