Selective gastrointestinal uptake of ALA and its benefits for laserlight-induced fluorescence diagnostics (LIFD) and photodynamic therapy (PDT)

1997 ◽  
Author(s):  
Jochen Pressmar ◽  
Josef Stern ◽  
J. Boehm ◽  
B. Kohl ◽  
Johannes Gahlen
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Diagnostics ◽  
Gastrointestinal Uptake

scholarly journals Photodynamic therapy in interplay with fluorescence diagnostics in the treatment of human superficial malignancies

1992 ◽  
Author(s):  
Torsten Andersson ◽  
Roger Berg ◽  
Jonas Johansson ◽  
Dick Killander ◽  
Katarina Svanberg ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Diagnostics

scholarly journals Development of a video fluorescence registration system for a LED emitter

2021 ◽  
Vol 2058 (1) ◽  
pp. 012026
Author(s):  
A V Nekhoroshev ◽  
M V Loshenov ◽  
V B Loschenov
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Practice ◽  
Fluorescence Signal ◽  
Registration System ◽  
Fluorescent Signal ◽  
New Device ◽  
Fluorescence Diagnostics ◽  
Effective Use ◽  
New Devices

Abstract Photodynamic therapy (PDT) is widely implemented in clinical practice. This contributes to the development of new devices for conducting fluorescence diagnostics (FD) and PDT. One of the key parameters for the new devices is the ability to perform PDT and evaluate the fluorescence signal during PDT. Most PDT devices do not have the ability to perform PD and register a fluorescent signal, which is important for monitoring the quality of treatment. The purpose of this work is to develop a new device that will be able to conduct PD and PDT during the operation. Using a video system with software for it and an LED irradiator with several types of LEDs. The results show the effective use of this system and the ability to observe FD, as well as conduct.

Fluorescence diagnostics and photodynamic therapy: prospects of application in gynecological and oncogynecological practice

2021 ◽  
Vol 21 (3) ◽  
pp. 37
Author(s):  
N.V. Zarochentseva ◽  
E.V. Filonenko ◽  
I.I. Baranov ◽  
O.V. Rovinskaya ◽  
O.I. Trushina ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Diagnostics ◽  
Prospects Of Application

Photodynamic therapy and fluorescence diagnostics of breast cancer metastases with photosense and alasense

2002 ◽  
Author(s):  
Elena G. Vakoulovskaya ◽  
Victor V. Shental ◽  
Victor P. Letyagin ◽  
Vitaly J. Brjezovsky ◽  
L. V. Oumnova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Breast Cancer Metastases ◽  
Cancer Metastases ◽  
Fluorescence Diagnostics

Fluorescence diagnostics and photodynamic therapy of grain crops pathogenic fungi

2020 ◽  
Author(s):  
E.V. Akhlyustina ◽  
I.R. Bikmukhametova ◽  
D.V. Pominova ◽  
A.V. Ryabova ◽  
P.V. Grachev ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Pathogenic Fungi ◽  
Grain Crops ◽  
Fluorescence Diagnostics

scholarly journals Investigation of the phenomenon of photobleaching and evaluation of the effectiveness of treatment using a led photodynamic therapy device on optical phantoms

2021 ◽  
Vol 2058 (1) ◽  
pp. 012034
Author(s):  
D A Glechik ◽  
V B Loschenov
Keyword(s):  
Oxidative Stress ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Mortality Rate ◽  
Protoporphyrin Ix ◽  
Spectral Measurements ◽  
Cancer Treatments ◽  
Fluorescence Diagnostics ◽  
Oncological Diseases ◽  
Tissue Fluorescence

Abstract The mortality rate from various oncological diseases remains consistently extremely high, even in spite of recent breakthrough discoveries in the field of cancer therapy [1-3]. One of the most promising cancer treatments is photodynamic therapy (PDT) combined with fluorescence diagnostics (FD) [4, 5]. This study aims to evaluate the efficiency of the PDT procedure using an experimental LED device for photodynamic therapy and fluorescence diagnostics of neoplasms by the level of photobleaching of the photosensitizer protoporphyrin IX (PPIX) in optical phantoms of the skin. The results of spectral measurements showed that the LEDs is able to effectively induce oxidative stress in cancer cells, and due to the presence of a video system, it becomes possible to register the level of tissue fluorescence.

