Brain tumor margin detection using 1.7-μm spectroscopic swept-source OCT

2021 ◽  
Author(s):  
Tae Il Yoon ◽  
Jae Sung Park ◽  
Byeong Ha Lee ◽  
Tae Joong Eom
Keyword(s):  
Brain Tumor ◽  
Swept Source ◽  
Tumor Margin ◽  
Swept Source Oct ◽  
Margin Detection

Spectro-Temporal Autofluorescence Contrast–Based Imaging for Brain Tumor Margin Detection and Biobanking

2017 ◽  
pp. 355-368
Author(s):  
Asael Papour ◽  
Zach Taylor ◽  
Linda Liau ◽  
William H. Yong ◽  
Oscar Stafsudd ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Margin ◽  
Margin Detection

305 Speckle-Free and Large Gold Nanorod Enhanced Optical Coherence Tomography for Brain Tumor Margin Detection

Neurosurgery ◽  
2017 ◽  
Vol 64 (CN_suppl_1) ◽  
pp. 264-264 ◽  
Author(s):  
Derek W Yecies ◽  
Orly Liba ◽  
Elliot SoRelle ◽  
Rebecca Dutta ◽  
Christy Wilson ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Brain Tumor ◽  
Ex Vivo ◽  
Cellular Level ◽  
Large Field ◽  
Optical Coherence ◽  
Tumor Margin ◽  
Oct Imaging ◽  
Margin Detection

Abstract INTRODUCTION Optical coherence tomography (OCT) is an emerging technology with the potential to allow for rapid intraoperative detection of brain tumor margins by detecting differences in structure, intensity, spectral signal, and attenuation. OCT systems are capable of rapid imaging of large three-dimensional volumes with cellular level resolution. However, OCT imaging has previously been limited by speckle artifact and the lack of suitable contrast agents, limitations that are surmounted in this study. METHODS We prepared nude mice with orthotopic U87 glioblastoma xenografts and glass cranial windows. We also created large gold nanorods (LGNR) with plasmonic peaks tuned to the spectral range of the OCT scanner. LGNRs were injected intravenously into tumor-bearing mice and OCT imaging was performed in vivo utilizing a novel method for the removal of speckle artifact called Speckle-Free OCT (SFOCT). Fresh ex-vivo patient samples were also imaged. RESULTS >OCT and SFOCT readily distinguished tumor from normal brain with cellular level spatial resolution and to a depth of 1.5 mm. Additionally, SFOCT allowed for the highest resolution ever seen in vivo of mouse white matter architecture. Cortical layers were also readily visible in SFOCT in both live mice and in the ex-vivo human samples, representing a novel ability to interrogate cortical cytoarchitecture across a large field of view. Systemically administered LGNRs were tumor specific and provided excellent spectral contrast using OCT. Ex-vivo hyperspectral and IHC imaging confirmed the localization of LGNRs within the tumor and found that the LGNRs were largely localized within tumor associated macrophages. CONCLUSION SFOCT and LGNR enhanced OCT imaging are promising state of the art technologies for intraoperative tumor margin detection.

scholarly journals Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Derek Yecies ◽  
Orly Liba ◽  
Elliott D. SoRelle ◽  
Rebecca Dutta ◽  
Edwin Yuan ◽  
...  
Keyword(s):  
Brain Tumor ◽  
High Resolution ◽  
Human Brain ◽  
Wide Field ◽  
Human Brain Tumor ◽  
Tumor Margin ◽  
Margin Detection

scholarly journals High-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging

2018 ◽  
Author(s):  
Derek Yecies ◽  
Orly Liba ◽  
Elliott SoRelle ◽  
Rebecca Dutta ◽  
Edwin Yuan ◽  
...  
Keyword(s):  
Brain Tumor ◽  
White Matter ◽  
Ex Vivo ◽  
Field Of View ◽  
Low Grade ◽  
Wide Field ◽  
Tumor Margin ◽  
Wide Field Of View ◽  
Margin Detection

AbstractCurrent in vivo neuroimaging techniques provide limited field of view or spatial resolution and often require exogenous contrast. These limitations prohibit detailed structural imaging across wide fields of view and hinder intraoperative tumor margin detection. Here we present a novel neuroimaging technique, speckle-modulating optical coherence tomography (SM-OCT), which allows us to image the brains of live mice and ex vivo human samples with unprecedented resolution and wide field of view using only endogenous contrast. The increased effective resolution provided by speckle elimination reveals white matter fascicles and cortical layer architecture in the brains of live mice. To our knowledge, the data reported herein represents the highest resolution imaging of murine white matter structure achieved in vivo across a wide field of view of several millimeters. When applied to an orthotopic murine glioblastoma xenograft model, SM-OCT readily identifies brain tumor margins with near single-cell resolution. SM-OCT of ex vivo human temporal lobe tissue reveals fine structures including cortical layers and myelinated axons. Finally, when applied to an ex vivo sample of a low-grade glioma resection margin, SM-OCT is able to resolve the brain tumor margin. Based on these findings, SM-OCT represents a novel approach for intraoperative tumor margin detection and in vivo neuroimaging.

scholarly journals Feasibility of peripheral OCT imaging using a novel integrated SLO ultra-widefield imaging swept-source OCT device

2021 ◽  
Author(s):  
Simrat K. Sodhi ◽  
John Golding ◽  
Carmelina Trimboli ◽  
Netan Choudhry
Keyword(s):  
Posterior Pole ◽  
Field Of View ◽  
Retinal Diseases ◽  
Swept Source ◽  
Full Field ◽  
Swept Source Oct ◽  
Oct Imaging ◽  
Field Device ◽  
Areas Of Interest ◽  
Retinal Pathologies

Abstract Purpose To describe the feasibility of peripheral OCT imaging in retinal diseases using a novel full-field device. Methods A total of 134 consecutive eyes were referred and imaged on the Optos Silverstone swept-source OCT (SS-OCT) (Optos PLC; Dunfermline, UK). Scanning laser ophthalmoscope (SLO) images and the associated SS-OCT images were obtained in the posterior pole, mid-periphery or far periphery based on the nature of the referral and on new areas of interest observed in the optomap images at the time of imaging. Results A total of 134 eyes (96 patients) were enrolled in the study. One hundred and twenty-five eyes (91 patients) with 38 retinal pathologies were prospectively assessed and 9 eyes (5 patients) were excluded due to incomplete image acquisition. The average age of the subjects was 54 years (range 21–92 years). Thirty-nine out of 125 eyes (31%) had macular pathologies. Eighty-six out of 125 eyes (69%) had peripheral only pathologies, an area which cannot be visualized by standard OCT devices with a 50 degree field-of-view. Conclusions The ability to capture peripheral pathologies using an integrated SLO-UWF imaging with full-field swept-source provided high-grade anatomical insight that confirmed the medical and surgical management in a majority of cases. Its use in the mid- and far periphery provides a holistic clinical picture, which can potentially aid in the understanding of various retinal pathologies.

scholarly journals Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation

2015 ◽  
Vol 23 (5) ◽  
pp. 5508 ◽  
Author(s):  
Meena Siddiqui ◽  
Serhat Tozburun ◽  
Ellen Ziyi Zhang ◽  
Benjamin J. Vakoc
Keyword(s):  
Swept Source ◽  
Complex Demodulation ◽  
Swept Source Oct
Sign in / Sign up

Export Citation Format

Share Document