OCT-based strain mapping and compression optical coherence elastography to study and control laser-assisted modification of avascular collagenous tissues

2020 ◽  
Author(s):  
Vladimir Y. Zaitsev ◽  
Alexander L. Matveyev ◽  
Lev A. Matveev ◽  
Alexander A. Sovetsky ◽  
Olga I. Baum ◽  
...  
Keyword(s):  
Optical Coherence ◽  
Strain Mapping ◽  
Collagenous Tissues ◽  
And Control ◽  
Control Laser

scholarly journals Comparison between Widefield Optical Coherence Tomography Devices in Eyes with High Myopia

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 658
Author(s):  
Federico Corvi ◽  
Federico Zicarelli ◽  
Matteo Airaldi ◽  
Salvatore Parrulli ◽  
Mariano Cozzi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Myopia ◽  
Cross Sectional Study ◽  
Horizontal Line ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Image Artifact ◽  
Control Subjects ◽  
And Control

Background: To compare four different optical coherence tomography (OCT) devices for visualization of retinal and subretinal layers in highly myopic eyes. Methods: In this prospective, observational, cross-sectional study, consecutive patients with high myopia and control subjects were imaged by four OCT devices: Spectralis OCT2, PlexElite 2.0 100 kHz, PlexElite 2.0 200 kHz and the Canon Xephilio OCT-S1. The acquisition protocol for comparison consisted of single vertical and horizontal line scans centered on the fovea. Comparison between the devices in the extent of visible retina, presence of conjugate image or mirror artifacts, visibility of the sclerochoroidal interface and retrobulbar tissue. Results: 30 eyes with high myopia and 30 control subjects were analyzed. The visualized RPE length was significantly different between the OCT devices with Xephilio OCT-S1 imaging the largest extent (p < 0.0001). The proportion of eyes with conjugate image artifact was significantly higher with the Spectralis OCT (p < 0.0001), and lower with the PlexElite 200 kHz (p < 0.0001). No difference in visibility of the sclerochoroidal interface was noted among instruments. The retrobulbar tissue was visible in a higher proportion of eyes using swept-source PlexElite 100 kHz and 200 kHz (p < 0.007) compared to the other devices. Conclusions: In highly myopic eyes, the four OCT devices demonstrated significant differences in the extent of the retina imaged, in the prevalence of conjugate image artifact, and in the visualization of the retrobulbar tissue.

scholarly journals Transversal ultrahigh-resolution polarizationsensitive optical coherence tomography for strain mapping in materials

2006 ◽  
Vol 14 (13) ◽  
pp. 5945 ◽  
Author(s):  
K. Wiesauer ◽  
M. Pircher ◽  
E. Goetzinger ◽  
C. K. Hitzenberger ◽  
R. Engelke ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Strain Mapping ◽  
Ultrahigh Resolution

OCT Angiography of the Central Macular Capillary Network in Glaucoma Patients and Healthy Controls

2018 ◽  
Vol 235 (04) ◽  
pp. 436-444
Author(s):  
Olena Müller ◽  
Margarita G. Todorova ◽  
Torsten Schlote
Keyword(s):  
Optical Coherence Tomography ◽  
Structural Changes ◽  
Ganglion Cells ◽  
Retinal Nerve Fibre Layer ◽  
Vessel Density ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Significant Difference ◽  
Nerve Fibre Layer ◽  
And Control

Abstract Purpose We aimed to investigate central macular microvasculature by optical coherence tomography angiography (OCTA) and to analyse its relation to alterations in classical parameters of optical coherence tomography (OCT) in glaucoma patients. Methods Using OCTA (Avanti incl. AngioVue; Optovue, Inc., Fremont, CA), the superficial flow (SF) and the superficial non-flow (SNF) area of the macula, as well as the S-ETDRS (based on Early Treatment Diabetic Retinopathy charts). and S-grid vessel density (zones 1 – 9) of the macula, were evaluated in 27 glaucoma patients (49 eyes) and compared to those of 27 age-matched healthy controls (50 eyes; p = 0.253). The interactions between OCTA parameters representing macular microvasculature and classical OCT measurements of the circumpapillary retinal nerve fibre layer (RNFL) and macular ganglion cells (mGCC) were analysed within groups (linear mixed-effects model). Results SF, SNF, and S-ETDRS vessel density exhibited no significant difference between the glaucoma and control groups (all p ≥ 0.158). However, within the glaucoma group, decreased RNFL and mGCC thickness correlated significantly with decreased S-ETDRS density (zones 1; 2 – 9, p ≤ 0.033). The same held true for the interactions between the RNFL and mGCC thickness with S-grid density (zones 1 – 3; 6 – 9; p ≤ 0.033). For perimetric glaucoma patients, subgroup analyses demonstrated significantly reduced density maps of superficial foveal flow as well as significant interactions between OCT and OCTA parameters; this was not the case within the preperimetric group. Conclusions Even if the central macular microvasculature, as measured by SF and SNF, is found preserved in glaucoma, the strong positive relation between the central microvascular and structural changes in OCTA and OCT indicates that there are alterations in central macular microvasculature in subclinical glaucoma.

