Creating a microcircuit of the striatum using connectivity, morphological and electrophysiological data

2021 ◽  
Author(s):  
Alexander Kozlov
Keyword(s):  
Electrophysiological Data

scholarly journals The neurophysiological lesson from the Italian CIDP database

2021 ◽  
Author(s):  
Emanuele Spina ◽  
◽  
Pietro Emiliano Doneddu ◽  
Giuseppe Liberatore ◽  
Dario Cocito ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Odds Ratio ◽  
Motor Nerve ◽  
Lower Number ◽  
Chronic Inflammatory Demyelinating Polyradiculoneuropathy ◽  
Curve Analysis ◽  
Roc Curve Analysis ◽  
Electrophysiological Data ◽  
Electrophysiological Examination ◽  
Temporal Dispersion

Abstract Introduction Electrophysiological diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) may be challenging. Thus, with the aim ofproviding some practical advice in electrophysiological approach to a patient with suspected CIDP, we analyzed electrophysiological data from 499 patients enrolled inthe Italian CIDP Database. Methods We calculated the rate of each demyelinating feature, the rate of demyelinating features per nerve, the diagnostic rate for upper andlower limb nerves, and, using a ROC curve analysis, the diagnostic accuracy of each couple of nerves and each demyelinating feature, for every CIDP subtype.Moreover, we compared the electrophysiological data of definite and probable CIDP patients with those of possible and not-fulfilling CIDP patients, and by a logisticregression analysis, we estimated the odds ratio (OR) to make an electrophysiological diagnosis of definite or probable CIDP. Results The ulnar nerve had the highestrate of demyelinating features and, when tested bilaterally, had the highest diagnostic accuracy except for DADS in which peroneal nerves were the most informative.In possible and not-fulfilling CIDP patients, a lower number of nerves and proximal temporal dispersion (TD) measurements had been performed compared to definiteand probable CIDP patients. Importantly, OR for each tested motor nerve and each TD measurement was 1.59 and 1.33, respectively. Conclusion Our findingsdemonstrated that the diagnosis of CIDP may be missed due to inadequate or incomplete electrophysiological examination or interpretation. At the same time, thesedata taken together could be useful to draw a thoughtful electrophysiological approach to patients suspected of CIDP.

Reproducibility and efficiency in handling complex neurophysiological data

Neuroforum ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Michael Denker ◽  
Sonja Grün ◽  
Thomas Wachtler ◽  
Hansjörg Scherberger
Keyword(s):  
Best Practices ◽  
Data Management ◽  
Data Integrity ◽  
Behavioral Neuroscience ◽  
Data Set ◽  
Data Publication ◽  
Electrophysiological Data ◽  
Data Formats ◽  
Neurophysiological Data ◽  
Community Effort

Abstract Preparing a neurophysiological data set with the aim of sharing and publishing is hard. Many of the available tools and services to provide a smooth workflow for data publication are still in their maturing stages and not well integrated. Also, best practices and concrete examples of how to create a rigorous and complete package of an electrophysiology experiment are still lacking. Given the heterogeneity of the field, such unifying guidelines and processes can only be formulated together as a community effort. One of the goals of the NFDI-Neuro consortium initiative is to build such a community for systems and behavioral neuroscience. NFDI-Neuro aims to address the needs of the community to make data management easier and to tackle these challenges in collaboration with various international initiatives (e.g., INCF, EBRAINS). This will give scientists the opportunity to spend more time analyzing the wealth of electrophysiological data they leverage, rather than dealing with data formats and data integrity.

Electrophysiological and Psychophysical Responses to Modulation of Contrast of a Grating Pattern

Perception ◽  
1972 ◽  
Vol 1 (3) ◽  
pp. 341-349 ◽  
Author(s):  
I Bodis-Wollner ◽  
C D Hendley ◽  
J J Kulikowski
Keyword(s):  
Visual System ◽  
Human Visual System ◽  
Just Noticeable Difference ◽  
Evoked Responses ◽  
Successive Presentation ◽  
Electrophysiological Data ◽  
Grating Pattern ◽  
Modulation Rate ◽  
Contrast Discrimination ◽  
Lower Contrast

