Development of fluorescence cystoscope system for extension of diagnosis depth in 5-aminolevulinic acid mediated photodynamic diagnosis of bladder cancer

2021 ◽  
Author(s):  
Hiroki Takishima ◽  
Takahiro Nishimura ◽  
Hisanao Hazama ◽  
Hideo Fukuhara ◽  
Keiji Inoue ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Aminolevulinic Acid ◽  
Photodynamic Diagnosis

scholarly journals Fluorescence Enhancement Effect of TiO2 Nanoparticles and Application for Photodynamic Diagnosis

2019 ◽  
Vol 20 (15) ◽  
pp. 3698 ◽  
Author(s):  
Koki Kanehira ◽  
Yukiko Yano ◽  
Hisashi Hasumi ◽  
Hideo Fukuhara ◽  
Keiji Inoue ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Titanium Dioxide ◽  
Polyethylene Glycol ◽  
Fluorescence Enhancement ◽  
Aminolevulinic Acid ◽  
Titanium Dioxide Nanoparticles ◽  
Photodynamic Diagnosis ◽  
Enhancement Effect ◽  
Bladder Cancer Cells ◽  
Combined Administration

Photodynamic diagnosis (PDD) can improve diagnostic accuracy by using PDD agents such as 5-aminolevulinic acid (ALA). However, the weakness and photobleaching of fluorescence of PDD agents may lead to insufficient fluorescence visibility for the detection of cancer during resection operations. We focused on the “fluorescence enhancement effect” resulting from the addition of polyethylene glycol-modified titanium dioxide nanoparticles (TiO2-PEG NPs) to address these problems. The results showed that the combined administration of TiO2-PEG NPs and ALA could enhance and prolong fluorescence in bladder cancer cells, similar to in the mixture alone. It was suggested that the fluorescence enhancement was related to the accumulation of TiO2-PEG NPs in cells via endocytosis, causing the light scattering and enhancement of fluorescence. This fluorescence enhancement effect could be applicable for PDD.

scholarly journals Transient liver toxicity as a result of the oral administration of 5‐aminolevulinic acid for photodynamic diagnosis in patients with bladder cancer

2018 ◽  
Vol 26 (2) ◽  
pp. 315-317 ◽  
Author(s):  
Makito Miyake ◽  
Yasushi Nakai ◽  
Shunta Hori ◽  
Yosuke Morizawa ◽  
Yoshihiko Hirao ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Oral Administration ◽  
Liver Toxicity ◽  
Aminolevulinic Acid ◽  
Photodynamic Diagnosis
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