Estimation of cerebral O2 consumption with 2-photon phosphorescence microscopy

2021 ◽  
Author(s):  
Anna Devor
Keyword(s):  
O2 Consumption ◽  
Cerebral O2 Consumption

Effects of Up-Regulation of AMPA Receptors on Cerebral O2 Consumption

1998 ◽  
Vol 10 (4) ◽  
pp. 261
Author(s):  
Oak Z Chi ◽  
Arabind K Sinha ◽  
Xia Liu ◽  
Harvey R Weiss
Keyword(s):  
Ampa Receptors ◽  
O2 Consumption ◽  
Cerebral O2 Consumption

Effect of up-regulation of NMDA receptors on cerebral O2 consumption and blood flow in rat

1996 ◽  
Vol 730 (1-2) ◽  
pp. 193-198 ◽  
Author(s):  
Harvey R. Weiss ◽  
Arabinda K. Sinha ◽  
Xiaowen Lu
Keyword(s):  
Blood Flow ◽  
Nmda Receptors ◽  
O2 Consumption ◽  
Cerebral O2 Consumption

Hypercapnia and response of cerebral blood flow to hypoxia in newborn lambs

1989 ◽  
Vol 66 (3) ◽  
pp. 1065-1070 ◽  
Author(s):  
J. Massik ◽  
M. D. Jones ◽  
M. Miyabe ◽  
Y. L. Tang ◽  
M. L. Hudak ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Hypoxic Hypoxia ◽  
Base Line ◽  
O2 Consumption ◽  
Arterial Pco2 ◽  
Cerebral O2 Consumption ◽  
Before And After ◽  
Cervical Ganglion ◽  
Cerebral Vasodilation

Individual effects of hypoxic hypoxia and hypercapnia on the cerebral circulation are well described, but data on their combined effects are conflicting. We measured the effect of hypoxic hypoxia on cerebral blood flow (CBF) and cerebral O2 consumption during normocapnia (arterial PCO2 = 33 +/- 2 Torr) and during hypercapnia (60 +/- 2 Torr) in seven pentobarbital-anesthetized lambs. Analysis of variance showed that neither the magnitude of the hypoxic CBF response nor cerebral O2 consumption was significantly related to the level of arterial PCO2. To determine whether hypoxic cerebral vasodilation during hypercapnia was restricted by reflex sympathetic stimulation we studied an additional six hypercapnic anesthetized lambs before and after bilateral removal of the superior cervical ganglion. Sympathectomy had no effect on base-line CBF during hypercapnia or on the CBF response to hypoxic hypoxia. We conclude that the effects of hypoxic hypoxia on CBF and cerebral O2 consumption are not significantly altered by moderate hypercapnia in the anesthetized lamb. Furthermore, we found no evidence that hypercapnia results in a reflex increase in sympathetic tone that interferes with the ability of cerebral vessels to dilate during hypoxic hypoxia.

Effect of upregulation of AMPA glutamate receptors on cerebral O2 consumption and blood flow in rat

1999 ◽  
Vol 842 (1) ◽  
pp. 230-232 ◽  
Author(s):  
Arabinda K Sinha ◽  
Aasif H Mirza ◽  
Xia Liu ◽  
Oak Z Chi ◽  
Harvey R Weiss
Keyword(s):  
Blood Flow ◽  
Glutamate Receptors ◽  
O2 Consumption ◽  
Ampa Glutamate Receptors ◽  
Cerebral O2 Consumption

Effects of changes in arterial O2 content on cerebral blood flow in the lamb

1981 ◽  
Vol 240 (2) ◽  
pp. H209-H215 ◽  
Author(s):  
M. D. Jones ◽  
R. J. Traystman ◽  
M. A. Simmons ◽  
R. A. Molteni
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
O2 Consumption ◽  
Hematocrit Level ◽  
Cerebral O2 Consumption ◽  
Flow Changes ◽  
O2 Delivery ◽  
Relationship Of ◽  
The Relationship ◽  
Arterial Po2

The effect of variations in arterial O2 content (CaO2) on the cerebrovascular bed of seven unanesthetized newborn lambs was studied as the hematocrit and arterial PO2 (PaO2) were varied. Each subject was studied at a high hematocrit [44 +/- 3% (SD)] and a low hematocrit [24 +/- 3%]. At each hematocrit level the PaO2 was changed over a range of 30-150 mmHg. The relationship between cerebral blood flow and PO2 depended on hematocrit and vice versa. To the contrary, the relationship of blood flow to CaO2 was independent of hematocrit and/or PO/. As CaO2 fell, regardless of whether this was due to a fall in PO2 hematocrit or both, there was a reciprocal increase in cerebral blood flow such that cerebral O2 delivery (cerebral blood flow x CaO2) was constant. These data show that CaO2 is a variable of fundamental importance to the regulation of cerebral blood flow. Changes in CaO2 are accompanied by reciprocal changes in cerebral blood flow to maintain constant cerebral O2 delivery. Data among species with differing cerebral O2 consumption show that cerebral O2 delivery, in turn, is regulated according to cerebral O2 consumption.

17Beta-estradiol blocks NMDA-induced increases in regional cerebral O2 consumption

2002 ◽  
Vol 951 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Harvey R Weiss ◽  
Deepa Doshi ◽  
Arabinda K Sinha ◽  
Xia Liu ◽  
Oak Z Chi
Keyword(s):  
O2 Consumption ◽  
Cerebral O2 Consumption

Reduced effect of stimulation of AMPA receptors on cerebral O2 consumption in a rat model of autism

2012 ◽  
Vol 63 (5) ◽  
pp. 837-841 ◽  
Author(s):  
Harvey R. Weiss ◽  
Xia Liu ◽  
Parneet Grewal ◽  
Oak Z. Chi
Keyword(s):  
Rat Model ◽  
Ampa Receptors ◽  
O2 Consumption ◽  
Cerebral O2 Consumption ◽  
Stimulation Of

EFFECTS OF UP-REGULATION OF AMPA RECEPTORS ON CEREBRAL O2 CONSUMPTION

1998 ◽  
Vol 89 (Supplement) ◽  
pp. 758A
Author(s):  
O Z Chi ◽  
A K Sinha ◽  
X Liu ◽  
H R Weiss
Keyword(s):  
Ampa Receptors ◽  
O2 Consumption ◽  
Cerebral O2 Consumption
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