Raman needle probe for compositional and structural analysis of articular cartilage during early osteoarthritis

2021 ◽  
Author(s):  
Magnus Jensen ◽  
Conor Horgan ◽  
Juncheng Zhang ◽  
Man I. Wu ◽  
Tom Vercauteren ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Structural Analysis ◽  
Early Osteoarthritis ◽  
Needle Probe

Multiplexed polarized hypodermic Raman needle probe for biostructural analysis of articular cartilage

2020 ◽  
Vol 45 (10) ◽  
pp. 2890
Author(s):  
Magnus Jensen ◽  
Conor C. Horgan ◽  
Tom Vercauteren ◽  
Michael B. Albro ◽  
Mads S. Bergholt
Keyword(s):  
Articular Cartilage ◽  
Needle Probe

A NIR-II fluorescent probe for articular cartilage degeneration imaging and osteoarthritis detection

2019 ◽  
Vol 7 (3) ◽  
pp. 1043-1051 ◽  
Author(s):  
Wanrong Yi ◽  
Hui Zhou ◽  
Anguo Li ◽  
Ying Yuan ◽  
Yaqi Guo ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Fluorescent Probe ◽  
Type Ii Collagen ◽  
Cartilage Degeneration ◽  
Type Ii ◽  
Early Osteoarthritis ◽  
Collagen Binding ◽  
Binding Peptide ◽  
Articular Cartilage Degeneration

A Type II collagen-binding peptide based NIR-II fluorescent probe for articular cartilage degeneration imaging and early osteoarthritis detection.

Multiple Platelet-Rich Plasma Injections Versus Single Platelet-Rich Plasma Injection in Early Osteoarthritis of the Knee: An Experimental Study in a Guinea Pig Model of Early Knee Osteoarthritis

2019 ◽  
Vol 47 (10) ◽  
pp. 2300-2307 ◽  
Author(s):  
Devendra K. Chouhan ◽  
Mandeep S. Dhillon ◽  
Sandeep Patel ◽  
Tungish Bansal ◽  
Alka Bhatia ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Single Injection ◽  
Platelet Rich Plasma ◽  
Early Osteoarthritis ◽  
Short Term ◽  
Multiple Injections ◽  
The Mean ◽  
Guinea Pig Model ◽  
Better Than

Background:Platelet-rich plasma (PRP) has emerged as the forerunner among disease-modifying treatment options for early osteoarthritis (OA) of the knee. However, no consensus is available regarding optimum dosing schedules.Purpose:To determine whether multiple injections of PRP (3 injections) provide better short-term and long-term results than a single injection of PRP in a guinea pig model of knee OA.Study Design:Controlled laboratory study.Methods:36 Dunkin-Hartley guinea pigs (weighing ~600-800 g) were chosen for this study. The animals were assigned to group DC (disease control group), group G1 (single-PRP group), and group G2 (multiple-PRP group) containing 10, 10, and 12 animals, respectively. Another 4 animals were used for preparation of allogenic PRP. Groups G1 and G2 received 1 and 3 injections of PRP, respectively, at weekly intervals in the intervention knee while the contralateral knee was injected with normal saline. Group DC received no intervention in either knee. Half of the animals from each group (subgroups DC.3, G1.3, and G2.3) were sacrificed at 3 months, and the remaining half (subgroups DC.6, G1.6, and G2.6) were sacrificed at 6 months after intervention. Both knee joints were harvested for histological assessment of articular cartilage and synovium.Results:The mean synovial scores for groups G1 and G2 were significantly better than those for group DC at 3 months. No difference was found between groups G1 and G2 at 3 months. At 6 months, group G2 had significantly better mean synovial scores than group G1 and group DC. The mean articular cartilage scores in group G2 were significantly better than those in group DC at 3 months. However, at 6 months, no significant difference was found among any of the groups in terms of mean articular scores.Conclusion:Both single and multiple injections of PRP exert similar anti-inflammatory effects on the synovium in the short term. However, this effect is sustained in the long term only for multiple injections. Multiple injections of PRP exert a chondroprotective effect, but only in the short term. This effect is not seen with a single injection of PRP.Clinical Relevance:This study provides insight into the histological basis for the superiority of multiple injections of PRP.

scholarly journals Elevated adiabatic T 1ρ and T 2ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study

2017 ◽  
Vol 46 (3) ◽  
pp. 678-689 ◽  
Author(s):  
Victor Casula ◽  
Mikko J. Nissi ◽  
Jana Podlipská ◽  
Marianne Haapea ◽  
Juhani M. Koski ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Bone Lesions ◽  
Early Osteoarthritis ◽  
Preliminary Study

scholarly journals Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage

2015 ◽  
Vol 48 (12) ◽  
pp. 3369-3376 ◽  
Author(s):  
J.T.A Mäkelä ◽  
S-K Han ◽  
W Herzog ◽  
R.K Korhonen
Keyword(s):  
Fluid Flow ◽  
Articular Cartilage ◽  
Flow Properties ◽  
Early Osteoarthritis
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