Bessel acoustic lens for large volumetric photoacoustic microscopy

2021 ◽  
Author(s):  
Xianlin Song
Keyword(s):  
Photoacoustic Microscopy ◽  
Acoustic Lens

Acoustic lens with variable focal length for photoacoustic microscopy

2013 ◽  
Vol 114 (19) ◽  
pp. 194703 ◽  
Author(s):  
Chaolong Song ◽  
Lei Xi ◽  
Huabei Jiang
Keyword(s):  
Focal Length ◽  
Photoacoustic Microscopy ◽  
Acoustic Lens

Phononic-Crystal Acoustic Lens by Design for Energy-Transmission Devices

2012 ◽  
Vol 132 (5) ◽  
pp. 686-690
Author(s):  
Yusuke Kanno ◽  
Kenji Tsuruta ◽  
Kazuhiro Fujimori ◽  
Hideki Fukano ◽  
Shigeji Nogi
Keyword(s):  
Phononic Crystal ◽  
Energy Transmission ◽  
Acoustic Lens

scholarly journals Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Yanfeng Dai ◽  
Xiang Yu ◽  
Jianshuang Wei ◽  
Fanxin Zeng ◽  
Yiran Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Scavenger Receptor ◽  
Intradermal Injection ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Surgery ◽  
Photoacoustic Microscopy ◽  
Dual Targeting ◽  
Scavenger Receptor Class ◽  
Distinct Distribution

Abstract Detection of sentinel lymph nodes (SLNs) is critical to guide the treatment of breast cancer. However, distinguishing metastatic SLNs from normal and inflamed lymph nodes (LNs) during surgical resection remains a challenge. Here, we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle (5K-HA-HPPS) loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast cancer. The small sized (~40 nm) self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal injection. Compared with normal popliteal LNs (N-LN), there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs (T-MLN) and inflamed LNs (Inf-LN), respectively, 6 h after nanoparticle inoculation. More importantly, photoacoustic microscopy (PAM) of 5K-HA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and Inf-LN. Signals were mainly distributed at the centre of T-MLN but at the periphery of N-LN and Inf-LN. The ratio of PA intensity (R) at the centre of the LNs compared with that at the periphery was 5.93 ± 0.75 for T-MLNs of the 5K-HA-HPPS group, which was much higher than that for the Inf-LNs (R = 0.2 ± 0.07) and N-LNs (R = 0.45 ± 0.09). These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs, thus guiding the removal of SLNs during breast cancer surgery.

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