Designing effective therapeutic strategies with multi-wavelength photoacoustic imaging

2021 ◽  
Author(s):  
Srivalleesha Mallidi
Keyword(s):  
Photoacoustic Imaging ◽  
Therapeutic Strategies ◽  
Multi Wavelength

scholarly journals Light-Emitting-Diode-Based Multispectral Photoacoustic Computed Tomography System

Sensors ◽  
2019 ◽  
Vol 19 (22) ◽  
pp. 4861 ◽  
Author(s):  
Sumit Agrawal ◽  
Christopher Fadden ◽  
Ajay Dangi ◽  
Xinyi Yang ◽  
Hussain Albahrani ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Molecular Imaging ◽  
Photoacoustic Imaging ◽  
Light Emitting Diode ◽  
Low Cost ◽  
Tunable Laser ◽  
Cost Effective ◽  
Light Emitting ◽  
Multi Wavelength ◽  
Human Finger

Photoacoustic computed tomography (PACT) has been widely explored for non-ionizing functional and molecular imaging of humans and small animals. In order for light to penetrate deep inside tissue, a bulky and high-cost tunable laser is typically used. Light-emitting diodes (LEDs) have recently emerged as cost-effective and portable alternative illumination sources for photoacoustic imaging. In this study, we have developed a portable, low-cost, five-dimensional (x, y, z, t, λ ) PACT system using multi-wavelength LED excitation to enable similar functional and molecular imaging capabilities as standard tunable lasers. Four LED arrays and a linear ultrasound transducer detector array are housed in a hollow cylindrical geometry that rotates 360 degrees to allow multiple projections through the subject of interest placed inside the cylinder. The structural, functional, and molecular imaging capabilities of the LED–PACT system are validated using various tissue-mimicking phantom studies. The axial, lateral, and elevational resolutions of the system at 2.3 cm depth are estimated as 0.12 mm, 0.3 mm, and 2.1 mm, respectively. Spectrally unmixed photoacoustic contrasts from tubes filled with oxy- and deoxy-hemoglobin, indocyanine green, methylene blue, and melanin molecules demonstrate the multispectral molecular imaging capabilities of the system. Human-finger-mimicking phantoms made of a bone and blood tubes show structural and functional oxygen saturation imaging capabilities. Together, these results demonstrate the potential of the proposed LED-based, low-cost, portable PACT system for pre-clinical and clinical applications.

Hybrid multi-wavelength photoacoustic imaging

2018 ◽  
Author(s):  
Tingyang Duan ◽  
Hengrong Lan ◽  
Hongtao Zhong ◽  
Meng Zhou ◽  
Ruochong Zhang ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Multi Wavelength

Notice of Removal: Characterization of human carotid plaques using multi-wavelength photoacoustic imaging

2017 ◽  
Author(s):  
Mustafa Umit Arabul ◽  
Maarten Heres ◽  
Marcel Rutten ◽  
Marc van Sambeek ◽  
Frans van de Vosse ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Carotid Plaques ◽  
Multi Wavelength ◽  
Human Carotid

scholarly journals Reflection artifact identification in photoacoustic imaging using multi-wavelength excitation

2018 ◽  
Vol 9 (10) ◽  
pp. 4613 ◽  
Author(s):  
Ho Nhu Y. Nguyen ◽  
Altaf Hussain ◽  
Wiendelt Steenbergen
Keyword(s):  
Photoacoustic Imaging ◽  
Multi Wavelength ◽  
Artifact Identification

Low-Cost Multi-Wavelength Photoacoustic Imaging Based on Portable Continuous-Wave Laser Diode Module

2020 ◽  
Vol 14 (4) ◽  
pp. 738-745
Author(s):  
Hongtao Zhong ◽  
Daohuai Jiang ◽  
Hengrong Lan ◽  
Tingyang Duan ◽  
Feng Gao ◽  
...  
Keyword(s):  
Laser Diode ◽  
Continuous Wave ◽  
Photoacoustic Imaging ◽  
Low Cost ◽  
Continuous Wave Laser ◽  
Multi Wavelength ◽  
Wave Laser

Application of multi-wavelength technique for photoacoustic imaging to delineate tumor margins during maximum-safe resection of glioma: A preliminary simulation study

2019 ◽  
Vol 70 ◽  
pp. 242-246 ◽  
Author(s):  
Ebrahim Najafzadeh ◽  
Hossein Ghadiri ◽  
Maysam Alimohamadi ◽  
Parastoo Farnia ◽  
Mohammad Mehrmohammadi ◽  
...  
Keyword(s):  
Simulation Study ◽  
Photoacoustic Imaging ◽  
Tumor Margins ◽  
Multi Wavelength
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