Optimal optical design of aspheric ultrasonic probe for photoacoustic microscopy

2021 ◽  
Author(s):  
Yuwei Zhu ◽  
Huiyan Jiang ◽  
Zouhua Chen ◽  
Xianlin Song
Keyword(s):  
Optical Design ◽  
Photoacoustic Microscopy ◽  
Ultrasonic Probe

Use of the Magnetostatic Analogue In Electromagnetic Lens Engineering

1970 ◽  
Vol 28 ◽  
pp. 360-361
Author(s):  
John W. Coleman
Keyword(s):  
Boundary Conditions ◽  
High Performance ◽  
Force Fields ◽  
Optical Design ◽  
Direct Conversion ◽  
Design Engineering ◽  
Design Data ◽  
Scalar Potentials ◽  
Geometric Elements ◽  
At Will

In the design engineering of high performance electromagnetic lenses, the direct conversion of electron optical design data into drawings for reliable hardware is oftentimes difficult, especially in terms of how to mount parts to each other, how to tolerance dimensions, and how to specify finishes. An answer to this is in the use of magnetostatic analytics, corresponding to boundary conditions for the optical design. With such models, the magnetostatic force on a test pole along the axis may be examined, and in this way one may obtain priority listings for holding dimensions, relieving stresses, etc..The development of magnetostatic models most easily proceeds from the derivation of scalar potentials of separate geometric elements. These potentials can then be conbined at will because of the superposition characteristic of conservative force fields.

Basic Properties of an Ultrasonic Probe with a Through Hole for Puncture and Detection Principle of a Puncture Needle

2012 ◽  
Vol 132 (11) ◽  
pp. 420-424 ◽  
Author(s):  
Yuusuke Tanaka ◽  
Katsuhiko Tanaka ◽  
Susumu Sugiyama ◽  
Hisanori Shiomi ◽  
Yoshimasa Kurumi ◽  
...  
Keyword(s):  
Ultrasonic Probe ◽  
Basic Properties ◽  
Puncture Needle ◽  
Through Hole ◽  
Detection Principle

Optical design to boost the performance of perovskite based tandem solar cells

2018 ◽  
Author(s):  
Miguel Anaya ◽  
Gabriel Lozano ◽  
Mauricio Calvo ◽  
Hernán Míguez
Keyword(s):  
Solar Cells ◽  
Optical Design ◽  
Tandem Solar Cells

Lossless Photon management – Optical design for manufacture at different length scales - NOLOSS - H2020

Impact ◽  
2018 ◽  
Vol 2018 (1) ◽  
pp. 48-50
Author(s):  
Toralf Scharf ◽  
Paul Urbach ◽  
Carsten Rockstuhl ◽  
Frank Setzpfand
Keyword(s):  
Optical Design ◽  
Length Scales ◽  
Design For Manufacture ◽  
Photon Management

scholarly journals Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Yanfeng Dai ◽  
Xiang Yu ◽  
Jianshuang Wei ◽  
Fanxin Zeng ◽  
Yiran Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Scavenger Receptor ◽  
Intradermal Injection ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Surgery ◽  
Photoacoustic Microscopy ◽  
Dual Targeting ◽  
Scavenger Receptor Class ◽  
Distinct Distribution

Abstract Detection of sentinel lymph nodes (SLNs) is critical to guide the treatment of breast cancer. However, distinguishing metastatic SLNs from normal and inflamed lymph nodes (LNs) during surgical resection remains a challenge. Here, we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle (5K-HA-HPPS) loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast cancer. The small sized (~40 nm) self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal injection. Compared with normal popliteal LNs (N-LN), there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs (T-MLN) and inflamed LNs (Inf-LN), respectively, 6 h after nanoparticle inoculation. More importantly, photoacoustic microscopy (PAM) of 5K-HA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and Inf-LN. Signals were mainly distributed at the centre of T-MLN but at the periphery of N-LN and Inf-LN. The ratio of PA intensity (R) at the centre of the LNs compared with that at the periphery was 5.93 ± 0.75 for T-MLNs of the 5K-HA-HPPS group, which was much higher than that for the Inf-LNs (R = 0.2 ± 0.07) and N-LNs (R = 0.45 ± 0.09). These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs, thus guiding the removal of SLNs during breast cancer surgery.

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