Fluorescence lifetime optical biopsy of the hepatocellular carcinoma in murine model

2021 ◽  
Author(s):  
Ksenia Kandurova ◽  
Valery Shupletsov ◽  
Elena Potapova ◽  
Viktor Dremin ◽  
Evgeny Zherebtsov ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fluorescence Lifetime ◽  
Murine Model ◽  
Optical Biopsy

scholarly journals Fluorescence Lifetime Needle Optical Biopsy Discriminates Hepatocellular Carcinoma

2021 ◽  
Author(s):  
Evgeny Zherebtsov ◽  
Elena Potapova ◽  
Andrian Mamoshin ◽  
Valery Shupletsov ◽  
Ksenia Kandurova ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fluorescence Lifetime ◽  
Optical Biopsy

A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma

2013 ◽  
Vol 46 (3) ◽  
pp. 141-152 ◽  
Author(s):  
Masato Fujii ◽  
Yuichiro Shibazaki ◽  
Kyoko Wakamatsu ◽  
Yutaka Honda ◽  
Yusuke Kawauchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Murine Model ◽  
Alcoholic Steatohepatitis

scholarly journals AAV6 Vexosomes Mediate Robust Suicide Gene Delivery in a Murine Model of Hepatocellular Carcinoma

2020 ◽  
Vol 17 ◽  
pp. 497-504 ◽  
Author(s):  
Nusrat Khan ◽  
Shubham Maurya ◽  
Sridhar Bammidi ◽  
Giridhara R. Jayandharan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Delivery ◽  
Murine Model ◽  
Suicide Gene

Su1958 A Novel Murine Model Recapitulates the Pathogenesis of Human Non-Alcoholic Steatohepatitis (NASH) and NASH-Related Hepatocellular Carcinoma

2012 ◽  
Vol 142 (5) ◽  
pp. S-546
Author(s):  
Masato Fujii ◽  
Yuichiro Shibazaki ◽  
Kyoko Wakamatsu ◽  
Taihei Honma ◽  
Taishi Hashiguchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Murine Model ◽  
Alcoholic Steatohepatitis

Bone Marrow Mesenchymal Stem Cells Exhibit a Transdifferentiation and Therapeutic Effects in a Murine Model of Orthotopic Hepatocellular Carcinoma.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5133-5133
Author(s):  
Jun Ren ◽  
Hanfang Jiang ◽  
Lijun Di ◽  
Guohong Song
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Murine Model ◽  
Therapeutic Potential ◽  
Therapeutic Effects ◽  
Tumor Diameter ◽  
Hepatic Differentiation ◽  
Marrow Mesenchymal Stem Cells

Abstract Background and Aim: Bone marrow stem cells can differentiate into mature hepatocytes in vitro and in vivo. Moreover, recent study shown bone marrow mesenchymal stem cells (MSCs) are the most potent component in hepatic differentiation, suggesting that the transplantation of MSCs is a promising treatment for liver disease. However, little information is available about the therapeutic potential of MSCs transplantation in cases of hepatic cell carcinoma (HCC). Here, we transplanted bone marrow-derived MSCs to testify their effects in a murine model of orthotopic HCC. Methods:MSCs were obtained from tow male strains of β-galactosidase (β-gal) transgenic mouse(Rosa 26) and BALB/c mouse. MSCs were injected into tumor in BALB/c femal murine models of orthotopic HCC. Tumor growths were assessed by MRI on 7 days and survival rates were observed. When mouse was dying, the liver was removed from each treated mouse and evaluated by x-gal staining, and immunohistochemisty as well. Results: MSCs transplantation increased the survival of hepatocellular carcinoma-bearing mice(25.5±4.5days verus 21.3±1.7days, p=0.025) and decreased tumor diameter slightly (7.7±2.9mm versus 9.4±2.8mm, p=0.284). MSCs transplanted directly into the tumor and/ or normal hepatic parenchyma in the same liver lobe localized mainly at the border between the tumor cells and normal liver parenchyma, induced a large area of coagulative necrosis in the tumor bed. Some engrafted MSCs were positive for albumin. There are in the carcinoma bearing BALB/c mice with MSCs implanted, whether MSCs from BALB/c mice or from Rosa 26 transgenic mice. Conclusion: Our results suggest that the therapeutical effects of MSCs might be mediated not only by their differentiation into hepatocyte, but also mainly by they possess intrinsic antineoplastic properties.

520 Magnetic resonance imaging of a murine model for hepatocellular carcinoma

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 409-409
Author(s):  
S HIOTIS ◽  
Y WADGHIRI ◽  
H YEE ◽  
W LUAN ◽  
S BURAKOFF
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hepatocellular Carcinoma ◽  
Magnetic Resonance ◽  
Murine Model ◽  
Resonance Imaging

scholarly journals Tumor control by human cytomegalovirus in a murine model of hepatocellular carcinoma

2016 ◽  
Vol 3 ◽  
pp. 16012 ◽  
Author(s):  
Amit Kumar ◽  
Laurie Coquard ◽  
Sébastien Pasquereau ◽  
Laetitia Russo ◽  
Séverine Valmary-Degano ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Human Cytomegalovirus ◽  
Murine Model ◽  
Tumor Control
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