New generation of miniaturized, high-mass-sensitivity quartz crystal microbalances (QCMs) for space applications

Author(s):  
Donald A. Wallace ◽  
Scott A. Wallace
2019 ◽  
Vol 287 ◽  
pp. 48-75 ◽  
Author(s):  
Fabrizio Dirri ◽  
Ernesto Palomba ◽  
Andrea Longobardo ◽  
Emiliano Zampetti ◽  
Bortolino Saggin ◽  
...  

Sensors ◽  
2019 ◽  
Vol 19 (18) ◽  
pp. 3968 ◽  
Author(s):  
Xianhe Huang ◽  
Qiao Chen ◽  
Wei Pan ◽  
Jianguo Hu ◽  
Yao Yao

Mass sensitivity is vital for quartz crystal microbalance (QCM)-based data analysis. The mass sensitivity distribution of QCMs may differ greatly depending on the shapes, thicknesses, sizes, and materials of the metal electrodes. This is not considered by the Sauerbrey equation, and has a large potential to cause errors in QCM-based data analysis. Many previous works have studied the effects of shape, thickness, and size of metal electrodes on mass sensitivity. However, it is necessary to continue to clarify the relationship between the mass sensitivity and the electrode material of the QCM. In this paper, the results of both theoretical calculation and experimental analysis showed that the mass sensitivity of QCMs with gold electrodes is higher than that of the QCMs with silver electrodes, which in turn indicated that the mass sensitivity of QCMs varies with the electrode material. Meanwhile, the results of this study showed that the mass sensitivity of QCMs with different electrode materials is not proportional to the density of the electrode materials. This result suggests that, in order to obtain more accurate results in the practical applications of QCMs, the influence of electrode material on the mass sensitivity of the QCMs must be considered.


2009 ◽  
Vol 135 (2) ◽  
pp. 444-448 ◽  
Author(s):  
Dongkyu Lee ◽  
Myungsun Yoo ◽  
Hyejung Seo ◽  
Youngjo Tak ◽  
Wan-Gee Kim ◽  
...  

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Yaobo Ding ◽  
Patrick Weindl ◽  
Anke-Gabriele Lenz ◽  
Paula Mayer ◽  
Tobias Krebs ◽  
...  

Abstract Background Accurate knowledge of cell−/tissue-delivered dose plays a pivotal role in inhalation toxicology studies, since it is the key parameter for hazard assessment and translation of in vitro to in vivo dose-response. Traditionally, (nano-)particle toxicological studies with in vivo and in vitro models of the lung rely on in silio computational or off-line analytical methods for dosimetry. In contrast to traditional in vitro testing under submerged cell culture conditions, the more physiologic air-liquid interface (ALI) conditions offer the possibility for real-time dosimetry using quartz crystal microbalances (QCMs). However, it is unclear, if QCMs are sensitive enough for nanotoxicological studies. We investigated this issue for two commercially available VITROCELL®Cloud ALI exposure systems. Results Quantitative fluorescence spectroscopy of fluorescein-spiked saline aerosol was used to determine detection limit, precision and accuracy of the QCMs implemented in a VITROCELL®Cloud 6 and Cloud 12 system for dose-controlled ALI aerosol-cell exposure experiments. Both QCMs performed linearly over the entire investigated dose range (200 to 12,000 ng/cm2) with an accuracy of 3.4% (Cloud 6) and 3.8% (Cloud 12). Their precision (repeatability) decreased from 2.5% for large doses (> 9500 ng/cm2) to values of 10% and even 25% for doses of 1000 ng/cm2 and 200 ng/cm2, respectively. Their lower detection limit was 170 ng/cm2 and 169 ng/cm2 for the Cloud 6 and Cloud 12, respectively. Dose-response measurements with (NM110) ZnO nanoparticles revealed an onset dose of 3.3 μg/cm2 (or 0.39 cm2/cm2) for both cell viability (WST-1) and cytotoxicity (LDH) of A549 lung epithelial cells. Conclusions The QCMs of the Cloud 6 and Cloud 12 systems show similar performance and are highly sensitive, accurate devices for (quasi-) real-time dosimetry of the cell-delivered particle dose in ALI cell exposure experiments, if operated according to manufacturer specifications. Comparison with in vitro onset doses from this and previously published ALI studies revealed that the detection limit of 170 ng/cm2 is sufficient for determination of toxicological onset doses for all particle types with low (e.g. polystyrene) or high mass-specific toxicity (e.g. ZnO and Ag) investigated here. Hence, in principle QCMs are suitable for in vitro nanotoxciological studies, but this should be investigated for each QCM and ALI exposure system under the specific exposure conditions as described in the present study.


Sensors ◽  
2019 ◽  
Vol 19 (9) ◽  
pp. 2125 ◽  
Author(s):  
Qiao Chen ◽  
Xianhe Huang ◽  
Wei Pan ◽  
Yuan Xu ◽  
Zhichao Fan

Mass sensitivity plays a crucial role in the practical application of quartz crystal microbalances (QCMs)-based quantitative analysis. n-m type QCMs have many applications, so it is necessary to clarify the relationship between the mass sensitivity and the electrode of the n-m type QCM. The performance of gold-plated films with different electrodes was studied by theoretical calculation and experiment. The results show that the mass sensitivity on the surface of the n electrode and the surface of the m electrode are essentially the same. Meanwhile, the mass sensitivity of n-m type QCMs varies with the diameter of the n and m electrodes. When the diameter of the n electrode is close to half the diameter of the m electrode, mass sensitivity is at maximum value. These results are important for the further designs and applications of n-m type QCMs.


2017 ◽  
Vol 13 (S336) ◽  
pp. 201-206 ◽  
Author(s):  
Luca Moscadelli ◽  
Alberto Sanna ◽  
Ciriaco Goddi

AbstractImaging the inner few 1000 AU around massive forming stars, at typical distances of several kpc, requires angular resolutions of better than 0″.1. Very Long Baseline Interferometry (VLBI) observations of interstellar molecular masers probe scales as small as a few AU, whereas (new-generation) centimeter and millimeter interferometers allow us to map scales of the order of a few 100 AU. Combining these informations all together, it presently provides the most powerful technique to trace the complex gas motions in the proto-stellar environment. In this work, we review a few compelling examples of this technique and summarize our findings.


2020 ◽  
Vol 3 (6) ◽  
pp. 5687-5697 ◽  
Author(s):  
Roto Roto ◽  
Aditya Rianjanu ◽  
Annisa Rahmawati ◽  
Innas Amaliya Fatyadi ◽  
Nursidik Yulianto ◽  
...  

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