Contrast-modulated grating patterns were used to compare evoked responses and psychophysical thresholds of contrast modulation. The stimulus consisted of the successive presentation of a grating pattern at a higher and lower contrast. At a modulation rate of 8 Hz it was found that there is correspondence between the two kinds of data for a 6 cycle/degree grating. The just noticeable difference was not constant, and data approximated a Weber's law of contrast discrimination. However, it was found that there is a slight departure from this law, in that the ratio decreases with mean contrast. Both psychophysical and electrophysiological data exclude a model of simple luminance detection and are consistent with the operation of spatial contrast detectors in the human visual system.

scholarly journals Functional subgroups of rat and human sensory neurons: a systematic review of electrophysiological properties

2022 ◽  
Author(s):  
Jannis Körner ◽  
Angelika Lampert
Keyword(s):  
Systematic Review ◽  
Action Potential ◽  
Sensory Neurons ◽  
Input Resistance ◽  
Immune Reactivity ◽  
Electrophysiological Properties ◽  
Electrophysiological Data ◽  
Electrophysiological Studies ◽  
Dorsal Root Ganglia Neurons ◽  
Definition Of

AbstractSensory neurons are responsible for the generation and transmission of nociceptive signals from the periphery to the central nervous system. They encompass a broadly heterogeneous population of highly specialized neurons. The understanding of the molecular choreography of individual subpopulations is essential to understand physiological and pathological pain states. Recently, it became evident that species differences limit transferability of research findings between human and rodents in pain research. Thus, it is necessary to systematically compare and categorize the electrophysiological data gained from human and rodent dorsal root ganglia neurons (DRGs). In this systematic review, we condense the available electrophysiological data defining subidentities in human and rat DRGs. A systematic search on PUBMED yielded 30 studies on rat and 3 studies on human sensory neurons. Defined outcome parameters included current clamp, voltage clamp, cell morphology, pharmacological readouts, and immune reactivity parameters. We compare evidence gathered for outcome markers to define subgroups, offer electrophysiological parameters for the definition of neuronal subtypes, and give a framework for the transferability of electrophysiological findings between species. A semiquantitative analysis revealed that for rat DRGs, there is an overarching consensus between studies that C-fiber linked sensory neurons display a lower action potential threshold, higher input resistance, a larger action potential overshoot, and a longer afterhyperpolarization duration compared to other sensory neurons. They are also more likely to display an infliction point in the falling phase of the action potential. This systematic review points out the need of more electrophysiological studies on human sensory neurons.

scholarly journals MEA Viewer: a High-performance Interactive Application for Visualizing Electrophysiological Data

2017 ◽  
Author(s):  
Daniel C. Bridges ◽  
Kenneth R. Tovar ◽  
Bian Wu ◽  
Paul K. Hansma ◽  
Kenneth S. Kosik
Keyword(s):  
Action Potentials ◽  
High Performance ◽  
Detection Threshold ◽  
Electrode Arrays ◽  
Electrophysiological Data ◽  
Signal Average ◽  
Research Areas ◽  
Raster Plot ◽  
Data Files ◽  
Interactive Application

AbstractMulti-electrode arrays (MEAs) have been used for many years to measure electrical activity in ensembles of many hundreds of neurons, and are used in research areas as diverse as neuronal connectivity and drug discovery. A high sampling frequency is required to adequately capture action potentials, also known as spikes, the primary electrical event associated with neuronal activity, and the resulting raw data files are large and difficult to visualize with traditional plotting tools. Many common approaches to deal with this issue, such as extracting spikes times and solely performing spike train analysis, significantly reduce data dimensionality. Unbiased data exploration benefits from the use of tools that minimize data transforms and such tools enable the development of heuristic perspective from data prior to any subsequent processing. Here we introduce MEA Viewer, a high-performance interactive application for the direct visualization of multi-channel electrophysiological data. MEA Viewer provides many high-performance visualizations of electrophysiological data, including an easily navigable overview of all recorded extracellular signals overlaid with spike timestamp data and an interactive raster plot. Beyond the fundamental data displays, MEA Viewer can signal average and spatially overlay the extent of action potential propagation within single neurons. This view extracts information below the spike detection threshold to directly visualize the propagation of action potentials across the plane of the MEA. This entirely new method of using MEAs opens up new and novel research applications for medium density arrays. MEA Viewer is licensed under the General Public License version 3, GPLv3, and is available at http://github.com/dbridges/mea-tools.

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