Developing a low cost image marker to identify lymph node metastasis for cervical cancer patients: an initial study

2020 ◽  
Author(s):  
Wei Liu ◽  
Shiyu Pei ◽  
Xuxin Chen ◽  
Theresa Thai ◽  
Tara Castellano ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Low Cost ◽  
Initial Study ◽  
Node Metastasis

scholarly journals Sentinel Lymph Node Biopsy Is Feasible in Cervical Cancer Laparoscopic Surgery: A Single-Center Retrospective Cohort Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hongyi Hou ◽  
Yibo Dai ◽  
Sichen Liang ◽  
Zhiqi Wang ◽  
Jianliu Wang
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Laparoscopic Surgery ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Clinical Application ◽  
Related Factors ◽  
Detection Rates ◽  
Node Metastasis

Background and Objective. Sentinel lymph node (SLN) biopsy efficiency has been confirmed in various solid tumors. This study aimed to assess SLN biopsy feasibility in clinical application and explore how to improve its detection rates and diagnostic accuracy in cervical cancer laparoscopic surgery. Methods. A total of 100 cervical cancer patients undergoing laparoscopic surgery with SLN biopsy were included. Indocyanine green, carbon nanoparticles (CNPs), and a combination of both were used during surgeries. Detection rates, sensitivity, negative predictive value (NPV) of SLN biopsy, and related factors were analyzed. Results. The overall and bilateral SLN detection rates were 92% (92/100) and 74% (74/100), respectively. Combined tracers had higher bilateral SLN detection rates than CNPs alone ( p = 0.005 ). Menopause and lymph node metastasis were associated with lower overall and bilateral SLN detection rates ( p < 0.05 ). SLN biopsy sensitivity and NPV for lymph node metastasis in patients with at least one detected SLN were 81.8% (9/11) and 97.3% (72/74), respectively. Among those with bilateral detected SLNs, higher sensitivity and NPV of 87.5% (7/8) and 98.3% (57/58) were observed, respectively. SLN algorithm can ensure that all patients with lymph node metastasis are detected by SLN biopsy. Conclusion. SLN biopsy appears to be safe and effective for specific cervical cancer patients with high detection rates and NPV in laparoscopic surgery, especially for those with detected bilateral SLNs and undergoing the SLN algorithm. Selecting suitable patients for SLN mapping has prospects for clinical application.

Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study

2017 ◽  
Vol 24 (8) ◽  
pp. 2311-2318 ◽  
Author(s):  
Gabriella Ferrandina ◽  
Luigi Pedone Anchora ◽  
Valerio Gallotta ◽  
Anna Fagotti ◽  
Enrico Vizza ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Retrospective Study ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Large Scale ◽  
Early Stage ◽  
Node Metastasis ◽  
Early Stage Cervical Cancer

scholarly journals Developing a new radiomics-based CT image marker to detect lymph node metastasis among cervical cancer patients

2020 ◽  
Vol 197 ◽  
pp. 105759
Author(s):  
Xuxin Chen ◽  
Wei Liu ◽  
Theresa C. Thai ◽  
Tara Castellano ◽  
Camille C. Gunderson ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Ct Image ◽  
Node Metastasis ◽  
Detect Lymph Node Metastasis

Predicting tumor recurrence in patients with cervical carcinoma treated with definitive chemoradiotherapy: value of quantitative histogram analysis on diffusion-weighted MR images

2016 ◽  
Vol 58 (4) ◽  
pp. 481-488 ◽  
Author(s):  
Gurcan Erbay ◽  
Cem Onal ◽  
Elif Karadeli ◽  
Ozan C Guler ◽  
Sami Arica ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Tumor Recurrence ◽  
Disease Recurrence ◽  
Definitive Chemoradiotherapy ◽  
Node Metastasis ◽  
The Mean

Background Further research is required for evaluating the use of ADC histogram analysis in more advanced stages of cervical cancer treated with definitive chemoradiotherapy (CRT). Purpose To investigate the utility of apparent diffusion coefficient (ADC) histogram derived from diffusion-weighted magnetic resonance images in cervical cancer patients treated with definitive CRT. Material and Methods The clinical and radiological data of 50 patients with histologically proven cervical squamous cell carcinoma treated with definitive CRT were retrospectively analyzed. The impact of clinicopathological factors and ADC histogram parameters on prognostic factors and treatment outcomes was assessed. Results The mean and median ADC values for the cohort were 1.043 ± 0.135 × 10−3 mm2/s and 1.018 × 10−3 mm2/s (range, 0.787–1.443 × 10−3 mm2/s). The mean ADC was significantly lower for patients with advanced stage (≥IIB) or lymph node metastasis compared with patients with stage <IIB or no lymph node metastasis. The mean ADC, 75th percentile ADC (ADC75), 90th percentile ADC (ADC90), and 95th percentile ADC (ADC95) were significantly lower in patients with tumor recurrence compared with patients without recurrence. In multivariate analysis, tumor size, ADC75 and ADC95 were independent prognostic factors for both overall survival and disease-free survival. Conclusion ADC histogram parameters could be markers for disease recurrence and for predicting survival outcomes. ADC75, ADC90, and ADC95 of the primary tumor were significant predictors of disease recurrence in cervical cancer patients treated with definitive CRT.

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