Near-infrared phototheranostics: optical imaging and light induced therapy (Conference Presentation)

2020 ◽  
Author(s):  
Tymish Y. Ohulchanskyy
Keyword(s):  
Optical Imaging ◽  
Near Infrared

scholarly journals Micelle-based activatable probe for in vivo near-infrared optical imaging of cancer biomolecules

2014 ◽  
Vol 10 (1) ◽  
pp. 187-195 ◽  
Author(s):  
Yoichi Shimizu ◽  
Takashi Temma ◽  
Isao Hara ◽  
Akira Makino ◽  
Ryo Yamahara ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Near Infrared ◽  
Activatable Probe

scholarly journals Assessment of Endothelin-A Receptor Expression in Subcutaneous and Orthotopic Thyroid Carcinoma Xenografts in Vivo Employing Optical Imaging Methods

Endocrinology ◽  
2012 ◽  
Vol 153 (6) ◽  
pp. 2907-2918 ◽  
Author(s):  
Katrin Büther ◽  
Matthijs G. Compeer ◽  
Jo G. R. De Mey ◽  
Otmar Schober ◽  
Michael Schäfers ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Optical Imaging ◽  
Near Infrared ◽  
Functional Performance ◽  
Thyroid Tumor ◽  
Receptor Expression ◽  
Imaging Methods ◽  
Carcinoma Cell Lines ◽  
Isolated Artery

Endothelin (ET) receptor dysregulation has been described in a number of pathophysiological processes, including cardiovascular disorders, renal failure, and cancer. The aim of this study was to evaluate the expression of the ET-A receptor (ETAR) in murine models of thyroid carcinoma using optical imaging methods. A recently developed near-infrared fluorescent tracer was first assessed in isolated artery preparations for its functional performance in comparison with known ETAR antagonists BQ123 and PD156707. Before evaluation of the tracer in vivo, different thyroid carcinoma cell lines were characterized with respect to their ET receptor expression by RT-PCR and autoradiography. In vivo, sc and orthotopic papillary thyroid tumor xenografts were clearly visualized by fluorescence reflectance imaging and fluorescence-mediated tomography up to 48 h after injection of the tracer. Binding specificity of the probe was demonstrated by predosing with PD156707 as a competing inhibitor. In conclusion, optical imaging with a fluorescent ETAR tracer allows the noninvasive imaging of tumor-associated ETAR expression in vivo. In the future, this technique may help surgeons to evaluate lesion dimensions in intraoperative settings (e.g. thyroidectomy).

scholarly journals Role of Fluorophore Charge on the In Vivo Optical Imaging Properties of Near-Infrared Cyanine Dye/Monoclonal Antibody Conjugates

2015 ◽  
Vol 27 (2) ◽  
pp. 404-413 ◽  
Author(s):  
Kazuhide Sato ◽  
Alexander P. Gorka ◽  
Tadanobu Nagaya ◽  
Megan S. Michie ◽  
Roger R. Nani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Optical Imaging ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Antibody Conjugates ◽  
Imaging Properties ◽  
In Vivo Optical Imaging

scholarly journals Correction: Optical imaging of ovarian cancer using a matrix metalloproteinase-3-sensitive near-infrared fluorescent probe

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202610
Author(s):  
Kuo-Hwa Wang ◽  
Yun-Ming Wang ◽  
Li-Hsuan Chiu ◽  
Tze-Chien Chen ◽  
Yu-Hui Tsai ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Matrix Metalloproteinase ◽  
Optical Imaging ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Matrix Metalloproteinase 3

scholarly journals Targeted zwitterionic near-infrared fluorophores for improved optical imaging

2013 ◽  
Vol 31 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Hak Soo Choi ◽  
Summer L Gibbs ◽  
Jeong Heon Lee ◽  
Soon Hee Kim ◽  
Yoshitomo Ashitate ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Near Infrared

scholarly journals Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting α3 integrin

2008 ◽  
Vol 36 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Wenwu Xiao ◽  
Nianhuan Yao ◽  
Li Peng ◽  
Ruiwu Liu ◽  
Kit S. Lam
Keyword(s):  
Optical Imaging ◽  
Near Infrared ◽  
Α3 Integrin

