System for the comprehensive analysis of multiple sclerosis lesion load based on MR imagery

1997 ◽  
Author(s):  
Jayaram K. Udupa ◽  
Luogang Wei ◽  
Yukio Miki ◽  
Robert I. Grossman
Keyword(s):  
Multiple Sclerosis ◽  
Comprehensive Analysis ◽  
Multiple Sclerosis Lesion ◽  
Lesion Load ◽  
Title System

Quantification of multiple sclerosis lesion load and brain tissue volumetry using multiparameter MRI: methodology and reproducibility

2005 ◽  
Vol 23 (3) ◽  
pp. 445-452 ◽  
Author(s):  
Zhaohua Ding ◽  
Jana Preiningerova ◽  
Christopher J. Cannistraci ◽  
Timothy L. Vollmer ◽  
John C. Gore ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Tissue ◽  
Multiple Sclerosis Lesion ◽  
Lesion Load

scholarly journals HLA-DQA1*04:01 is related to a higher multiple sclerosis lesion load on T2/Flair MRI sequences

2021 ◽  
Author(s):  
Fabio NORO ◽  
Soniza Vieira ALVES-LEON ◽  
Fabricia Lima FONTES-DANTAS ◽  
Paulo Roberto VALLE BAHIA ◽  
Rodrigo Ferrone ANDREIUOLO ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphisms ◽  
Polymerase Chain Reaction Amplification ◽  
Multiple Sclerosis Lesion ◽  
Nucleotide Polymorphisms ◽  
Lesion Load ◽  
Single Nucleotide ◽  
Hla Alleles ◽  
Mri Sequences ◽  
Hla Dqa1

ABSTRACT Background: The genetic predisposition to multiple sclerosis (MS) is associated with HLA alleles, especially HLA-DRB1*15:01. Objective: To identify associations between findings in magnetic resonance imaging (MRI) and genetic features in a Brazilian cohort of patients with MS. Methods: We retrospectively studied data from 95 consecutive patients with MS. Two independent observers who were blinded to the clinical data identified black holes and enhanced lesions on T1 MRI sequences, and counted and measured contrast-enhanced lesions on T2 and Flair (fluid attenuation inversion recovery) sequences. Cases were classified according to lesion size, number, and volume. The HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles, and the rs4774, rs3087456, rs6897932, rs731236, and rs1033182 single nucleotide polymorphisms were identified by polymerase chain reaction amplification with sequence-specific primers using the One Lambda Inc. Kit, Canoga Park, CA, USA. Results: Patients with the HLA-DQA1*04:01 allele had lesion load (adjusted for age, sex, and MS duration) above median compared with patients with other HLA-DQA1 alleles (p=0.02). There were no differences among all the other HLA alleles and single nucleotide polymorphisms and lesion load. Conclusions: The correlation of the HLA-DQA1*04:01 allele with a higher lesion load on T2/Flair MRI sequences suggests that the presence of this allele is associated with the risk of greater MS severity.

Automatic multiple sclerosis lesion detection in brain MRI by FLAIR thresholding

2014 ◽  
Vol 115 (3) ◽  
pp. 147-161 ◽  
Author(s):  
Mariano Cabezas ◽  
Arnau Oliver ◽  
Eloy Roura ◽  
Jordi Freixenet ◽  
Joan C. Vilanova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Mri ◽  
Lesion Detection ◽  
Multiple Sclerosis Lesion
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