Ultra-high resolution, polarization sensitive transversal optical coherence tomography for structural analysis and strain mapping

2006 ◽  
Author(s):  
Karin Wiesauer ◽  
Michael Pircher ◽  
Erich Goetzinger ◽  
Christoph K. Hitzenberger ◽  
Rainer Engelke ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Structural Analysis ◽  
High Resolution ◽  
Optical Coherence ◽  
Strain Mapping

scholarly journals Automated Measurement of Iris Surface Smoothness Using Anterior Segment Optical Coherence Tomography  

2021 ◽  
Author(s):  
Mohammad Zarei ◽  
Tahereh Mahmudi ◽  
Hamid Riazi-Esfahani ◽  
Behnam Mousavi ◽  
Nazanin Ebrahimiadib ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Correlation Coefficient ◽  
Anterior Segment ◽  
Control Group ◽  
Optical Coherence ◽  
Interclass Correlation Coefficient ◽  
Interclass Correlation ◽  
Automated Measurements ◽  
And Control ◽  
Fellow Eyes

Abstract Fuchs uveitis (FU) is a chronic and often unilateral ocular inflammation and characteristic iris atrophic changes, other than heterochromia, are common in FU and are key to the correct diagnosis in many cases. With the advent of anterior segment optical coherence tomography (AS-OCT), some investigators attempted to quantitatively study these atrophic changes; mostly by introducing various methods to measure iris thickness in AS-OCT images. We aimed to present an automated method in a observational case series to measure the smoothness index (SI) of iris surface in AS-OCT images. The ratio of the length of the straight line connecting the most peripheral and central points of the anterior iris border (in nasal and temporal sides) to the actual length of this border on AS-OCT images, was defined as SI. In a uveitis referral center twenty-two eyes of 11 patients with unilateral Fuchs uveitis (FU) (7 female) and 22 eyes of 11 healthy control subjects underwent AS-OCT imaging. Image J and a newly developed MATLAB algorithm were used for manual and automated SI measurements, respectively. Agreement between manual and automated measurements was evaluated with Bland-Altman analysis and interclass correlation coefficient. The inter-eye difference of SI was compared between FU group and control group. Automated mean overall SI was 0.868 ± 0.037 and 0.840 ± 0.039 in FU and healthy fellow eyes, respectively (estimated mean difference = -0.028, 95% CI [-0.038, -0.018], p<0.001). Bland- Altman plots showed good agreement between two methods in both healthy and FU eyes. Interclass correlation coefficient between the manual and automated measurements in the FU and healthy fellow eyes was 0.958 and 0.964, respectively. Inter-eye difference of overall SI was 0.029 ± 0.015 and 0.012 ± 0.008 in FU group and control group, respectively (p=0.01). We concluded that he automated algorithm can rapidly and conveniently measure SI with results comparable to manual method.

Choroidal thickness and vascular density in macular telangiectasia type 2 using enface swept-source optical coherence tomography

2019 ◽  
Vol 103 (11) ◽  
pp. 1584-1589 ◽  
Author(s):  
Jay C Wang ◽  
Inês Laíns ◽  
Patrick Oellers ◽  
Ivana K Kim ◽  
Joan W Miller ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Fundus Photography ◽  
Imaging Features ◽  
Optical Coherence ◽  
Swept Source ◽  
Macular Telangiectasia ◽  
Macular Telangiectasia Type 2 ◽  
And Control

PurposeTo investigate the choroidal thickness (CT) and choroidal vascular densities (CVD) of patients with macular telangiectasia type 2 (MacTel2) and their association with other multimodal imaging features, using swept-source optical coherence tomography (SS-OCT).MethodsProspective, cross-sectional study. Consecutive patients with MacTel2 along with controls without any macular disease were included. Fundus photography, confocal blue reflectance, near-infrared reflectance, autofluorescence, fluorescein angiography, spectral domain OCT and SS-OCT were performed. Images were independently analysed by two graders, and CVD was calculated from binarised en face SS-OCT images. CT was obtained from the SS-OCT platform via built-in automated segmentation. Multilevel mixed-effects models were used for statistical analysis.ResultsThirty-nine eyes of 20 patients with MacTel2 and 29 eyes of 15 control patients were included. Average CT and perifoveal temporal CT did not differ significantly between eyes with MacTel2 and control eyes (p≥0.350), when accounting for confounding factors. Overall and temporal CVD also did not significantly differ between the two groups (p≥0.490).ConclusionCT and CVD did not significantly differ between MacTel2 and control eyes in this study using SS-OCT. Even though MacTel2 may include abnormalities involving the choroid, these are likely minor in comparison to the predominant retinal changes.

