Impact of proton radiation on the Ariel AIRS CH1 HAWAII-1RG MWIR detector

2020 ◽  
Author(s):  
Pierre-Elie Crouzet ◽  
Brian Shortt ◽  
Thierry Beaufort ◽  
Sander Blommaert ◽  
Gertjan Van Duinkerken ◽  
...  
Keyword(s):  
Proton Radiation

scholarly journals Targeting the DNA replication stress phenotype of KRAS mutant cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tara Al Zubaidi ◽  
O. H. Fiete Gehrisch ◽  
Marie-Michelle Genois ◽  
Qi Liu ◽  
Shan Lu ◽  
...  
Keyword(s):  
Dna Replication ◽  
Single Molecule ◽  
Replication Stress ◽  
Proton Radiation ◽  
Wild Type ◽  
Cellular Effects ◽  
Proton Treatment ◽  
Dna Replication Stress ◽  
Fork Stalling ◽  
Mutant Cells

AbstractMutant KRAS is a common tumor driver and frequently confers resistance to anti-cancer treatments such as radiation. DNA replication stress in these tumors may constitute a therapeutic liability but is poorly understood. Here, using single-molecule DNA fiber analysis, we first characterized baseline replication stress in a panel of unperturbed isogenic and non-isogenic cancer cell lines. Correlating with the observed enhanced replication stress we found increased levels of cytosolic double-stranded DNA in KRAS mutant compared to wild-type cells. Yet, despite this phenotype replication stress-inducing agents failed to selectively impact KRAS mutant cells, which were protected by CHK1. Similarly, most exogenous stressors studied did not differentially augment cytosolic DNA accumulation in KRAS mutant compared to wild-type cells. However, we found that proton radiation was able to slow fork progression and preferentially induce fork stalling in KRAS mutant cells. Proton treatment also partly reversed the radioresistance associated with mutant KRAS. The cellular effects of protons in the presence of KRAS mutation clearly contrasted that of other drugs affecting replication, highlighting the unique nature of the underlying DNA damage caused by protons. Taken together, our findings provide insight into the replication stress response associated with mutated KRAS, which may ultimately yield novel therapeutic opportunities.

Effect of proton radiation on 8T CMOS image sensors for space applications

2021 ◽  
pp. 1-9
Author(s):  
Jing Fu ◽  
Jie Feng ◽  
Yu-Dong Li ◽  
Qi Guo ◽  
Ying Wei ◽  
...  
Keyword(s):  
Image Sensors ◽  
Proton Radiation ◽  
Space Applications ◽  
Cmos Image Sensors

scholarly journals Heart to Heart: Excess Cardiac Risk between Photon and Proton Radiation in the Treatment of Breast Cancer

2020 ◽  
Vol 108 (3) ◽  
pp. e50
Author(s):  
J.A. Bradley ◽  
T.Y.D. Chen ◽  
S. Omer ◽  
L. Yaghjyan ◽  
R. Mailhot Vega ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiac Risk ◽  
Proton Radiation

Individual Differences in Attentional Deficits and Dopaminergic Protein Levels following Exposure to Proton Radiation

2014 ◽  
Vol 181 (3) ◽  
pp. 258-271 ◽  
Author(s):  
Catherine M. Davis ◽  
Kathleen L. DeCicco-Skinner ◽  
Peter G. Roma ◽  
Robert D. Hienz
Keyword(s):  
Individual Differences ◽  
Proton Radiation ◽  
Attentional Deficits ◽  
Protein Levels

Single Room Proton Radiation Therapy

2012 ◽  
Vol 84 (3) ◽  
pp. S835-S836
Author(s):  
E.E. Klein ◽  
C. Block ◽  
B. Pierburg ◽  
J. Bradley
Keyword(s):  
Radiation Therapy ◽  
Proton Radiation ◽  
Proton Radiation Therapy ◽  
Single Room
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