MRI-compatible mechatronic needle guidance system for focal thermal laser ablation in localized prostate cancer

2021 ◽  
Author(s):  
Eric Knull ◽  
Claire K. Park ◽  
Jeffrey Bax ◽  
David Tessier ◽  
Aaron Fenster
Keyword(s):  
Prostate Cancer ◽  
Laser Ablation ◽  
Guidance System ◽  
Localized Prostate Cancer ◽  
Needle Guidance

Magnetic resonance image‐guided focal laser ablation in clinically localized prostate cancer: safety and efficacy

2019 ◽  
Vol 89 (12) ◽  
pp. 1610-1614 ◽  
Author(s):  
Yasser Al‐Hakeem ◽  
Orit Raz ◽  
Zita Gacs ◽  
Fiona Maclean ◽  
Celi Varol
Keyword(s):  
Prostate Cancer ◽  
Laser Ablation ◽  
Magnetic Resonance ◽  
Magnetic Resonance Image ◽  
Localized Prostate Cancer ◽  
Safety And Efficacy ◽  
Image Guided

Two-year Outcomes Following Focal Laser Ablation of Localized Prostate Cancer

2018 ◽  
Vol 1 (2) ◽  
pp. 129-133 ◽  
Author(s):  
Brian Chao ◽  
Elton Llukani ◽  
Herbert Lepor
Keyword(s):  
Prostate Cancer ◽  
Laser Ablation ◽  
Localized Prostate Cancer

MRI-guided prostate focal laser ablation therapy using a mechatronic needle guidance system

2014 ◽  
Author(s):  
Jeremy Cepek ◽  
Uri Lindner ◽  
Sangeet Ghai ◽  
Sean R. H. Davidson ◽  
John Trachtenberg ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Guidance System ◽  
Needle Guidance ◽  
Ablation Therapy ◽  
Mri Guided

scholarly journals Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

2019 ◽  
Vol 116 (37) ◽  
pp. 18590-18596 ◽  
Author(s):  
Ardeshir R. Rastinehad ◽  
Harry Anastos ◽  
Ethan Wajswol ◽  
Jared S. Winoker ◽  
John P. Sfakianos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Laser Ablation ◽  
Near Infrared ◽  
Safety Data ◽  
Treatment Protocol ◽  
Fusion Imaging ◽  
Localized Prostate Cancer ◽  
Infrared Light ◽  
Intermediate Risk ◽  
Significant Difference

Biocompatible gold nanoparticles designed to absorb light at wavelengths of high tissue transparency have been of particular interest for biomedical applications. The ability of such nanoparticles to convert absorbed near-infrared light to heat and induce highly localized hyperthermia has been shown to be highly effective for photothermal cancer therapy, resulting in cell death and tumor remission in a multitude of preclinical animal models. Here we report the initial results of a clinical trial in which laser-excited gold-silica nanoshells (GSNs) were used in combination with magnetic resonance–ultrasound fusion imaging to focally ablate low-intermediate-grade tumors within the prostate. The overall goal is to provide highly localized regional control of prostate cancer that also results in greatly reduced patient morbidity and improved functional outcomes. This pilot device study reports feasibility and safety data from 16 cases of patients diagnosed with low- or intermediate-risk localized prostate cancer. After GSN infusion and high-precision laser ablation, patients underwent multiparametric MRI of the prostate at 48 to 72 h, followed by postprocedure mpMRI/ultrasound targeted fusion biopsies at 3 and 12 mo, as well as a standard 12-core systematic biopsy at 12 mo. GSN-mediated focal laser ablation was successfully achieved in 94% (15/16) of patients, with no significant difference in International Prostate Symptom Score or Sexual Health Inventory for Men observed after treatment. This treatment protocol appears to be feasible and safe in men with low- or intermediate-risk localized prostate cancer without serious complications or deleterious changes in genitourinary function.

Focal Laser Ablation for Localized Prostate Cancer

2010 ◽  
Vol 24 (5) ◽  
pp. 791-797 ◽  
Author(s):  
Uri Lindner ◽  
Nathan Lawrentschuk ◽  
John Trachtenberg
Keyword(s):  
Prostate Cancer ◽  
Laser Ablation ◽  
Localized Prostate Cancer
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