Multimodal OCT for in-vivo diagnosis of vulvar lichen sclerosus and evaluate the therapy success

2021 ◽  
Author(s):  
Marina A. Sirotkina ◽  
Arseny L. Potapov ◽  
Maria M. Karabut ◽  
Nailya N. Vagapova ◽  
Alexander A. Moiseev ◽  
...  
Keyword(s):  
Lichen Sclerosus ◽  
In Vivo Diagnosis ◽  
Therapy Success ◽  
Vulvar Lichen Sclerosus

Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus

2001 ◽  
Vol 11 (2) ◽  
pp. 113-118 ◽  
Author(s):  
K. J. Rolfe ◽  
L. J. Eva ◽  
A. B. Maclean ◽  
J. C. Crow ◽  
C. W. Perrett ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Molecular Markers ◽  
Lichen Sclerosus ◽  
Malignant Change ◽  
Cell Cycle Proteins ◽  
Vulvar Lichen Sclerosus

scholarly journals Aptamer Applications in Emerging Viral Diseases

2021 ◽  
Vol 14 (7) ◽  
pp. 622
Author(s):  
Arne Krüger ◽  
Ana Paula de Jesus Santos ◽  
Vanessa de Sá ◽  
Henning Ulrich ◽  
Carsten Wrenger
Keyword(s):  
Virus Assembly ◽  
Viral Diseases ◽  
Tissue Penetration ◽  
Rna Molecules ◽  
Viral Particles ◽  
Pharmacokinetic Properties ◽  
Oligonucleotide Library ◽  
In Vivo Diagnosis ◽  
Emerging Viral Diseases

Aptamers are single-stranded DNA or RNA molecules which are submitted to a process denominated SELEX. SELEX uses reiterative screening of a random oligonucleotide library to identify high-affinity binders to a chosen target, which may be a peptide, protein, or entire cells or viral particles. Aptamers can rival antibodies in target recognition, and benefit from their non-proteic nature, ease of modification, increased stability, and pharmacokinetic properties. This turns them into ideal candidates for diagnostic as well as therapeutic applications. Here, we review the recent accomplishments in the development of aptamers targeting emerging viral diseases, with emphasis on recent findings of aptamers binding to coronaviruses. We focus on aptamer development for diagnosis, including biosensors, in addition to aptamer modifications for stabilization in body fluids and tissue penetration. Such aptamers are aimed at in vivo diagnosis and treatment, such as quantification of viral load and blocking host cell invasion, virus assembly, or replication, respectively. Although there are currently no in vivo applications of aptamers in combating viral diseases, such strategies are promising for therapy development in the future.

scholarly journals 310 A new proposal for the clinical classification of vulvar lichen sclerosus: an observational prospective study

2020 ◽  
Author(s):  
Veronica Boero ◽  
Carlo A Liverani ◽  
Massimiliano Brambilla ◽  
Ermelinda Monti ◽  
Filippo Murina ◽  
...  
Keyword(s):  
Prospective Study ◽  
Lichen Sclerosus ◽  
Clinical Classification ◽  
Observational Prospective Study ◽  
Vulvar Lichen Sclerosus

Clearance in vulvar lichen sclerosus: a realistic treatment endpoint or a chimera?

2017 ◽  
Vol 32 (1) ◽  
pp. 96-101 ◽  
Author(s):  
A. Borghi ◽  
A. Virgili ◽  
S. Minghetti ◽  
G. Toni ◽  
M. Corazza
Keyword(s):  
Lichen Sclerosus ◽  
Treatment Endpoint ◽  
Vulvar Lichen Sclerosus
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