Quantitative assessment of the breast tumor stroma using cross-polarization OCT and multiphoton tomography

2020 ◽  
Author(s):  
Ekaterina V. Gubarkova ◽  
Vadim Elagin ◽  
Alexander A. Moiseev ◽  
Varvara Dudenkova ◽  
Elena Kiseleva ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Quantitative Assessment ◽  
Tumor Stroma ◽  
Cross Polarization ◽  
Multiphoton Tomography

Abstract P6-02-07: In vitro 3D Model of Breast Tumor Stroma

2012 ◽  
Author(s):  
H Jaganathan ◽  
S Mitra ◽  
B Dave ◽  
B Godin
Keyword(s):  
Breast Tumor ◽  
3D Model ◽  
Tumor Stroma

Abstract A43: Systemic tumor-stroma interactions are prognostic indicators of breast tumor invasiveness

2015 ◽  
Author(s):  
Casey A. Frankenberger ◽  
Russell O. Bainer ◽  
Daniel C. Rabe ◽  
Sadiq Saleh ◽  
Morag Park ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Tumor Stroma ◽  
Prognostic Indicators ◽  
Tumor Invasiveness

Neutralizing CCL2 Inhibits Breast Tumor Growth Via Impact on the Tumor/Stroma Microenvironment.

2009 ◽  
Author(s):  
L. Campion ◽  
F. Shi ◽  
E. Kaiser ◽  
L. Johns ◽  
D. Egenolf ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Breast Tumor ◽  
Tumor Stroma

Abstract LB-320: Systemic tumor-stroma interactions are prognostic indicators of breast tumor invasiveness

2014 ◽  
Author(s):  
Russell Bainer ◽  
Casey Frankenberger ◽  
Daniel Rabe ◽  
Sadiq Saleh ◽  
Morag Park ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Tumor Stroma ◽  
Prognostic Indicators ◽  
Tumor Invasiveness

scholarly journals Breast adipose tissue macrophages (BATMs) have a stronger correlation with breast cancer survival than breast tumor stroma macrophages (BTSMs)

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Lili Lin ◽  
Christina Kuhn ◽  
Nina Ditsch ◽  
Thomas Kolben ◽  
Bastian Czogalla ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Breast Tumor ◽  
Poor Prognosis ◽  
Tumor Stroma ◽  
Cox Regression Analysis ◽  
Negatively Associated ◽  
Adipose Tissue Macrophages ◽  
Breast Adipose Tissue ◽  
Breast Adipose

Abstract Background An abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the breast and has also been identified as an independent indicator of poor survival in BC. This study aims to elucidate if the influence of adipose tissue in BC might be mediated by macrophages. The roles of macrophages in the breast tumor-stroma (breast tumor stroma macrophages, BTSM) and macrophages in the surrounding adipose tissue (breast adipose tissue macrophages, BATM) were explored separately. Methods Two hundred ninety-eight BC tissue samples were analyzed immunohistochemically. The number of macrophages was detected by CD68+ staining. The quantity of BATMs and BTSMs was correlated to clinical and pathological parameters as well as to disease-free survival (DFS) and overall survival (OS). Results The amounts of BATMs and BTSMs strongly correlated with each other (r = 0.5, p = 2.98E−15). The quantity of BTSMs, but not of BATMs, was significantly associated with the BC molecular subtype (p = 0.000011), and all triple-negative BC tumors contained high amounts of BTSMs. BATMs were negatively associated with DFS (p = 0.0332). Both BATMs (p = 0.000401) and BTSMs (p = 0.021) were negatively associated with OS in the Kaplan-Meier analysis, but only BATMs remained an independent factor in the multivariate Cox-regression analysis (HR = 4.464, p = 0.004). Combining prostaglandin E2 receptor 3 (EP3)-expression and the quantity of BATMs, a subgroup with an extremely poor prognosis could be identified (median OS 2.31 years in the “high BATMs/low EP3” subgroup compared to 11.42 years in the most favorable “low BATMs/high EP3” subgroup, p = 0.000002). Conclusion Our findings suggest that BTSMs and BATMs seem to be involved differently in BC. Breast adipose tissue might contribute to the aggressiveness of BC via BATMs, which were independently associated with BC survival. BATMs’ role and occurrence might be functionally dependent on EP3, as a combination of both factors was strongly associated with survival. Targeting BATMs—eventually in combination with targeting the EP3-pathway—might be promising for future therapies.

