Motor cortex hemodynamic response function in freely moving subjects recorded via time domain fNIRS

2021 ◽  
Author(s):  
Michele Lacerenza ◽  
Mauro Buttafava ◽  
Lorenzo Spinelli ◽  
Alberto Tosi ◽  
Alberto Dalla Mora ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Response Function ◽  
Time Domain ◽  
Hemodynamic Response ◽  
Hemodynamic Response Function ◽  
Freely Moving

scholarly journals Monitoring the motor cortex hemodynamic response function in freely moving walking subjects: a time-domain fNIRS pilot study

2021 ◽  
Vol 8 (01) ◽  
Author(s):  
Michele Lacerenza ◽  
Lorenzo Spinelli ◽  
Mauro Buttafava ◽  
Alberto Dalla Mora ◽  
Franco Zappa ◽  
...  
Keyword(s):  
Pilot Study ◽  
Motor Cortex ◽  
Response Function ◽  
Time Domain ◽  
Hemodynamic Response ◽  
Hemodynamic Response Function ◽  
Freely Moving

scholarly journals The brain’s hemodynamic response function rapidly changes under acute psychosocial stress in association with genetic and endocrine stress response markers

2018 ◽  
Vol 115 (43) ◽  
pp. E10206-E10215 ◽  
Author(s):  
Immanuel G. Elbau ◽  
Benedikt Brücklmeier ◽  
Manfred Uhr ◽  
Janine Arloth ◽  
Darina Czamara ◽  
...  
Keyword(s):  
Stress Response ◽  
Response Function ◽  
Genetic Variants ◽  
Psychosocial Stress ◽  
Acute Stress ◽  
Physiological Stress ◽  
Hemodynamic Response ◽  
Hemodynamic Response Function ◽  
Ample Evidence ◽  
Acute Psychosocial Stress

Ample evidence links dysregulation of the stress response to the risk for psychiatric disorders. However, we lack an integrated understanding of mechanisms that are adaptive during the acute stress response but potentially pathogenic when dysregulated. One mechanistic link emerging from rodent studies is the interaction between stress effectors and neurovascular coupling, a process that adjusts cerebral blood flow according to local metabolic demands. Here, using task-related fMRI, we show that acute psychosocial stress rapidly impacts the peak latency of the hemodynamic response function (HRF-PL) in temporal, insular, and prefrontal regions in two independent cohorts of healthy humans. These latency effects occurred in the absence of amplitude effects and were moderated by regulatory genetic variants of KCNJ2, a known mediator of the effect of stress on vascular responsivity. Further, hippocampal HRF-PL correlated with both cortisol response and genetic variants that influence the transcriptional response to stress hormones and are associated with risk for major depression. We conclude that acute stress modulates hemodynamic response properties as part of the physiological stress response and suggest that HRF indices could serve as endophenotype of stress-related disorders.

Retinotopic variations of the negative blood-oxygen-level dependent hemodynamic response function in human primary visual cortex

2021 ◽  
Vol 125 (4) ◽  
pp. 1045-1057 ◽  
Author(s):  
Natasha de la Rosa ◽  
David Ress ◽  
Amanda J. Taylor ◽  
Jung Hwan Kim
Keyword(s):  
Visual Cortex ◽  
Response Function ◽  
Complex Dynamics ◽  
Hemodynamic Response ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Hemodynamic Response Function ◽  
Blood Oxygen Level ◽  
Early Visual Cortex

We investigate dynamics of the negative hemodynamic response function (nHRF), the negative blood-oxygen-level-dependent (BOLD) response (NBR) evoked by a brief stimulus, in human early visual cortex. Here, we show that the nHRFs are not inverted versions of the corresponding pHRFs. The nHRF has complex dynamics that varied significantly with eccentricity. The results also show shift-invariant temporal linearity does not hold for the NBR.

scholarly journals A cortical rat hemodynamic response function for improved detection of BOLD activation under common experimental conditions

NeuroImage ◽  
2020 ◽  
Vol 208 ◽  
pp. 116446 ◽  
Author(s):  
Henriette Lambers ◽  
Martin Segeroth ◽  
Franziska Albers ◽  
Lydia Wachsmuth ◽  
Timo Mauritz van Alst ◽  
...  
Keyword(s):  
Response Function ◽  
Hemodynamic Response ◽  
Hemodynamic Response Function ◽  
Experimental Conditions

scholarly journals Effects of Hemodynamic Response Function Selection on Rat fMRI Statistical Analyses

2019 ◽  
Vol 13 ◽  
Author(s):  
Shin-Lei Peng ◽  
Chun-Ming Chen ◽  
Chen-You Huang ◽  
Cheng-Ting Shih ◽  
Chiun-Wei Huang ◽  
...  
Keyword(s):  
Response Function ◽  
Hemodynamic Response ◽  
Statistical Analyses ◽  
Hemodynamic Response Function ◽  
Function Selection

scholarly journals Concurrent fMRI and optical measures for the investigation of the hemodynamic response function

2005 ◽  
Vol 54 (2) ◽  
pp. 354-365 ◽  
Author(s):  
Aneurin J. Kennerley ◽  
Jason Berwick ◽  
John Martindale ◽  
David Johnston ◽  
Nikos Papadakis ◽  
...  
Keyword(s):  
Response Function ◽  
Hemodynamic Response ◽  
Hemodynamic Response Function
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