Deep learning-based automated hot-spot detection and tumor grading in human gastrointestinal neuroendocrine tumor

Author(s):  
Darshana Govind ◽  
Kuang-Yu Jen ◽  
Pinaki Sarder
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Darshana Govind ◽  
Kuang-Yu Jen ◽  
Karen Matsukuma ◽  
Guofeng Gao ◽  
Kristin A. Olson ◽  
...  

2020 ◽  
Vol 1693 ◽  
pp. 012075
Author(s):  
Yifeng Ren ◽  
Yongjun Yu ◽  
Jing Li ◽  
Wenhua Zhang

2021 ◽  
Vol 13 (10) ◽  
pp. 1909
Author(s):  
Jiahuan Jiang ◽  
Xiongjun Fu ◽  
Rui Qin ◽  
Xiaoyan Wang ◽  
Zhifeng Ma

Synthetic Aperture Radar (SAR) has become one of the important technical means of marine monitoring in the field of remote sensing due to its all-day, all-weather advantage. National territorial waters to achieve ship monitoring is conducive to national maritime law enforcement, implementation of maritime traffic control, and maintenance of national maritime security, so ship detection has been a hot spot and focus of research. After the development from traditional detection methods to deep learning combined methods, most of the research always based on the evolving Graphics Processing Unit (GPU) computing power to propose more complex and computationally intensive strategies, while in the process of transplanting optical image detection ignored the low signal-to-noise ratio, low resolution, single-channel and other characteristics brought by the SAR image imaging principle. Constantly pursuing detection accuracy while ignoring the detection speed and the ultimate application of the algorithm, almost all algorithms rely on powerful clustered desktop GPUs, which cannot be implemented on the frontline of marine monitoring to cope with the changing realities. To address these issues, this paper proposes a multi-channel fusion SAR image processing method that makes full use of image information and the network’s ability to extract features; it is also based on the latest You Only Look Once version 4 (YOLO-V4) deep learning framework for modeling architecture and training models. The YOLO-V4-light network was tailored for real-time and implementation, significantly reducing the model size, detection time, number of computational parameters, and memory consumption, and refining the network for three-channel images to compensate for the loss of accuracy due to light-weighting. The test experiments were completed entirely on a portable computer and achieved an Average Precision (AP) of 90.37% on the SAR Ship Detection Dataset (SSDD), simplifying the model while ensuring a lead over most existing methods. The YOLO-V4-lightship detection algorithm proposed in this paper has great practical application in maritime safety monitoring and emergency rescue.


Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2866
Author(s):  
Fernando Navarro ◽  
Hendrik Dapper ◽  
Rebecca Asadpour ◽  
Carolin Knebel ◽  
Matthew B. Spraker ◽  
...  

Background: In patients with soft-tissue sarcomas, tumor grading constitutes a decisive factor to determine the best treatment decision. Tumor grading is obtained by pathological work-up after focal biopsies. Deep learning (DL)-based imaging analysis may pose an alternative way to characterize STS tissue. In this work, we sought to non-invasively differentiate tumor grading into low-grade (G1) and high-grade (G2/G3) STS using DL techniques based on MR-imaging. Methods: Contrast-enhanced T1-weighted fat-saturated (T1FSGd) MRI sequences and fat-saturated T2-weighted (T2FS) sequences were collected from two independent retrospective cohorts (training: 148 patients, testing: 158 patients). Tumor grading was determined following the French Federation of Cancer Centers Sarcoma Group in pre-therapeutic biopsies. DL models were developed using transfer learning based on the DenseNet 161 architecture. Results: The T1FSGd and T2FS-based DL models achieved area under the receiver operator characteristic curve (AUC) values of 0.75 and 0.76 on the test cohort, respectively. T1FSGd achieved the best F1-score of all models (0.90). The T2FS-based DL model was able to significantly risk-stratify for overall survival. Attention maps revealed relevant features within the tumor volume and in border regions. Conclusions: MRI-based DL models are capable of predicting tumor grading with good reproducibility in external validation.


Author(s):  
Rami F. Salem ◽  
Ahmed Arafa ◽  
Sherif Hany ◽  
Abdelrahman ElMously ◽  
Haitham Eissa ◽  
...  

Author(s):  
Francesco Lancellotti ◽  
Luigi Solinas ◽  
Davide Telesco ◽  
Andrea Sagnotta ◽  
Augusto Belardi ◽  
...  

Abstract Gastrointestinal neuroendocrine tumor (NET) associated with a metachronous intestinal adenocarcinoma is rare. We report the case of a 71-year-old man with an ileal NET. Patient has previously undergone a left colectomy for sigmoid cancer. We report a complete review both of the metachronous and synchronous NET. A comprehensive systematic literature search in PubMed, EMBASE, and MEDLINE identified a total of 35 relevant studies. This study includes an analysis of review articles, case reports, case series, retrospective studies and population-based studies. In the English literature to date, there are 21 case reports (19 synchronous cases and 2 metachronous cases), 3 case series and 3 review articles, and less than 10 retrospective studies or population-based studies. A total of 31 patients in 24 articles were included in the study: 28 patients with a synchronous gastrointestinal NET and colorectal adenocarcinoma and 3 patients with metachronous gastrointestinal NET and colorectal adenocarcinoma. The incidence of synchronous cancer (particularly for colorectal and gastric cancer) with a gastrointestinal NET ranges from 10 to 50%, while for the metachronous ones it is still unclear. This is the third metachronous case report and the first descriptive case of gastrointestinal NET diagnosed 2 years after a colorectal adenocarcinoma. An endoscopic follow-up program for gastrointestinal NET patients and/or for first-degree relatives of NET patients appears recommendable.


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