scholarly journals Breast Adipose Tissue Macrophages (BATMs) have a Stronger Correlation with Breast Cancer Survival than Breast Tumor Stroma Macrophages (BTSMs)

2020 ◽  
Author(s):  
Lili Lin ◽  
Christina Kuhn ◽  
Nina Ditsch ◽  
Thomas Kolben ◽  
Bastian Czogalla ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Breast Tumor ◽  
Poor Prognosis ◽  
Tumor Stroma ◽  
Cox Regression Analysis ◽  
Negatively Associated ◽  
Adipose Tissue Macrophages ◽  
Breast Adipose Tissue ◽  
Breast Adipose

Abstract Background: An abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the breast and has also been identified as an independent indicator of poor survival in BC. This study aims to elucidate, if the influence of adipose tissue in BC might be mediated by macrophages. The roles of macrophages in the breast tumor-stroma (breast tumor stroma macrophages, BTSM) and macrophages in the surrounding adipose tissue (breast adipose tissue macrophages, BATM) were explored separately.Methods: 298 BC tissue samples were analyzed immunohistochemically. The number of macrophages was detected by CD68+ staining. The quantity of BATMs and BTSMs was correlated to clinical and pathological parameters as well as to disease free survival (DFS) and overall survival (OS). Results: The amounts of BATMs and BTSMs strongly correlated with each other (r = 0.5, p < 0.001). The quantity of BTSMs, but not of BATMs, was significantly associated with the BC molecular subtype (p < 0.001) and all triple negative BC tumors contained high amounts of BTSMs. BATMs were negatively associated with DFS (p = 0.0332). Both BATMs (p < 0.001) and BTSMs (p = 0.021) were negatively associated with OS in the Kaplan-Meier analysis, but only BATMs remained an independent factor in the multivariate Cox-regression analysis (HR = 4.464, p = 0.004). Combining prostaglandin E2 receptor 3 (EP3)-expression and the quantity of BATMs, a subgroup with an extremely poor prognosis could be identified (median OS 2.31 years in the “high BATMs/low EP3” subgroup compared to 11.42 years in the most favorable “low BATMs/high EP3” subgroup, p < 0.001).Conclusion: Our findings suggest that BTSMs and BATMs seem to be involved differently in BC. Breast adipose tissue might contribute to the aggressiveness of BC via BATMs, which were independently associated with BC survival. BATMs’ role and occurrence might be functionally dependent on EP3, as a combination of both factors was strongly associated with survival. Targeting BATMs – eventually in combination with targeting the EP3-pathway – might be promising for future therapies.

scholarly journals Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression

Oncotarget ◽  
2015 ◽  
Vol 6 (26) ◽  
pp. 22081-22097 ◽  
Author(s):  
María Laura Polo ◽  
Marina Riggio ◽  
María May ◽  
María Jimena Rodríguez ◽  
María Cecilia Perrone ◽  
...  
Keyword(s):  
Endocrine Therapy ◽  
Breast Tumor ◽  
Tumor Regression ◽  
Tumor Stroma ◽  
Mtor Signaling

scholarly journals Pten in the Breast Tumor Microenvironment: Modeling Tumor–Stroma Coevolution: Figure 1.

2011 ◽  
Vol 71 (4) ◽  
pp. 1203-1207 ◽  
Author(s):  
Julie A. Wallace ◽  
Fu Li ◽  
Gustavo Leone ◽  
Michael C. Ostrowski
Keyword(s):  
Tumor Microenvironment ◽  
Breast Tumor ◽  
Tumor Stroma

scholarly journals Multiphoton Tomography and Cross-Polarization Optical Coherence Tomography for Diagnosing Brain Gliomas: Pilot Study

2016 ◽  
Vol 8 (4) ◽  
pp. 64-75 ◽  
Author(s):  
V.V. Dudenkova ◽  
K.S. Yashin ◽  
E.B. Kiseleva ◽  
S.S. Kuznetsov ◽  
L.B. Timofeeva ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Pilot Study ◽  
Optical Coherence ◽  
Cross Polarization ◽  
Multiphoton Tomography ◽  
Brain Gliomas
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