Detecting best lag of embedding for modeling spike-wave discharges from experimental data

2020 ◽  
Author(s):  
Anastasiya A. Grishchenko ◽  
Marina V. Sysoeva ◽  
Clementina M. van Rijn ◽  
Ilya V. Sysoev
Keyword(s):  
Experimental Data ◽  
Spike Wave Discharges ◽  
Spike Wave

scholarly journals Estimating complexity of spike-wave discharges with largest Lyapunov exponent in computational models and experimental data

2020 ◽  
Vol 7 (2) ◽  
pp. 65-75
Author(s):  
T. M. Medvedeva ◽  
◽  
A. K. Lüttjohann ◽  
M. V. Sysoeva ◽  
G. van Luijtelaar ◽  
...  
Keyword(s):  
Experimental Data ◽  
Lyapunov Exponent ◽  
Computational Models ◽  
Largest Lyapunov Exponent ◽  
Spike Wave Discharges ◽  
Spike Wave

The zona incerta modulates spontaneous spike-wave discharges in the rat

2013 ◽  
Vol 109 (10) ◽  
pp. 2505-2516 ◽  
Author(s):  
Fu-Zen Shaw ◽  
Yi-Fang Liao ◽  
Ruei-Feng Chen ◽  
Yu-Hsing Huang ◽  
Rick C. S. Lin
Keyword(s):  
Functional Role ◽  
Significant Inhibition ◽  
Zona Incerta ◽  
Obvious Effect ◽  
Spike Wave Discharges ◽  
Long Evans ◽  
Oscillation Frequencies ◽  
Spike Wave ◽  
Stimulation Of

The contribution of the zona incerta (ZI) of the thalamus on spike-wave discharges (SWDs) was investigated. Chronic recordings of bilateral cortices, bilateral vibrissa muscle, and unilateral ZI were performed in Long-Evans rats to examine the functional role of SWDs. Rhythmic ZI activity appeared at the beginning of SWD and was accompanied by higher-oscillation frequencies and larger spike magnitudes. Bilateral lidocaine injections into the mystacial pads led to a decreased oscillation frequency of SWDs, but the phenomenon of ZI-related spike magnitude enhancement was preserved. Moreover, 800-Hz ZI microstimulation terminates most of the SWDs and whisker twitching (WT; >80%). In contrast, 200-Hz ZI microstimulation selectively stops WTs but not SWDs. Stimulation of the thalamic ventroposteriomedial nucleus showed no obvious effect on terminating SWDs. A unilateral ZI lesion resulted in a significant reduction of 7- to 12-Hz power of both the ipsilateral cortical and contralateral vibrissae muscle activities during SWDs. Intraincertal microinfusion of muscimol showed a significant inhibition on SWDs. Our present data suggest that the ZI actively modulates the SWD magnitude and WT behavior.

Profound oxygen desaturation due to central apneas associated with interictal generalized spike-wave discharges

2011 ◽  
Vol 12 (3) ◽  
pp. 302-305
Author(s):  
Brendan P. Lucey ◽  
Cristina Toedebusch ◽  
Stephen P. Duntley
Keyword(s):  
Oxygen Desaturation ◽  
Spike Wave Discharges ◽  
Central Apneas ◽  
Spike Wave

scholarly journals Co-existence of Rolandic and 3 Hz Spike-Wave Discharges on EEG in Children with Epilepsy

2018 ◽  
Vol 46 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Anita N. Datta ◽  
Laura Wallbank ◽  
Peter K. H. Wong
Keyword(s):  
Clinical Data ◽  
Seizure Control ◽  
Age Of Onset ◽  
Absence Epilepsy ◽  
Childhood Absence Epilepsy ◽  
Drug Induced ◽  
Favorable Prognosis ◽  
Spike Wave Discharges ◽  
Spike Wave

AbstractObjectiveBenign epilepsy of childhood with central temporal spikes (BECTS) and absence epilepsy are common epilepsy syndromes in children with similar age of onset and favorable prognosis. However, the co-existence of the electrocardiogram (EEG) findings of rolandic spike and 3 Hz generalized spike-wave (GSW) discharges is extremely rare, with few cases reported in the literature. Our objective was to characterize the EEG findings of these syndromes in children in our center and review the electro-clinical features.MethodsAll EEGs at BC Children’s Hospital are entered in a database, which include EEG findings and clinical data. Patients with both centro-temporal spikes and 3 Hz GSW discharges were identified from the database and clinical data were reviewed.ResultsAmong the 43,061 patients in the database from 1992 to 2017, 1426 with isolated rolandic discharges and 528 patients with isolated 3 Hz GSW discharges were identified, and 20 (0.05%) patients had both findings: 3/20 had BECTS, and subsequently developed childhood absence epilepsy and 17/20 had no seizures characteristic for BECTS. At follow-up, 17 (85%) were seizure-free, 1 (5%) had rare, and 2 (10%) had frequent seizures.ConclusionsThis is the largest reported group of patients to our knowledge with the co-existence of rolandic and 3 Hz GSW discharges on EEGs in one institution, not drug-induced. As the presence of both findings is extremely rare, distinct pathophysiological mechanisms are likely. The majority had excellent seizure control at follow-up, similar to what would be expected for each type of epilepsy alone.

scholarly journals Towards a large-scale model of patient-specific epileptic spike-wave discharges

2012 ◽  
Vol 107 (1) ◽  
pp. 83-94 ◽  
Author(s):  
Peter Neal Taylor ◽  
Marc Goodfellow ◽  
Yujiang Wang ◽  
Gerold Baier
Keyword(s):  
Large Scale ◽  
Scale Model ◽  
Patient Specific ◽  
Large Scale Model ◽  
Spike Wave Discharges ◽  
Epileptic Spike ◽  
Spike Wave
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