Near-infrared Fluorescence Optical Imaging in Early Rheumatoid Arthritis: A Comparison to Magnetic Resonance Imaging and Ultrasonography

2015 ◽  
Vol 42 (7) ◽  
pp. 1112-1118 ◽  
Author(s):  
Michaela Krohn ◽  
Sarah Ohrndorf ◽  
Stephanie G. Werner ◽  
Bernd Schicke ◽  
Gerd-Rüdiger Burmester ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Early Rheumatoid Arthritis ◽  
Near Infrared ◽  
Resonance Imaging ◽  
Near Infrared Fluorescence ◽  
Fluorescence Optical Imaging ◽  
Early Ra

Objective.Near-infrared fluorescence optical imaging (FOI) is a novel imaging technology in the detection and evaluation of different arthritides. FOI was validated in comparison to magnetic resonance imaging (MRI), greyscale ultrasonography (GSUS), and power Doppler ultrasonography (PDUS) in patients with early rheumatoid arthritis (RA).Methods.Hands of 31 patients with early RA were examined by FOI, MRI, and US. In each modality, synovitis of the wrist, metacarpophalangeal joints (MCP) 2–5, and proximal interphalangeal joints (PIP) 2–5 were scored on a 4-point scale (0–3). Sensitivity and specificity of FOI were analyzed in comparison to MRI and US as reference methods, differentiating between 3 phases of FOI enhancement (P1–3). Intraclass correlation coefficients (ICC) were calculated to evaluate the agreement of FOI with MRI and US.Results.A total of 279 joints (31 wrists, 124 MCP and 124 PIP joints) were evaluated. With MRI as the reference method, overall sensitivity/specificity of FOI was 0.81/0.00, 0.49/0.84, and 0.86/0.38 for wrist, MCP, and PIP joints, respectively. Under application of PDUS as reference, sensitivity was even higher, while specificity turned out to be low, except for MCP joints (0.88/0.15, 0.81/0.76, and 1.00/0.27, respectively). P2 appears to be the most sensitive FOI phase, while P1 showed the highest specificity. The best agreement of FOI was shown for PDUS, especially with regard to MCP and PIP joints (ICC of 0.57 and 0.53, respectively), while correlation with MRI was slightly lower.Conclusion.FOI remains an interesting diagnostic tool for patients with early RA, although this study revealed limitations concerning the detection of synovitis. Further research is needed to evaluate its full diagnostic potential in rheumatic diseases.

CLASSIFICATION OF SCHIZOPHRENIA USING SVM VIA fNIRS

2018 ◽  
Vol 30 (02) ◽  
pp. 1850008 ◽  
Author(s):  
Mehrdad Dadgostar ◽  
Seyed Kamaledin Setarehdan ◽  
Sohrab Shahzadi ◽  
Ata Akin
Keyword(s):  
Mental Disorder ◽  
Optical Imaging ◽  
Near Infrared ◽  
Continuous Wave ◽  
Support Vector ◽  
Functional Near Infrared Spectroscopy ◽  
Neural Activities ◽  
Preliminary Examination ◽  
Invasive Method

In the present study, a classification of functional near-infrared spectroscopy (fNIRS) based on support vector machine (SVM) is presented. It is a non-invasive method monitoring human brain function by evaluating the concentration variation of oxy-hemoglobin and deoxy-hemoglobin. fNIRS is a functional optical imaging technology that measures the neural activities and hemodynamic responses in brain. The data were gathered from 11 healthy volunteers and 16 schizophrenia of the same average age by a 16-channel fNIRS (NIROXCOPE 301 system developed at the Neuro-Optical Imaging Laboratory, continuous-wave dual wavelength). Schizophrenia is a mental disorder that is characterized by mental processing collapse and weak emotional responses. This mental disorder is usually accompanied by a serious disturbance in social and occupational activities. The signals were initially preprocessed by DWT to remove any systemic physiological impediment. A preliminary examination by the genetic algorithm (GA) suggested that some channels of the recreated fNIRS signals required further investigation. The energy of these recreated channel signals was computed and utilized for signal arrangement. We used SVM-based classifier to determine the cases of schizophrenia. The result of six channels is higher than 16 channels. The results demonstrated a classification precision of about 87% in the discovery of schizophrenia in the healthy subjects.

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