A deblurring/denoising corrected scintigraphic planar image reconstruction model for targeted alpha therapy

2021 ◽  
Author(s):  
Charles Ross Schmidtlein ◽  
Matthew K. Maroun ◽  
Andrzej Krol ◽  
Howard Gifford ◽  
Lisa Bodei ◽  
...  
Keyword(s):  
Image Reconstruction ◽  
Targeted Alpha Therapy ◽  
Planar Image ◽  
Alpha Therapy ◽  
Reconstruction Model

Nanoconstructs in Targeted Alpha-Therapy

2015 ◽  
Vol 4 (2) ◽  
pp. 71-76 ◽  
Author(s):  
Jan Kozempel ◽  
Martin Vlk
Keyword(s):  
Targeted Alpha Therapy ◽  
Alpha Therapy

scholarly journals Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)

2021 ◽  
Author(s):  
Tadashi Watabe ◽  
Makoto Hosono ◽  
Seigo Kinuya ◽  
Takahiro Yamada ◽  
Sachiko Yanagida ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Japanese Society ◽  
Radiation Safety ◽  
Safety Management ◽  
Evaluation Methodology ◽  
Targeted Alpha Therapy ◽  
Safety Issues ◽  
Safety Standards ◽  
And Training ◽  
Alpha Therapy

AbstractWe present the guideline for use of [211At] sodium astatide (NaAt) for targeted alpha therapy in clinical trials on the basis of radiation safety issues in Japan. This guideline was prepared by a study supported by the Ministry of Health, Labour, and Welfare, and approved by the Japanese Society of Nuclear Medicine on 8th Feb, 2021. The study showed that patients receiving [211At]NaAt do not need to be admitted to a radiotherapy room and outpatient treatment is possible. The radiation exposure from the patient is within the safety standards of the ICRP and IAEA recommendations for the general public and caregivers. Precautions for patients and their families, safety management associated with the use of [211At]NaAt, education and training, and disposal of medical radioactive contaminants are also included in this guideline. Treatment using [211At]NaAt in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection and evaluation methodology shown here are considered internationally useful as well.

scholarly journals Evaluation of Actinium-225 radiolabeled cyclized alpha-melanocyte stimulating hormone (CycMSH) peptide for targeted alpha therapy

2021 ◽  
Vol 96-97 ◽  
pp. S101
Author(s):  
Victoria Brown ◽  
Cristina Rodríguez-Rodríguez ◽  
Chengcheng Zhang ◽  
Keiran Maskell ◽  
Francois Benard ◽  
...  
Keyword(s):  
Targeted Alpha Therapy ◽  
Melanocyte Stimulating Hormone ◽  
Alpha Therapy ◽  
Stimulating Hormone

scholarly journals Extended single-dose toxicity study of [211At]NaAt in mice for the first-in-human clinical trial of targeted alpha therapy for differentiated thyroid cancer

2021 ◽  
Author(s):  
Tadashi Watabe ◽  
Kazuko Kaneda-Nakashima ◽  
Kazuhiro Ooe ◽  
Yuwei Liu ◽  
Kenta Kurimoto ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Body Weight ◽  
Thyroid Cancer ◽  
Single Dose ◽  
General Condition ◽  
Blood Test ◽  
Differentiated Thyroid Cancer ◽  
Targeted Alpha Therapy ◽  
Evaluation Point ◽  
Alpha Therapy

Abstract Objective Astatine (211At) is a promising alpha emitter as an alternative to iodine (131I). We are preparing the first-in-human (FIH) clinical trial of targeted alpha therapy for differentiated thyroid cancer in consultation with Pharmaceuticals and Medical Devices Agency. Here, we performed an extended single-dose toxicity examination under a reliability standard, as a preclinical safety assessment of [211At]NaAt to determine the FIH dose. Methods [211At]NaAt solution was injected into normal 6-week-old mice (male (n = 50) and female (n = 50), body weight: male 33.2 ± 1.7 g, female 27.3 ± 1.5 g), which were then divided into four groups: 5 MBq/kg (n = 20), 20 MBq/kg (n = 20), 50 MBq/kg (n = 30), saline control (n = 30). The mice were followed up for 5 days (primary evaluation point for acute toxicity: n = 80) or 14 days (n = 20: evaluation point for recovery) to monitor general condition and body weight change. At the end of the observation period, necropsy, blood test, organ weight measurement, and histopathological examination were performed. For body weight, blood test, and organ weight, statistical analyses were performed to compare data between the control and injected groups. Results No abnormal findings were observed in the general condition of mice. In the 50 MBq/kg group, males (days 3 and 5) showed a significant decrease in body weight compared with the control. However, necropsy did not differ significantly beyond the range of spontaneous lesions. In the blood test, males (50 MBq/kg) and females (50 MBq/kg) showed a decrease in white blood cell and platelet counts on day 5, and recovery on day 14. In the testis, a considerable weight decrease was observed on day 14 (50 MBq/kg), and multinucleated giant cells were observed in all mice, indicating a significant change related to the administration of [211At]NaAt. Conclusions In the extended single-dose toxicity study of [211At]NaAt, administration of high doses resulted in weight loss, transient bone marrow suppression, and pathological changes in the testis, which require consideration in the FIH clinical trial.

scholarly journals Gold nanoparticle bioconjugates labelled with 211At for targeted alpha therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (65) ◽  
pp. 41024-41032 ◽  
Author(s):  
L. Dziawer ◽  
P. Koźmiński ◽  
S. Męczyńska-Wielgosz ◽  
M. Pruszyński ◽  
M. Łyczko ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Radionuclide Therapy ◽  
Targeted Alpha Therapy ◽  
Alpha Therapy

Gold nanoparticles labeled with 211At are very effective in radionuclide therapy.

scholarly journals Combining Bismuth-213 with Nanobodies: Finding the Perfect Match for Targeted Alpha Therapy

2019 ◽  
Vol 50 (1) ◽  
pp. S7-S8
Author(s):  
Yana Dekempeneer ◽  
Vicky Caveliers ◽  
Matthias D’huyvetter ◽  
Dominic Maertens ◽  
Mireille Gysemans ◽  
...  
Keyword(s):  
Perfect Match ◽  
Targeted Alpha Therapy ◽  
Alpha Therapy

scholarly journals Production and supply of alpha particles emitting radionuclides for Targeted Alpha Therapy (TAT).

2021 ◽  
pp. jnumed.120.261016
Author(s):  
Valery Radchenko ◽  
Alfred Morgenstern ◽  
Amirreza Jalilian ◽  
Caterina Ramogida ◽  
Cathy S Cutler ◽  
...  
Keyword(s):  
Alpha Particles ◽  
Targeted Alpha Therapy ◽  
Alpha Therapy

Targeted alpha therapy using Radium-223: From physics to biological effects

2018 ◽  
Vol 68 ◽  
pp. 47-54 ◽  
Author(s):  
I.A. Marques ◽  
A.R. Neves ◽  
A.M. Abrantes ◽  
A.S. Pires ◽  
E. Tavares-da-Silva ◽  
...  
Keyword(s):  
Biological Effects ◽  
Targeted Alpha Therapy ◽  
Radium 223 ◽  
Alpha Therapy
Sign in / Sign up

Export Citation Format

Share Document