Influence of low-power luminescent red light on recovery of contractile function of the heart in the post-ischemic period

1997 ◽  
Author(s):  
Svetlana L. Malinovskaya ◽  
Olga V. Drugova ◽  
Victor A. Monich ◽  
Irina V. Mukhina
Keyword(s):  
Low Power ◽  
Contractile Function ◽  
Red Light ◽  
Ischemic Period

Myocardial bioenergetics during acute hibernation

1997 ◽  
Vol 273 (3) ◽  
pp. H1452-H1463 ◽  
Author(s):  
J. Zhang ◽  
Y. Ishibashi ◽  
Y. Zhang ◽  
M. H. Eijgelshoven ◽  
D. J. Duncker ◽  
...  
Keyword(s):  
Blood Flow ◽  
Contractile Function ◽  
Creatine Phosphate ◽  
Wall Thickening ◽  
Resonance Spectroscopy ◽  
Blood Flow Ratio ◽  
Ischemic Period ◽  
Myocardial O2 Consumption ◽  
Final Extent ◽  
Myocardial Bioenergetics

During moderate reductions of blood flow, the myocardium downregulates contractile function and ATP utilization to result in reduced but stable ATP levels, recovery or stability of (reduced) creatine phosphate (CP), and preservation of myocyte viability. The intent of this study was to determine the influence of the level of ischemic blood flow and the major determinants of myocardial O2 consumption (MVO2) (heart rate and systolic blood pressure) on recovery of CP during prolonged moderate myocardial hypoperfusion. 31P-nuclear magnetic resonance spectroscopy was used to measure CP, ATP, and Pi in the subepicardium (Epi) and subendocardium (Endo) of 13 open-chest dogs. Wall thickening was measured with sonomicrometry. A coronary stenosis reduced mean myocardial blood flow (microspheres) from 1.10 +/- 0.07 to 0.71 +/- 0.06 ml.g-1.min-1 (P < 0.01) and the Endo-to-Epi blood flow ratio from 1.12 +/- 0.07 to 0.59 +/- 0.06 (P < 0.01), and dyskinesis developed. Coronary blood flow and systolic wall thickening did not change significantly during 4 h of hypoperfusion. Epi CP and ATP fell to 80 +/- 4% (P < 0.05) and 93 +/- 3% of control, respectively, at 30 min. Epi CP then recovered to 87 +/- 5% while ATP decreased further to 83 +/- 5% of baseline by the end of the 240-min ischemic period. Endo CP and ATP fell to 53 +/- 4 and 77 +/- 5% of control, respectively, at 30 min; then Endo CP recovered to 85 +/- 6% while ATP decreased further to 68 +/- 6% of baseline at 240 min of hypoperfusion. ADP levels were significantly increased at 30 min but recovered to baseline by 240 min of hypoperfusion. delta Pi/CP increased significantly (Endo > Epi) at the onset of ischemia and then progressively decreased. At 30 min, mild myocardial acidosis was observed in some hearts with variable pH recovery during continuing hypoperfusion. The data demonstrate that variations in blood flow cannot account for the magnitude of the initial fall in CP or for the final extent of recovery. However, the rate at which CP recovered was significantly correlated with the level of blood flow. Variations in the determinants of MVO2 did not account for differences in CP recovery.

Effect of low-power red light laser irradiation on the viability of human skin fibroblast

1998 ◽  
Vol 37 (3) ◽  
pp. 215-217 ◽  
Author(s):  
Katarzyna Bednarska ◽  
Błażej Rózga ◽  
Krzysztof Kołodziejczyk ◽  
Dorota Szosland ◽  
Wanda Leyko ◽  
...  
Keyword(s):  
Low Power ◽  
Laser Irradiation ◽  
Human Skin ◽  
Skin Fibroblast ◽  
Red Light ◽  
Human Skin Fibroblast ◽  
Red Light Laser

Effect of low-power luminescent red light on processes of lipid peroxidation in myocardial tissues in rats after ischemia

1997 ◽  
Author(s):  
Svetlana L. Malinovskaya ◽  
Kladia N. Kontorshchikova ◽  
Olga V. Drugova ◽  
Victor A. Monich ◽  
Irina V. Mukhina
Keyword(s):  
Lipid Peroxidation ◽  
Low Power ◽  
Red Light

Abnormal lanthanum accumulation due to ischemia in isolated myocardium: effect of chlorpromazine

1981 ◽  
Vol 241 (5) ◽  
pp. H714-H723 ◽  
Author(s):  
K. P. Burton ◽  
H. K. Hagler ◽  
J. T. Willerson ◽  
L. M. Buja
Keyword(s):  
Membrane Permeability ◽  
Contractile Function ◽  
Membrane Integrity ◽  
Cell Integrity ◽  
Inhibitory Effects ◽  
Contractile Parameters ◽  
Ischemic Period ◽  
Isolated Myocardium ◽  
Recovery Response ◽  
Permeability Alterations

The progression of functional, structural, and membrane permeability alterations in the isolated, perfused rabbit interventricular septal preparation was examined at 1, 1.5 or 2 h of ischemia and during 1 h of postischemic reflow. Two other groups of rabbits were pretreated with chlorpromazine (15 and 25 mg/kg), a drug with inhibitory effects on Ca influx and phospholipase activation. The ability of the septa to contract decreased markedly during the ischemic period, but a graded recovery response in physiological contractile parameters was observed upon reperfusion. In septa with comparable preischemic contractile function, pretreatment with chlorpromazine resulted in better functional recovery than that of nontreated septa. Ultrastructural examination showed more extensive and severe damage with increasing periods of ischemia. Ionic La-probe studies of altered membrane integrity showed extensive abnormal intracellular La deposition with ischemic periods of 1.5 h or longer followed by reperfusion. Septa pretreated with chlorpromazine showed better preservation of cell integrity and less intracellular lanthanum deposition. Thus, in this model, a good correlation was found between the extent of functional, structural, and membrane permeability alterations caused by ischemia, and a protective effect of chlorpromazine was shown.

Photoreduction and light-induced triplet-state formation in a single-site fluoroalkylated zinc phthalocyanine

2014 ◽  
Vol 43 (40) ◽  
pp. 14942-14948 ◽  
Author(s):  
Hans Moons ◽  
Andrei Loas ◽  
Sergiu M. Gorun ◽  
Sabine Van Doorslaer
Keyword(s):  
Excited State ◽  
Low Power ◽  
Triplet State ◽  
State Formation ◽  
Red Light ◽  
Single Site ◽  
Zinc Phthalocyanine ◽  
Light Illumination ◽  
Triplet Excited State ◽  
Uv Illumination

Anaerobic red-light illumination leads to reduction of perfluoroisopropyl-substituted zinc(ii) phthalocyanine in ethanol, while low power UV illumination favours the formation of a triplet excited state.

Phototherapeutic effect of low-power red light on processes of lipid peroxidation in myocardium tissues of rats after ischemia

2000 ◽  
Author(s):  
Olga V. Drugova ◽  
Olesya Zhitnikova ◽  
Victor A. Monich ◽  
Irina V. Mukhina
Keyword(s):  
Lipid Peroxidation ◽  
Low Power ◽  
Red Light
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