Speckle-contrast imaging of pathological tissue microhemodynamics in the development of various diabetes models

2020 ◽  
Author(s):  
Polina A. Dyachenko (Timoshina) ◽  
Denis Alexandrov ◽  
Alla Bucharskaya ◽  
Valery Tuchin
Keyword(s):  
Contrast Imaging ◽  
Speckle Contrast

scholarly journals Nephron blood flow dynamics measured by laser speckle contrast imaging

2011 ◽  
Vol 300 (2) ◽  
pp. F319-F329 ◽  
Author(s):  
Niels-Henrik Holstein-Rathlou ◽  
Olga V. Sosnovtseva ◽  
Alexey N. Pavlov ◽  
William A. Cupples ◽  
Charlotte Mehlin Sorensen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Signal Transmission ◽  
Experimental Studies ◽  
Flow Dynamics ◽  
Laser Speckle ◽  
Tubuloglomerular Feedback ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Blood Flow Dynamics

Tubuloglomerular feedback (TGF) has an important role in autoregulation of renal blood flow and glomerular filtration rate (GFR). Because of the characteristics of signal transmission in the feedback loop, the TGF undergoes self-sustained oscillations in single-nephron blood flow, GFR, and tubular pressure and flow. Nephrons interact by exchanging electrical signals conducted electrotonically through cells of the vascular wall, leading to synchronization of the TGF-mediated oscillations. Experimental studies of these interactions have been limited to observations on two or at most three nephrons simultaneously. The interacting nephron fields are likely to be more extensive. We have turned to laser speckle contrast imaging to measure the blood flow dynamics of 50–100 nephrons simultaneously on the renal surface of anesthetized rats. We report the application of this method and describe analytic techniques for extracting the desired data and for examining them for evidence of nephron synchronization. Synchronized TGF oscillations were detected in pairs or triplets of nephrons. The amplitude and the frequency of the oscillations changed with time, as did the patterns of synchronization. Synchronization may take place among nephrons not immediately adjacent on the surface of the kidney.

scholarly journals Laser speckle contrast imaging for perfusion monitoring during surgical reconstruction of anorectal malformations

2021 ◽  
Vol 66 ◽  
pp. 101793
Author(s):  
Pernilla Stenström ◽  
Rafi Sheikh ◽  
Kristine Hagelsteen ◽  
Johanna Wennström Berggren ◽  
Malin Malmsjö
Keyword(s):  
Anorectal Malformations ◽  
Laser Speckle ◽  
Surgical Reconstruction ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast

scholarly journals Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ata Chizari ◽  
Mirjam J. Schaap ◽  
Tom Knop ◽  
Yoeri E. Boink ◽  
Marieke M. B. Seyger ◽  
...  
Keyword(s):  
Perfusion Imaging ◽  
Laser Speckle ◽  
Psoriatic Skin ◽  
Post Processing ◽  
Speed Of Light ◽  
Contrast Imaging ◽  
Speckle Contrast ◽  
Frame Alignment ◽  
Wide Range ◽  
Perfusion Maps

AbstractEnabling handheld perfusion imaging would drastically improve the feasibility of perfusion imaging in clinical practice. Therefore, we examine the performance of handheld laser speckle contrast imaging (LSCI) measurements compared to mounted measurements, demonstrated in psoriatic skin. A pipeline is introduced to process, analyze and compare data of 11 measurement pairs (mounted-handheld LSCI modes) operated on 5 patients and various skin locations. The on-surface speeds (i.e. speed of light beam movements on the surface) are quantified employing mean separation (MS) segmentation and enhanced correlation coefficient maximization (ECC). The average on-surface speeds are found to be 8.5 times greater in handheld mode compared to mounted mode. Frame alignment sharpens temporally averaged perfusion maps, especially in the handheld case. The results show that after proper post-processing, the handheld measurements are in agreement with the corresponding mounted measurements on a visual basis. The absolute movement-induced difference between mounted-handheld pairs after the background correction is $$16.4\pm 9.3~\%$$ 16.4 ± 9.3 % (mean ± std, $$n=11$$ n = 11 ), with an absolute median difference of $$23.8\%$$ 23.8 % . Realization of handheld LSCI facilitates measurements on a wide range of skin areas bringing more convenience for both patients and medical staff.

scholarly journals Monitoring microvascular perfusion variations with laser speckle contrast imaging using a view-based temporal template method

2017 ◽  
Vol 111 ◽  
pp. 49-59 ◽  
Author(s):  
Mohammad Zaheer Ansari ◽  
Eun-Jeung Kang ◽  
Mioara D. Manole ◽  
Jens P. Dreier ◽  
Anne Humeau-Heurtier
Keyword(s):  
Laser Speckle ◽  
Microvascular Perfusion ◽  
Template Method ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast

Enhancing vascular visualization in laser speckle contrast imaging of blood flow using multi-focus image fusion

2018 ◽  
Vol 12 (1) ◽  
pp. e201800100 ◽  
Author(s):  
Wenzhi Lv ◽  
Yang Wang ◽  
Xiao Chen ◽  
Xiaoxi Fu ◽  
Jinling Lu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Image Fusion ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Focus Image

Depth resolution in multifocus laser speckle contrast imaging

2021 ◽  
Author(s):  
Shuqi Zheng ◽  
Sheng Xiao ◽  
Lisa Kretsge ◽  
Alberto Cruz-Martin ◽  
Jerome Mertz
Keyword(s):  
Depth Resolution ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast
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