99Non-ruptured plaque and platelet-rich thrombi in ST-segment elevation myocardial infarction: new insight into early spontaneous reperfusion

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Chen ◽  
G Z Wang ◽  
Z Liu ◽  
Y H Zhang ◽  
J C Guo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Natural Science ◽  
Plaque Rupture ◽  
Control Group ◽  
P Value ◽  
Optical Coherence ◽  
St Segment Elevation ◽  
Plaque Erosion ◽  
One Year ◽  
And Control

Abstract Objectives To detect the potential mechanism of early spontaneous reperfusion (ESR) in STEMI. Background Early spontaneous reperfusion occurs in around 20% of STEMI and is associated with favorable outcomes. Optical coherence tomography (OCT) is more accurate in detecting subtle morphological details of the culprit lesion. Methods In this prospective study, a total of 107 consecutive patients with STEMI were enrolled from July 2016 to May 2017. Of that total, 21 (19.6%) met the criteria of angiographic ESR (TIMI-3 flow in the initial angiogram). Among those without ESR (TIMI-0 flow in the initial angiogram), 21 patients were assigned into the control group according to propensity score matching with the ESR group. The OCT findings and one-year clinical outcomes were compared between the two groups. Results Although baseline characteristics were comparable, plaque features significantly differed between the ESR and control group (P<0.001), including plaque rupture (23.8% vs. 66.7%), plaque erosion (47.6% vs. 33.3%), calcified nodule (9.5% vs. 0%) and vasospasm (19.1% vs. 0%). Red thrombus (19.1% vs. 85.7%) was far less found whereas white thrombus (61.9% vs. 14.3%) was more common in the ESR group. In addition, despite of less stent placement (0.6±0.5 vs. 1.3±0.9, P<0.001), patients in the ESR group had a non-statistically lower rate of cardiac adverse events (4.8% vs. 14.3%, P=0.269) during one-year follow up. The OCT finding Variables ESR group (n=21) Control group (n=21) P value The OCT imaging <0.001   Plaque erosion 10 (47.6) 7 (33.3)   Plaque rupture 5 (23.8) 14 (66.7)   Calcified nodule 2 (9.5) 0 (0)   Vasospasm 4 (19.1) 0 (0) The Type of Thrombus <0.001   Red thrombus 4 (19.1) 18 (85.7)   White thrombus 13 (61.9) 3 (14.3)   No thrombus (vasospasm) 4 (19.1) 0 (0)   MLA (mm2) 2.7±2.2 2.3±2.4 0.534 Values are n (%), mean ± SD. ESR = early spontaneous reperfusion; MLA = Minimum lumen area; OCT = optical coherence tomography. ESR and control group Conclusions Relief of coronary occlusion induced by non-ruptured plaque and platelet-rich thrombi may be one of the main mechanism underlying early spontaneous reperfusion in STEMI. Acknowledgement/Funding No.81470491 from the National Natural Science Foundation of China and No.7192078 from Beijing Municipal Natural Science Foundation to Dr. Li.

Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy: A Randomized Trial of Photoaged Skin

Dermatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Mette Mogensen ◽  
Kristoffer Hendel ◽  
Vilde Ung ◽  
Emily Wenande ◽  
Katrine Togsverd-Bo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Statistical Significance ◽  
Skin Surface ◽  
Reflectance Confocal Microscopy ◽  
Optical Coherence ◽  
Thulium Laser ◽  
Skin Rejuvenation ◽  
Photoaged Skin ◽  
And Control

<b><i>Background and Objectives:</i></b> Image-guided quantitative and semi-quantitative assessment of skin can potentially evaluate treatment efficacy. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are ideal for this purpose. This study assessed clinically relevant statistical changes in RCM and OCT features in photoaged skin after light and energy-based therapy. <b><i>Methods:</i></b> Novel statistical analyses were performed using OCT and RCM data collected during a previously published trial: a 12-week study of female décolleté skin randomized to four areas treated with thulium laser (L), photodynamic therapy (PDT), combined L-PDT, and control. Eight semi-quantitative RCM scores of photodamage and OCT measurements of skin roughness, blood flow, and epidermal thickness (ET) were evaluated and compared to dermoscopy and clinical skin scores. In statistical analysis, estimated treatment difference (ETD) was calculated. <b><i>Results:</i></b> Twelve women with moderate to severe photodamage were included. RCM and OCT data demonstrated a trend towards rejuvenation of epidermis with increased ET, changes in skin surface, and improved honeycomb pattern in RCM. In angiographic OCT, non-significant changes towards more regular capillary meshes were shown, which matched a decline in appearance of gross telangiectasias in dermoscopy. Improved skin tone after laser and L-PDT was identified in RCM, showing less edged papillae in 36% and 45%, and lentigo number declined in 55% of patients after treatments in dermoscopy. Based on clinical scores, L-PDT provided the greatest clinical improvement, which corresponded to superior ETD outcomes in ET and edged papillae shown in OCT and RCM, respectively. <b><i>Conclusion:</i></b> Objective OCT and RCM assessment of skin rejuvenation was demonstrated in this study. Importantly, image-based improvements corresponded to favorable clinical skin scores and fewer photoaging characteristics in dermoscopy. Importantly, most changes did not reach statistical significance, prompting further studies and emphasizing the modest value of non-randomized, non-blinded anti-aging trials.

Sign in / Sign up

Export Citation Format

Share Document