Epidermal layer recognition of optical coherence tomography skin images

2021 ◽  
Author(s):  
Chenming Yang ◽  
Zhongliang Li ◽  
Nan Nan ◽  
Yang Bu ◽  
Xiangzhao Wang
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Epidermal Layer

The Value of Optical Coherence Tomography in Determining Surgical Margins in Squamous Cell Carcinoma of the Vulva: A Single-Center Prospective Study

2015 ◽  
Vol 25 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Ronni Wessels ◽  
Marc van Beurden ◽  
Daniel M. de Bruin ◽  
Dirk J. Faber ◽  
Andrew D. Vincent ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Optical Coherence Tomography ◽  
Cell Carcinoma ◽  
Layer Thickness ◽  
Surgical Margins ◽  
Optical Coherence ◽  
Epidermal Layer ◽  
Malignant Tissue ◽  
Benign Tissue ◽  
Oct Imaging

BackgroundVulvar squamous cell carcinoma (VSCC) is treated with wide local excision. The challenge is to remove as much skin as necessary to prevent recurrence, but meanwhile preserve genital skin to diminish morbidity. Optical coherence tomography (OCT) is a noninvasive imaging tool that produces cross-sectional images. Optical coherence tomography could be helpful in determining appropriate surgical margins during excision of VSCC.ObjectiveThis study aimed to assess the value of OCT in determining appropriate surgical margins in patients operated for VSCC. We hypothesize that benign tissue will differ qualitatively (presence of clear epidermal layers) and quantitatively (epidermal layer thickness and attenuation coefficient) from (pre)malignant tissue.Materials and MethodsIn 18 patients with a pretreatment biopsy of VSCC, before excision, areas within the center (tumor), at the margin (skin next to the center), and in normal vulvar skin outside the area of resection were imaged by OCT. Optical coherence tomography data were assessed on the presence of a clear epidermal layer, thickness of the epidermal layer, and values of μOCT. Results were grouped according to histopathological report in a benign group and a (pre)malignant group.ResultsA clear epidermal layer was observed in all OCT images of benign tissue and only in 6 of 23 premalignant lesions (P < 0.001). The epidermal layer thickness as well as the μOCT was significantly smaller for benign vulvar tissue than for (pre)malignant tissue (0.29 vs 1.03 mm, and 2.4 vs 4.1 mm−1, respectively; P < 0.001). The diagnostic accuracy of OCT, as calculated by receiver operating characteristic curve analysis, showed at defined thresholds a sensitivity of 100% and specificity of 80% when considering layer thickness, and a sensitivity of 100% and specificity of 70% when considering the attenuation coefficient.ConclusionsWe show that qualitative and quantitative OCT imaging can distinguish between benign and (pre)malignant vulvar tissue, enabling appropriate surgical margin detection with noninvasive in vivo OCT imaging.

1086: Cystoscopic Optical Coherence Tomography in Diagnosis and Management of Clinical Bladder Tumors

2007 ◽  
Vol 177 (4S) ◽  
pp. 358-359 ◽  
Author(s):  
Christopher S. Lee ◽  
Alek Mishail ◽  
Jason M. Kim ◽  
Alexander Kirshenbaum ◽  
Howard L. Adler ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bladder Tumors ◽  
Diagnosis And Management

1227: Optical Coherence Tomography-Guided Surgery of Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 395-395
Author(s):  
Nancy J. Tresser ◽  
Elena V. Zagaynova ◽  
Olga S. Streltsova ◽  
Natalia D. Gladkova ◽  
Vladislav A. Kamensky ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Guided Surgery

258: Diagnosis and Intraoperative Staging of Bladder Disease by in-vivo Optical Coherence Tomography (OCT)

2004 ◽  
Vol 171 (4S) ◽  
pp. 68-68 ◽  
Author(s):  
Markus D. Sachs ◽  
Dmitry Daniltchenko ◽  
Eva Lankenau ◽  
Frank Koenig ◽  
Gerion Huettmann ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bladder Disease

Dental optical coherence tomography: a comparison of two in vitro systems

1999 ◽  
Vol 29 (2) ◽  
pp. 85-89 ◽  
Author(s):  
L L Otis ◽  
B W Colston ◽  
M J Everett ◽  
H Nathel
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
In Vitro Systems
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