Next-generation exhaled breath diagnostics via combined biophotonics: seeing more by looking at less (Conference Presentation)

Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer

Anticancer Research ◽

10.21873/anticanres.12897 ◽

2018 ◽

Vol 38 (10) ◽

pp. 5627-5634 ◽

Cited By ~ 8

Author(s):

OMAR YOUSSEF ◽

AIJA KNUUTTILA ◽

PÄIVI PIIRILÄ ◽

TOM BÖHLING ◽

VIRINDER SARHADI ◽

...

Keyword(s):

Lung Cancer ◽

Next Generation Sequencing ◽

Exhaled Breath ◽

Next Generation ◽

Hotspot Mutations ◽

Generation Sequencing

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Detection of cancer associated mutations in exhaled breath condensates of healthy subjects by next generation sequencing

Annals of Oncology ◽

10.1093/annonc/mdx508.025 ◽

2017 ◽

Vol 28 ◽

pp. vii11

Author(s):

O. Youssef ◽

A. Knuuttila ◽

P. Piirilä ◽

T. Böhling ◽

V. Sarhadi ◽

...

Keyword(s):

Next Generation Sequencing ◽

Healthy Subjects ◽

Exhaled Breath ◽

Next Generation ◽

Generation Sequencing

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Next-Generation Digital Biomarkers for Tuberculosis and Antibiotic Stewardship: Perspective on Novel Molecular Digital Biomarkers in Sweat, Saliva, and Exhaled Breath

Journal of Medical Internet Research ◽

10.2196/25907 ◽

2021 ◽

Vol 23 (8) ◽

pp. e25907

Author(s):

Noe Brasier ◽

Michael Osthoff ◽

Fiorangelo De Ieso ◽

Jens Eckstein

Keyword(s):

Health Care ◽

Infectious Diseases ◽

Low Income ◽

Health Care Professionals ◽

Smart Devices ◽

Therapeutic Drug ◽

Exhaled Breath ◽

Accelerometer Data ◽

Next Generation ◽

Digital Biomarkers

The internet of health care things enables a remote connection between health care professionals and patients wearing smart biosensors. Wearable smart devices are potentially affordable, sensitive, specific, user-friendly, rapid, robust, lab-independent, and deliverable to the end user for point-of-care testing. The datasets derived from these devices are known as digital biomarkers. They represent a novel patient-centered approach to collecting longitudinal, context-derived health insights. Adding automated, analytical smartphone applications will enable their use in high-, middle-, and low-income countries. So far, digital biomarkers have been focused primarily on accelerometer data and heart rate due to well-established sensors originating from the consumer market. Novel emerging smart biosensors will detect biomarkers (or compounds) independent of a lab and noninvasively in sweat, saliva, and exhaled breath. These molecular digital biomarkers are a promising novel approach to reduce the burden from 2 major infectious diseases with urgent unmet needs: tuberculosis and infections with multidrug resistant pathogens. Active tuberculosis (aTbc) is one of the deadliest diseases from an infectious agent. However, a simple and reliable test for its detection is still missing. Furthermore, inappropriate antimicrobial use leads to the development of antimicrobial resistance, which is associated with high mortality and health care costs. From this perspective, we discuss the innovative approach of a noninvasive and lab-independent collection of novel biomarkers to detect aTbc, which at the same time may additionally serve as a scalable therapeutic drug monitoring approach for antibiotics. These molecular digital biomarkers are next-generation digital biomarkers and have the potential to shape the future of infectious diseases.

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Next-Generation Digital Biomarkers for Tuberculosis and Antibiotic Stewardship: Perspective on Novel Molecular Digital Biomarkers in Sweat, Saliva, and Exhaled Breath (Preprint)

10.2196/preprints.25907 ◽

2020 ◽

Author(s):

Noe Brasier ◽

Michael Osthoff ◽

Fiorangelo De Ieso ◽

Jens Eckstein

Keyword(s):

Health Care ◽

Infectious Diseases ◽

Low Income ◽

Health Care Professionals ◽

Smart Devices ◽

Therapeutic Drug ◽

Exhaled Breath ◽

Accelerometer Data ◽

Next Generation ◽

Digital Biomarkers

UNSTRUCTURED The internet of health care things enables a remote connection between health care professionals and patients wearing smart biosensors. Wearable smart devices are potentially affordable, sensitive, specific, user-friendly, rapid, robust, lab-independent, and deliverable to the end user for point-of-care testing. The datasets derived from these devices are known as digital biomarkers. They represent a novel patient-centered approach to collecting longitudinal, context-derived health insights. Adding automated, analytical smartphone applications will enable their use in high-, middle-, and low-income countries. So far, digital biomarkers have been focused primarily on accelerometer data and heart rate due to well-established sensors originating from the consumer market. Novel emerging smart biosensors will detect biomarkers (or compounds) independent of a lab and noninvasively in sweat, saliva, and exhaled breath. These molecular digital biomarkers are a promising novel approach to reduce the burden from 2 major infectious diseases with urgent unmet needs: tuberculosis and infections with multidrug resistant pathogens. Active tuberculosis (aTbc) is one of the deadliest diseases from an infectious agent. However, a simple and reliable test for its detection is still missing. Furthermore, inappropriate antimicrobial use leads to the development of antimicrobial resistance, which is associated with high mortality and health care costs. From this perspective, we discuss the innovative approach of a noninvasive and lab-independent collection of novel biomarkers to detect aTbc, which at the same time may additionally serve as a scalable therapeutic drug monitoring approach for antibiotics. These molecular digital biomarkers are next-generation digital biomarkers and have the potential to shape the future of infectious diseases.

Download Full-text