ROC analysis of informativeness of mapping of the ellipticity distributions of blood plasma films laser images polarization in the evaluation of pathological changes in the breast

2020 ◽  
Author(s):  
Nataliia I. Zabolotna ◽  
Heorhii H. Okarskyi ◽  
Sergei V. Pavlov ◽  
Vladyslava V. Sholota ◽  
Olexander . Turskyi ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Roc Analysis ◽  
Pathological Changes

Information content of the space-frequency filtering of blood plasma layers laser images in the diagnosis of pathological changes

2013 ◽  
Author(s):  
A. G. Ushenko ◽  
T. M. Boychuk ◽  
O. P. Mincer ◽  
G. B. Bodnar ◽  
L. Ya. Kushnerick ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Information Content ◽  
Pathological Changes ◽  
Frequency Filtering ◽  
Space Frequency

scholarly journals Effects of blood pathological changes before TAI on pregnancy of dairy cows with anestrus and estrus

2021 ◽  
Vol 73 (1) ◽  
pp. 1-10
Author(s):  
Y. Di ◽  
C. Zhao ◽  
Y. Bai ◽  
D. Wang ◽  
F. Zhang ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Artificial Insemination ◽  
Neurotrophic Factor ◽  
Roc Analysis ◽  
Pathological Changes ◽  
Pregnancy Test ◽  
Estrus Detection ◽  
Pregnancy Testing ◽  
Negative Pregnancy Test ◽  
Timed Artificial Insemination

ABSTRACT The objective of this study was to investigate the influence of plasma pathological changes before timed artificial insemination (TAI) on pregnancy of cows. The contents of estrogen (E2), progesterone (P4), glucose (Glu), selenium (Se), brain-derived neurotrophic factor (BDNF), and histamine (HIS) in plasma of 48 Holstein cows were measured before TAI. According to the estrus detection, the cows were divided into estrus (E) and anestrus (A) groups. After pregnancy testing at 28 d after TAI, two groups of E and A were divided into positive pregnancy of E group (EP+), negative pregnancy of E group (EP-), positive pregnancy of A group (AP+), and negative pregnancy of A group (AP-). The contents of E2, P4, Glu, Se, BDNF and hIS significantly differed among the four groups (P<0.01). The ROC analysis was used to determine the risk of negative pregnancy test (-) after TAI was increased when plasma E2 was less than 46.45 pmol/L in cows before TAI. The changes in E2, P4,hIS, Glu, and BDNF in the blood of natural estrus and natural anestrus cows affected the pregnancy after TAI. the level of E2 in plasma may be used to assess the risk of negative pregnancy after TAI.

scholarly journals PI3K/AKT/mTOR Signalling Inhibitor Chrysophanol Ameliorates Neurobehavioural and Neurochemical Defects in Propionic Acid-induced Experimental Model of Autism

2021 ◽  
Author(s):  
Aarti Sharma ◽  
Sidharth Mehan
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Blood Plasma ◽  
Rat Brain ◽  
Forced Swim Test ◽  
Brain Homogenate ◽  
Autism Spectrum ◽  
Pathological Changes ◽  
And Oxidative Stress ◽  
Mtor Signalling

Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social-communication deficits and repetitive behaviour. Several studies have revealed that overactivation of the PI3K/AKT/mTOR signalling pathways during brain development plays an important role in the pathogenesis of autism. The PI3K/AKT/mTOR signalling pathway overexpression produces neurological abnormalities by increasing cell death, neuroinflammation, and oxidative stress. Chrysophanol, also known as chrysophanic acid, is a natural substance derived from the plant Rheum palmatum, a well-known Chinese herbal remedy with potential pharmacological applications. The purpose of this study was to look into the neuroprotective effect of CPH on neurobehavioral, molecular, neurochemical, and gross pathological changes in ICV-PPA-induced autism-like rats, with a particular emphasis on its effect on PI3K/AKT/mTOR downregulation in the brain. Furthermore, we looked at how CPH affected the levels of myelin basic protein (MBP) in rat brain homogenate, as well as apoptotic markers such caspase-3, Bax, and Bcl-2 levels in rat brain homogenate and blood plasma samples. Rats were examined for behavioural abnormalities, like neuromuscular dysfunction using actophotometer, motor coordination by beam crossing task (BCT), depressive behaviour with forced swim test (FST), cognitive deficit, and consolidation of memory using Morris water maze (MWM) task. Prolonged oral CPH administration from day 12 to day 44 of the experimental schedule reduces autistic-like symptoms in PPA-treated rats. In addition, cellular, molecular, cell death markers, neuroinflammatory cytokines, neurotransmitter levels, and oxidative stress indicators have been examined in rat brain homogenates, blood plasma, and CSF samples. The current findings suggest that CPH also restores the altered neurochemical levels and potentially prevents autism-like gross pathological changes, including demyelination volume in the rat brain.

Reversal of cardiomyopathy resulting from prenatal exposure to ethanol

1984 ◽  
Vol 42 ◽  
pp. 716-717
Author(s):  
C. Uphoff ◽  
C. Nyquist-Battie
Keyword(s):  
Prenatal Exposure ◽  
Heart Development ◽  
Membrane Integrity ◽  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
Pathological Changes ◽  
Prenatally Exposed ◽  
Inner Mitochondrial Membrane ◽  
Fetal Alcohol ◽  
Newborn Mice

Fetal Alcohol Syndrone (FAS) is a syndrome with characteristic abnormalities resulting from prenatal exposure to ethanol. In many children with FAS syndrome gross pathological changes in the heart are seen with septal defects the most prevalent abnormality recorded. Few studies in animal models have been performed on the effects of ethanol on heart development. In our laboratory, it has been observed that prenatal ethanol exposure of Swiss albino mice results in abnormal cardiac muscle ultrastructure when mice were examined at birth and compared to pairfed and normal controls. Fig. 1 is an example of the changes that are seen in the ethanol-exposed animals. These changes include enlarged mitochondria with loss of inner mitochondrial membrane integrity and loss of myofibrils. Morphometric analysis substantiated the presence of these alterations from normal cardiac ultrastructure. The present work was undertaken to determine if the pathological changes seen in the newborn mice prenatally exposed to ethanol could be reversed with age and abstinence.

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