Sequential reading effects in Dutch screening mammography

Great importance in detecting cancer in the phase of in situ lays in the fact that the epithelial layer is deprived of blood and lymph vessels, so metastases may develop only when basal membrane has been broken. This paper includes 46 operated women in whom it preoperatively had been verified suspect non-palpable lesion. The preoperative diagnostics included use of high- resolution mammography, aimed mammography, palpatory examination, as well as fine-needle aspiration (FNA), biopsy and cytologic analysis of the sample. The methodology of this work implies the use of stereotaxic marking, specimen mammography and ex-tempore pathohistology analysis. Out of 46 investigated patients in clinical stage T0N0M0, in whom there were no signs of malignant disease, and according to suspect lesion of initial screening mammography, malignant lesions of breast tissue were diagnosed in 19 patients (41%) intraoperatively. Three of these lesions (15,8%) were histopathologically verified as in situ. Comparing our results with data of the Institute of oncology and radiology of Serbia hospital registry (IORS) for the year 2001, from 1173 patients registered with malignant lesions, only 16 ones (1,4%) had in situ cancer, operated on the basis of the suspect mammography of clinical stage T0N0M0. Statistically significant difference was found related to the number of detected cancers in this early phase of the breast malignant disease. This limits surgical intervention to tumorectomy, with preservation of the remaining breast tissue, what brings to healing, justifying in that way, screening examinations and routine application of the most contemporary diagnostic procedures.

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DeepCAT: Deep Computer-Aided Triage of Screening Mammography

Journal of Digital Imaging ◽

10.1007/s10278-020-00407-0 ◽

2021 ◽

Vol 34 (1) ◽

pp. 27-35

Author(s):

Paul H. Yi ◽

Dhananjay Singh ◽

Susan C. Harvey ◽

Gregory D. Hager ◽

Lisa A. Mullen

Keyword(s):

Screening Mammography ◽

Computer Aided

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Assessing Biomarkers of Breast Cancer Risk in Underserved Women in a Midwestern County

Journal of Primary Care & Community Health ◽

10.1177/21501327211017792 ◽

2021 ◽

Vol 12 ◽

pp. 215013272110177

Author(s):

Marla A. DeWitt ◽

Ivana T. Croghan ◽

Celine M. Vachon ◽

Thomas D. Thacher ◽

Marcia R. Venegas Pont ◽

...

Keyword(s):

Vitamin D ◽

Mammographic Density ◽

Small Sample Size ◽

Vitamin D Insufficiency ◽

Screening Mammography ◽

Small Sample ◽

Vitamin D Status ◽

Small Pilot Study ◽

Unexpected Findings

Objective: The primary aim of this study was to evaluate the feasibility of collecting risk factor information and accessing digitized mammographic data in a medically marginalized population. A secondary aim was to examine the association between vitamin D status and mammographic density. Methods: Breast-screening examinations were provided for age-appropriate patients, and a referral for no-cost screening mammography was offered. Study participants were asked to undergo 25-hydroxyvitamin D testing at mammography and 1-year follow-up. Results: Of 62 women approached, 35 (56%) consented to participate. Of 32 participants who had baseline mammography, the median mammographic density measured by VolparaDensity (Volpara Solutions Limited) was 5.7%. After 1 year, 9 women obtained follow-up mammograms, with a median density of 5.7%. Vitamin D status was measured for 31 participants at baseline and 13 participants in the following year. Insufficient vitamin D status (<30 ng/mL) was noted in 77% at each time point. Mammographic density was not significantly correlated with vitamin D status ( P = .06). Conclusions: On the basis of this small pilot study, vitamin D insufficiency is common in this study population. Owing to the small sample size, an association between vitamin D insufficiency and breast density was not clear. Additional unexpected findings included substantial barriers in initial access to care and longitudinal follow-up in this population. Further study of these issues is needed.

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