scholarly journals Fluorescence diagnostics and photodynamic therapy of squamous cell carcinoma of the lateral surface of the tongue using the photosensitizer chlorin e6 by spectroscopic video fluorescence methods

2021 ◽  
Vol 2058 (1) ◽  
pp. 012021
Author(s):  
A Kulichenko ◽  
D S Farrakhova ◽  
D V Yakovlev ◽  
Yu S Maklygina ◽  
A A Shiryaev ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Lateral Surface ◽  
Molecular Form ◽  
Chlorin E6 ◽  
Malignant Neoplasms ◽  
Endoscopic Video ◽  
Fluorescence Diagnostics ◽  
Actual Size

Abstract This paper presents the results of using intraoperative fluorescence diagnostics (FD) with the endoscopic video system to increase the efficiency of photodynamic therapy (PDT). The molecular form of chlorin e6 was used as a photosensitizer (PS). All patients received an intravenous administration drug based on chlorin e6 at the concentration of 1 mg/kg. Diagnostics and therapy were carried out in 4 patients diagnosed by malignant neoplasms of the lateral surface of the tongue. Determination of the boundaries by changing the signal of the fluorescence intensity of the tumor was carried out before PDT and after PDT. The efficiency of PDT was assessed by the fluorescent signal of the tumor decreasing when compared with non-pathological normal tissue. The FD method allows to determine accurately the actual size of the tumor and its borders. All patients underwent PDT influenced by the therapeutic laser with a generation wavelength of 660 nm. It is shown that the using of fluorescence diagnostics improves the quality of the photodynamic therapy, since it is possible to assess the photobleaching of the drug during the operation.

scholarly journals Phototheranostics of Cervical Neoplasms with Chlorin e6 Photosensitizer

Cancers ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 211
Author(s):  
Aida Gilyadova ◽  
Anton Ishchenko ◽  
Artem Shiryaev ◽  
Polina Alekseeva ◽  
Kanamat Efendiev ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Human Papillomavirus ◽  
Laser Excitation ◽  
Chlorin E6 ◽  
Laser Source ◽  
Cervical Neoplasms ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Fluorescence Diagnostics ◽  
Hpv Types

(1) Purpose: Improving the treatment effectiveness of intraepithelial neoplasia of the cervix associated with human papillomavirus infection, based on the application of the method of photodynamic therapy with simultaneous laser excitation of fluorescence to clarify the boundaries of cervical neoplasms. (2) Methods: Examination and treatment of 52 patients aged 22 to 53 years with morphologically and cytologically confirmed mild to severe intraepithelial cervix neoplasia, preinvasive, micro-invasive, and squamous cell cervix carcinoma. All patients were carriers of human papillomavirus infection. The patients underwent photodynamic therapy with simultaneous laser excitation of fluorescence. The combined use of video and spectral fluorescence diagnostics for cervical neoplasms made it possible to control the photodynamic therapy process at all stages of the procedure. Evaluation of the photodynamic therapy of intraepithelial cervical neoplasms was carried out with colposcopic examination, cytological conclusion, and morphological verification of the biopsy material after the photodynamic therapy course. The success of human papillomavirus therapy was assessed based on the results of the polymerase chain reaction. (3) Results. The possibility of simultaneous spectral fluorescence diagnostics and photodynamic therapy using a laser source with a wavelength of 660 nm has been established, making it possible to assess the fluorescence index in real-time and control the photobleaching of photosensitizers in the irradiated area. The treatment of all 52 patients was successful after the first photodynamic therapy procedure. According to the PCR test of the discharge from the cervical canal, the previously identified HPV types were not observed in 48 patients. Previously identified HPV types were absent after repeated PDT in four patients (CIN III (n = 2), CIS (n = 2)). In 80.8% of patients, regression of the lesion was noted. (4) Conclusions. The high efficiency of photodynamic therapy with intravenous photosensitizer administration of chlorin e6 has been demonstrated both in relation to eradication therapy of human papillomavirus and in relation to the treatment of intraepithelial lesions of the cervix.

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