Handheld directional reflectometer: an angular imaging device to measure BRDF and HDR in real time

1998 ◽  
Author(s):  
Phillip R. Mattison ◽  
Mark S. Dombrowski ◽  
James M. Lorenz ◽  
Keith J. Davis ◽  
Harley C. Mann ◽  
...  
Keyword(s):  
Real Time ◽  
Imaging Device

scholarly journals Design, Development, and Multi-Characterization of an Integrated Clinical Transrectal Ultrasound and Photoacoustic Device for Human Prostate Imaging

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 566 ◽  
Author(s):  
Sumit Agrawal ◽  
Kerrick Johnstonbaugh ◽  
Joseph Y. Clark ◽  
Jay D. Raman ◽  
Xueding Wang ◽  
...  
Keyword(s):  
Real Time ◽  
Needle Biopsy ◽  
Imaging Modality ◽  
Experimental Studies ◽  
Transrectal Ultrasound ◽  
Human Prostate ◽  
Design Development ◽  
Imaging Device ◽  
Prostate Imaging ◽  
Clinically Significant

The standard diagnostic procedure for prostate cancer (PCa) is transrectal ultrasound (TRUS)-guided needle biopsy. However, due to the low sensitivity of TRUS to cancerous tissue in the prostate, small yet clinically significant tumors can be missed. Magnetic resonance imaging (MRI) with TRUS fusion biopsy has recently been introduced as a way to improve the identification of clinically significant PCa in men. However, the spatial errors in coregistering the preprocedural MRI with the real-time TRUS causes false negatives. A real-time and intraprocedural imaging modality that can sensitively detect PCa tumors and, more importantly, differentiate aggressive from nonaggressive tumors could largely improve the guidance of biopsy sampling to improve diagnostic accuracy and patient risk stratification. In this work, we seek to fill this long-standing gap in clinical diagnosis of PCa via the development of a dual-modality imaging device that integrates the emerging photoacoustic imaging (PAI) technique with the established TRUS for improved guidance of PCa needle biopsy. Unlike previously published studies on the integration of TRUS with PAI capabilities, this work introduces a novel approach for integrating a focused light delivery mechanism with a clinical-grade commercial TRUS probe, while assuring much-needed ease of operation in the transrectal space. We further present the clinical potential of our device by (i) performing rigorous characterization studies, (ii) examining the acoustic and optical safety parameters for human prostate imaging, and (iii) demonstrating the structural and functional imaging capabilities using deep-tissue-mimicking phantoms. Our TRUSPA experimental studies demonstrated a field-of-view in the range of 130 to 150 degrees and spatial resolutions in the range of 300 μm to 400 μm at a soft tissue imaging depth of 5 cm.

scholarly journals Verification of MLC based real-time tumor tracking using an electronic portal imaging device

2010 ◽  
Vol 37 (6Part1) ◽  
pp. 2435-2440 ◽  
Author(s):  
Sarah Han-Oh ◽  
Byong Yong Yi ◽  
Fritz Lerma ◽  
Barry L. Berman ◽  
Minzhi Gui ◽  
...  
Keyword(s):  
Real Time ◽  
Electronic Portal Imaging Device ◽  
Imaging Device ◽  
Portal Imaging ◽  
Electronic Portal Imaging ◽  
Tumor Tracking

A Real Time Cost Effective Geometry Calibration Method for Isocenter Tracking of a Rotating Gantry Using Optical Vision Sensors

2016 ◽  
Author(s):  
Zheng Yuan Li ◽  
Sungsoo Ryo ◽  
Hyuk Jin Lee ◽  
Ja Choon Koo
Keyword(s):  
Real Time ◽  
Cost Effective ◽  
Calibration Method ◽  
Image Sensors ◽  
Deformation Analysis ◽  
Relative Deformation ◽  
Imaging Device ◽  
Radiography System ◽  
Vision Sensors ◽  
Position Data

In this paper, a real time and cost effective deformation sensor system is proposed to verify isocenter sphere of a dual-head radiation imaging device within its driving range. For the effectiveness in sensing, installation point was decided according to the finite element deformation analysis of the device model. The proposed sensor was implemented to the device, and then the result was evaluated by comparison with an optical tracker position data. In this method, attachable optical system were designed and implemented to the dedicated radiography system. From the attachment test relative deformation data of two orthogonal X-Ray tube and detector sets were obtained simultaneously by two image sensors attached on each of them. Laser spot orbits were obtained as a result, and were compared with optical tracker data results for verification. The proposed method significantly reduces costs and time spent for calibration process while satisfying micro scale precision requirements and it is applicable to other rotation mechanical system. Comprising devices costs much less than the manufacturing or purchasing a dedicated geometry phantoms, because this method only requires a low powered spot laser and a CMOS Camera plus additional optical devices.

scholarly journals Efficacy of a bacterial fluorescence imaging device in an outpatient wound care clinic: a pilot study

2019 ◽  
Vol 28 (7) ◽  
pp. 438-443 ◽  
Author(s):  
Ciaran M. Hurley ◽  
Pat McClusky ◽  
Ryan M. Sugrue ◽  
James A. Clover ◽  
Jason E. Kelly
Keyword(s):  
Real Time ◽  
Fluorescence Imaging ◽  
Predictive Value ◽  
Pathogenic Bacteria ◽  
Wound Care ◽  
Bacterial Species ◽  
University Hospital ◽  
Fluorescent Light ◽  
Care Clinic ◽  
Imaging Device

