An implementation of data assimilation techniques for transmural visualization of action potential propagation in cardiac tissue

2020 ◽  
Author(s):  
Christopher Beam ◽  
Cristian A. Linte ◽  
Niels F. Otani
Keyword(s):  
Data Assimilation ◽  
Action Potential ◽  
Cardiac Tissue ◽  
Action Potential Propagation

scholarly journals Reply to Entcheva: The impact of T-tubules on action potential propagation in cardiac tissue

2018 ◽  
Vol 115 (4) ◽  
pp. E562-E563
Author(s):  
M. Scardigli ◽  
C. Crocini ◽  
C. Ferrantini ◽  
T. Gabbrielli ◽  
L. Silvestri ◽  
...  
Keyword(s):  
Action Potential ◽  
Cardiac Tissue ◽  
Action Potential Propagation ◽  
T Tubules ◽  
The Impact

EFFECT OF CARDIAC TISSUE ANISOTROPY ON THREE-DIMENSIONAL ELECTRICAL ACTION POTENTIAL PROPAGATION

2010 ◽  
Vol 24 (17) ◽  
pp. 1847-1853 ◽  
Author(s):  
ZHI ZHU HE ◽  
JING LIU
Keyword(s):  
Action Potential ◽  
Computational Models ◽  
Cardiac Tissue ◽  
Three Dimensional ◽  
Propagation Model ◽  
Spatial Inhomogeneity ◽  
Cardiac Tissues ◽  
Action Potential Propagation ◽  
Self Similar ◽  
Tissue Anisotropy

A three-dimensional (3D) electrical action potential propagation model is developed to characterize the integrated effect of cardiac tissue structure using a homogenous function with a spatial inhomogeneity. This method may be more effective for bridging the gap between computational models and experimental data for cardiac tissue anisotropy. A generalized 3D eikonal relation considering anisotropy and a self-similar evolution solution of such a relation are derived to identify the effect of anisotropy and predict the anisotropy-induced electrical wave propagation instabilities. Furthermore, the phase field equation is introduced to obtain the complex three-dimensional numerical solution of the new correlation. The present results are expected to be valuable for better understanding the physiological behavior of cardiac tissues.

scholarly journals Simulation of Ectopic Pacemakers in the Heart: Multiple Ectopic Beats Generated by Reentry inside Fibrotic Regions

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Bruno Gouvêa de Barros ◽  
Rodrigo Weber dos Santos ◽  
Marcelo Lobosco ◽  
Sergio Alonso
Keyword(s):  
Action Potential ◽  
Discrete Model ◽  
Animal Studies ◽  
Cardiac Fibrosis ◽  
Cardiac Tissue ◽  
Microscopic Model ◽  
Ectopic Beat ◽  
Action Potential Propagation ◽  
Ectopic Beats ◽  
Heterogeneous Tissue

The inclusion of nonconducting media, mimicking cardiac fibrosis, in two models of cardiac tissue produces the formation of ectopic beats. The fraction of nonconducting media in comparison with the fraction of healthy myocytes and the topological distribution of cells determines the probability of ectopic beat generation. First, a detailed subcellular microscopic model that accounts for the microstructure of the cardiac tissue is constructed and employed for the numerical simulation of action potential propagation. Next, an equivalent discrete model is implemented, which permits a faster integration of the equations. This discrete model is a simplified version of the microscopic model that maintains the distribution of connections between cells. Both models produce similar results when describing action potential propagation in homogeneous tissue; however, they slightly differ in the generation of ectopic beats in heterogeneous tissue. Nevertheless, both models present the generation of reentry inside fibrotic tissues. This kind of reentry restricted to microfibrosis regions can result in the formation of ectopic pacemakers, that is, regions that will generate a series of ectopic stimulus at a fast pacing rate. In turn, such activity has been related to trigger fibrillation in the atria and in the ventricles in clinical and animal studies.

Sign in / Sign up

Export Citation Format

Share Document