Harnessing atomic forces for the opto-mechanical manipulation of a mesoscopic object

2021 ◽  
Author(s):  
Cyril Laplane ◽  
James White ◽  
Reece Roberts ◽  
David Inglis ◽  
Thomas Volz
Keyword(s):  
Mechanical Manipulation

Electrical and Mechanical Manipulation of Ferromagnetic Properties in Polycrystalline Nickel Thin Film

2011 ◽  
Vol 2 ◽  
pp. 6000104-6000104 ◽  
Author(s):  
Tao Wu ◽  
A Bur ◽  
J L Hockel ◽  
Kin Wong ◽  
Tien-Kan Chung ◽  
...  
Keyword(s):  
Thin Film ◽  
Polycrystalline Nickel ◽  
Ferromagnetic Properties ◽  
Mechanical Manipulation

scholarly journals Brick Strex: a robust device built of LEGO bricks for mechanical manipulation of cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elina Mäntylä ◽  
Teemu O. Ihalainen
Keyword(s):  
Molecular Mechanisms ◽  
Compressive Force ◽  
Tissue Mechanics ◽  
Cell Junctions ◽  
Physical Factors ◽  
Force Transmission ◽  
Cell Nuclei ◽  
Microscopy Imaging ◽  
Robust Solution ◽  
Mechanical Manipulation

AbstractCellular forces, mechanics and other physical factors are important co-regulators of normal cell and tissue physiology. These cues are often misregulated in diseases such as cancer, where altered tissue mechanics contribute to the disease progression. Furthermore, intercellular tensile and compressive force-related signaling is highlighted in collective cell behavior during development. However, the mechanistic understanding on the role of physical forces in regulation of cellular physiology, including gene expression and signaling, is still lacking. This is partly because studies on the molecular mechanisms of force transmission require easily controllable experimental designs. These approaches should enable both easy mechanical manipulation of cells and, importantly, readouts ranging from microscopy imaging to biochemical assays. To achieve a robust solution for mechanical manipulation of cells, we developed devices built of LEGO bricks allowing manual, motorized and/or cyclic cell stretching and compression studies. By using these devices, we show that $$\upbeta$$ β -catenin responds differentially to epithelial monolayer stretching and lateral compression, either localizing more to the cell nuclei or cell–cell junctions, respectively. In addition, we show that epithelial compression drives cytoplasmic retention and phosphorylation of transcription coregulator YAP1. We provide a complete part listing and video assembly instructions, allowing other researchers to build and use the devices in cellular mechanics-related studies.

Descemet’s Membrane Detachment

2013 ◽  
Author(s):  
Malik Y. Kahook
Keyword(s):  
Surgical Intervention ◽  
Corneal Stroma ◽  
Corneal Edema ◽  
Glaucoma Surgery ◽  
Bullous Keratopathy ◽  
Descemet’S Membrane Detachment ◽  
Descemet's Membrane ◽  
Central Regions ◽  
Descemet’S Membrane ◽  
Mechanical Manipulation

Corneal injury resulting from glaucoma surgery has been well described. Causes of injury can range from direct mechanical manipulation to the often more subtle pharmacologically induced injuries that occur with use of antifibrotic medications. Descemet’s membrane detachment (DMD) occurs uncommonly during or after intraocular surgery and has been linked with a variety of procedures ranging from simple clear cornea cataract extraction to deep lamellar keratoplasty. The corneal endothelium, which rests upon Descemet’s membrane, functions as a pump to keep the stroma from becoming swollen. Therefore, DMD results in focal corneal edema and possibly bullous keratopathy. If detachment of Descemet’s membrane extends far enough centrally, visual acuity may become sufficiently compromised to necessitate corneal transplantation surgery (either full-thickness penetrating keratoplasty [PKP] or Descemet’s stripping with automated endothelial keratoplasty [DSAEK]). In glaucoma surgery, DMD often results from the mechanical manipulation that occurs with creation of the cornealtrabecular meshwork opening. Knowing how to accurately diagnose and treat DMD can prevent disastrous consequences and preserve vision. Mackool and Holtz proposed separating DMD into 2 categories, planar and nonplanar, depending on the distance of separation between Descemet’s membrane and the posterior corneal stroma. Planar DMD involves less than 1 mm separation of Descemet’s membrane from the corneal stroma and may be limited to the periphery or extend from the periphery to central regions. Nonplanar DMD involves greater than 1 mm separation of Descemet’s membrane from the corneal stroma and may also be categorized as limited to the periphery or extending to central regions. The significance of this classification was the belief that planar DMD was more likely to spontaneously resolve while nonplanar DMD required surgical intervention. Assia and colleagues also split DMD into 2 categories: DMD with scrolling of tissue and DMD without scrolling of tissue. They believed this classification more accurately described potential for spontaneous resolution in that nonscrolled DMD was more likely to resolve without surgical intervention, even if its location was >1mm from the posterior corneal stroma. While useful as a general guide, these classification systems are not foolproof, and each case of DMD should be viewed independently.

scholarly journals A simple DNA handle attachment method for single molecule mechanical manipulation experiments

2016 ◽  
Vol 25 (8) ◽  
pp. 1535-1544 ◽  
Author(s):  
Duyoung Min ◽  
Mark A. Arbing ◽  
Robert E. Jefferson ◽  
James U. Bowie
Keyword(s):  
Single Molecule ◽  
Mechanical Manipulation

scholarly journals Effects of a ETA receptor antagonist, BQ-123, on renal vasoconstriction induced by mechanical manipulation to renal artery

1995 ◽  
Vol 67 ◽  
pp. 319
Author(s):  
Yoshihiko Watarai ◽  
Mitsuhiro Yoshioka ◽  
Katsutoshi Tanda ◽  
Toshimori Seki ◽  
Hideya Saito ◽  
...  
Keyword(s):  
Renal Artery ◽  
Receptor Antagonist ◽  
Renal Vasoconstriction ◽  
Eta Receptor ◽  
Mechanical Manipulation ◽  
Eta Receptor Antagonist

Drawing in poly(ε-caprolactone) fibers: tuning mechanics, fiber dimensions and surface-modification density

2017 ◽  
Vol 5 (23) ◽  
pp. 4499-4506 ◽  
Author(s):  
Si-Eun Kim ◽  
Alex M. Jordan ◽  
LaShanda T. J. Korley ◽  
Jonathan K. Pokorski
Keyword(s):  
Surface Modification ◽  
Complex Interplay ◽  
Photochemical Yield ◽  
Fiber Dimensions ◽  
Mechanical Manipulation

This work describes the complex interplay between mechanical manipulation of coextruded fibers and the resulting photochemical yield of surface modification.

Perspectives for the mechanical manipulation of hybrid hydrogels

2011 ◽  
Vol 2 (1) ◽  
pp. 18-32 ◽  
Author(s):  
Renate Messing ◽  
Annette M. Schmidt
Keyword(s):  
Hybrid Hydrogels ◽  
Mechanical Manipulation
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