Novel flexible membrane based SERS for biomarker detection in chronic wound healing

2021 ◽  
Author(s):  
Jayakumar Perumal ◽  
Dinish U.S. ◽  
Hann Qian Lim ◽  
Amalina B. Attia ◽  
David I. Leavesley ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Biomarker Detection ◽  
Flexible Membrane

scholarly journals Novel Cellulose Fibre-Based Flexible Plasmonic Membrane for Point-of-Care SERS Biomarker Detection in Chronic Wound Healing

2021 ◽  
Vol Volume 16 ◽  
pp. 5869-5878
Author(s):  
Jayakumar Perumal ◽  
Hann Qian Lim ◽  
Amalina Binte Ebrahim Attia ◽  
Riazul Raziq ◽  
David Ian Leavesley ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Point Of Care ◽  
Cellulose Fibre ◽  
Biomarker Detection

scholarly journals Polylactic acid-based electrospun fiber and hyaluronic acid-valsartan hydrogel scaffold for chronic wound healing

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Margaret O. Ilomuanya ◽  
Prosper S. Okafor ◽  
Joyce N. Amajuoyi ◽  
John C. Onyejekwe ◽  
Omotunde O. Okubanjo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Polylactic Acid ◽  
Chronic Wound ◽  
Electrospun Fiber ◽  
Hydrogel Scaffold

scholarly journals Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 349
Author(s):  
Anam Razzaq ◽  
Zaheer Ullah Khan ◽  
Aasim Saeed ◽  
Kiramat Ali Shah ◽  
Naveed Ullah Khan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polyvinyl Alcohol ◽  
Mtt Assay ◽  
Chronic Wound ◽  
Drug Loading ◽  
Group Identification ◽  
Wound Infections ◽  
Diabetic Wound

Diabetic wound infections caused by conventional antibiotic-resistant Staphylococcus aureus strains are fast emerging, leading to life-threatening situations (e.g., high costs, morbidity, and mortality) associated with delayed healing and chronic inflammation. Electrospinning is one of the most widely used techniques for the fabrication of nanofibers (NFs), induced by a high voltage applied to a drug-loaded polymer solution. Particular attention is given to electrospun NFs for pharmaceutical applications (e.g., original drug delivery systems) and tissue regeneration (e.g., as tissue scaffolds). However, there is a paucity of reports related to their application in diabetic wound infections. Therefore, we prepared eco-friendly, biodegradable, low-immunogenic, and biocompatible gelatin (GEL)/polyvinyl alcohol (PVA) electrospun NFs (BNFs), in which we loaded the broad-spectrum antibiotic cephradine (Ceph). The resulting drug-loaded NFs (LNFs) were characterized physically using ultraviolet-visible (UV-Vis) spectrophotometry (for drug loading capacity (LC), drug encapsulation efficiency (EE), and drug release kinetics determination), thermogravimetric analysis (TGA) (for thermostability evaluation), scanning electron microscopy (SEM) (for surface morphology analysis), and Fourier-transform infrared spectroscopy (FTIR) (for functional group identification). LNFs were further characterized biologically by in-vitro assessment of their potency against S. aureus clinical strains (N = 16) using the Kirby–Bauer test and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, by ex-vivo assessment to evaluate their cytotoxicity against primary human epidermal keratinocytes using MTT assay, and by in-vivo assessment to estimate their diabetic chronic wound-healing efficiency using NcZ10 diabetic/obese mice (N = 18). Thin and uniform NFs with a smooth surface and standard size (<400 nm) were observed by SEM at the optimized 5:5 (GEL:PVA) volumetric ratio. FTIR analyses confirmed the drug loading into BNFs. Compared to free Ceph, LNFs were significantly more thermostable and exhibited sustained/controlled Ceph release. LNFs also exerted a significantly stronger antibacterial activity both in-vitro and in-vivo. LNFs were significantly safer and more efficient for bacterial clearance-induced faster chronic wound healing. LNF-based therapy could be employed as a valuable dressing material to heal S. aureus-induced chronic wounds in diabetic subjects.

scholarly journals Chronic Wound Healing: A Review of Current Management and Treatments

2017 ◽  
Vol 34 (3) ◽  
pp. 599-610 ◽  
Author(s):  
George Han ◽  
Roger Ceilley
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Current Management

Human-microorganism mutualism theory: Possible mechanisms for the delayed chronic wound healing process

2020 ◽  
Vol 141 ◽  
pp. 109720
Author(s):  
Mengru Pang ◽  
Zexin Yao ◽  
Caihong Chen ◽  
Xiaoxuan Lei ◽  
Biao Cheng
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Healing Process ◽  
Wound Healing Process

scholarly journals Wounds: an overlooked burden (Part 1) – effective wound management starts with proper wound assessment

2020 ◽  
pp. 196-198
Author(s):  
H Parkar ◽  
AD Cromarty
Keyword(s):  
Wound Healing ◽  
General Practice ◽  
Healthcare Professionals ◽  
Chronic Wound ◽  
Treatment Strategies ◽  
Daily Basis ◽  
Wound Management ◽  
Wound Treatment ◽  
Wound Assessment ◽  
Wound Type

Healthcare professionals in general practice are tasked with treatment and management of wounds on a daily basis. The prognoses of these wounds are directly affected by the ability of the clinician to assess these wounds according to several parameters, including the wound type and the features which determine whether a wound is acute or transforming to a chronic wound. This can be achieved by proper and continuous wound assessment, which should guide wound treatment strategies to ensure optimal wound healing and prevent progression to complicated wounds.

Skin substitutes for acute and chronic wound healing: an updated review

2020 ◽  
Vol 31 (6) ◽  
pp. 639-648 ◽  
Author(s):  
Christina Dai ◽  
Shawn Shih ◽  
Amor Khachemoune
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Skin Substitutes
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