Objective: Subsurface bacterial burden can be missed during standard wound examination protocols. The real-time bacterial fluorescence imaging device, MolecuLight i:X, visualises the presence of potentially harmful levels of bacteria through endogenous autofluorescence, without the need for contrast agents or contact with the patient. The intended use of the imaging device is to assist with the management of patients with wounds by enabling real-time visualisation of potentially harmful bacteria. The aim of this study was to establish the accuracy of the wound imaging device at detecting pathogenic bacteria in wounds. Methods: A single-centre, prospective observational study was conducted in Cork University Hospital in an outpatient plastic surgery wound care clinic. Patients had their wounds photographed under white and autofluorescent light with the imaging device. Auto-fluorescent images were compared with the microbiological swab results. Results: A total of 33 patients and 43 swabs were included, of which 95.3% (n=41) were positive for bacteria growth. Staphylococcus aureus was the most common bacterial species identified. The imaging device had a sensitivity of 100% and specificity of 78% at identifying pathological bacteria presence in wounds on fluorescent light imaging. The positive predictive value (PPV) was 95.4%. The negative predictive value (NPV) was 100%. It demonstrated a sensitivity and specificity of 100% at detecting the presence of Pseudomonas spp. Conclusion: The imaging device used could be a safe, effective, accurate and easy-to-use autofluorescent device to improve the assessment of wounds in the outpatient clinic setting. In conjunction with best clinical practice, the device can be used to guide clinicians use of antibiotics and specialised dressings.

scholarly journals Real-time Visualization of Breast Carcinoma in Pathology Specimens From Patients Receiving Fluorescent Tumor-Marking Agent Tozuleristide

2018 ◽  
Vol 143 (9) ◽  
pp. 1076-1083 ◽  
Author(s):  
Suzanne M. Dintzis ◽  
Stacey Hansen ◽  
Kristi M. Harrington ◽  
Lennart C. Tan ◽  
Dennis M. Miller ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Real Time ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Ex Vivo ◽  
Clinical Pathology ◽  
Low Grade ◽  
Imaging Device ◽  
Invasive Carcinomas

Context.— Resection of breast carcinoma with adequate margins reduces the risk of local recurrence and reoperation. Tozuleristide (BLZ-100) is an investigational peptide-fluorophore agent that may aid in intraoperative tumor detection and margin assessment. In this study, fluorescence imaging was conducted ex vivo on gross breast pathology specimens. Objectives.— To determine the potential of tozuleristide to detect breast carcinoma in fresh pathology specimens and the feasibility of fluorescence-guided intraoperative pathology assessment of surgical margins. Design.— Twenty-three patients received an intravenous bolus dose of 6 or 12 mg of tozuleristide at least 1 hour before surgery. Fifteen lumpectomy and 12 mastectomy specimens were evaluated for fluorescence by the site's clinical pathology staff using the SIRIS, an investigational near-infrared imaging device. The breast tissue was then processed per usual procedures. Fluorescent patterns were correlated with the corresponding hematoxylin-eosin–stained sections. Clinical pathology reports were used to correlate fluorescent signal to grade, histotype, prognostic marker status, and margin measurements. Results.— Tozuleristide fluorescence was readily observed in invasive and in situ breast carcinoma specimens. Most invasive carcinomas were bright and focal, whereas in situ lesions demonstrated a less intense, more diffuse pattern. Tozuleristide was detected in ductal and lobular carcinomas with a similar fluorescent pattern. Fluorescence was detected in high- and low-grade lesions, and molecular marker/hormone receptor status did not affect signal. Fluorescence could be used to identify the relationship of carcinoma to margins intraoperatively. Conclusions.— Tumor targeting with tozuleristide allowed visual real-time distinction between pathologically confirmed breast carcinoma and normal tissue.

Fluorescence imaging guided dressing change frequency during negative pressure wound therapy: a case series

2019 ◽  
Vol 28 (Sup9) ◽  
pp. S28-S37 ◽  
Author(s):  
Rose Raizman
Keyword(s):  
Real Time ◽  
Fluorescence Imaging ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Case Series ◽  
Cost Effective ◽  
Wound Therapy ◽  
Imaging Device ◽  
Treatment Regimens ◽  
Selection Of

Objective: Knowledge of wound bioburden can guide selection of therapies, for example, the use of negative pressure wound therapy (NPWT) devices with instillation in a heavily contaminated wound. Wound and periwound bacteria can be visualised in real-time using a novel, non-contact, handheld fluorescence imaging device that emits a safe violet light. This device was used to monitor bacterial burden in patients undergoing NPWT. Methods: Diverse wounds undergoing NPWT were imaged for bacterial (red or cyan) fluorescence as part of routine wound assessments. Results: We assessed 11 wounds undergoing NPWT. Bacterial fluorescence was detected under sealed, optically-transparent (routine) adhesive before dressing changes, on foam dressings, within the wound bed, and on periwound tissues. Bacterial visualisation in real-time helped to guide: (1) bioburden-based, personalised treatment regimens, (2) clinician selection of NPWT, with or without instillation of wound cleansers, and (3) the extent and location of wound cleaning during dressing changes. The ability to visualise bacteria before removal of dressings led to expedited dressing changes when heavy bioburden was detected and postponement of dressing changes for 24 hours when red fluorescence was not observed, avoiding unnecessary disturbance of the wound bed. Conclusion: Fluorescence imaging of bacteria prompted and helped guide the timing of dressing changes, the extent of wound cleaning, and selection of the appropriate and most cost-effective NPWT (standard versus instillation). These results highlight the capability of bacterial fluorescence imaging to provide invaluable real-time information on a wound's bioburden, contributing to clinician treatment decisions in cases where bacterial contamination could impede wound healing.

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