scholarly journals Hyperspectral imaging and deep learning for the detection of breast cancer cells in digitized histological images

Author(s):  
Samuel Ortega ◽  
Martin Halicek ◽  
Himar Fabelo ◽  
Raul Guerra ◽  
Carlos Lopez ◽  
...  
Author(s):  
Md. Ashiqul Islam ◽  
Dhonita Tripura ◽  
Mithun Dutta ◽  
Md. Nymur Rahman Shuvo ◽  
Wasik Ahmmed Fahim ◽  
...  

Author(s):  
Ting Chean Khoo ◽  
Kate Tubbesing ◽  
Alena Rudkouskaya ◽  
Georgios A. Athanassiadis ◽  
Anna V. Sharikova ◽  
...  

2021 ◽  
Author(s):  
Golnaz Moallem ◽  
Adity A. Pore ◽  
Anirudh Gangadhar ◽  
Hamed Sari-Sarraf ◽  
Siva A Vanapalli

Significance: Circulating tumor cells (CTCs) are important biomarkers for cancer management. Isolated CTCs from blood are stained to detect and enumerate CTCs. However, the staining process is laborious and moreover makes CTCs unsuitable for drug testing and molecular characterization. Aim: The goal is to develop and test deep learning (DL) approaches to detect unstained breast cancer cells in bright field microscopy images that contain white blood cells (WBCs). Approach: We tested two convolutional neural network (CNN) approaches. The first approach allows investigation of the prominent features extracted by CNN to discriminate cancer cells from WBCs. The second approach is based on Faster Region-based Convolutional Neural Network (Faster R-CNN). Results: Both approaches detected cancer cells with high sensitivity and specificity with the Faster R-CNN being more efficient and suitable for deployment. The distinctive feature used by the CNN used to discriminate is cell size, however, in the absence of size difference, the CNN was found to be capable of learning other features. The Faster R-CNN was found to be robust with respect to intensity and contrast image transformations. Conclusions: CNN-based deep learning approaches could be potentially applied to detect patient-derived CTCs from images of blood samples.


2020 ◽  
Vol 11 (6) ◽  
pp. 2976
Author(s):  
Sangyeon Youn ◽  
Kyungsu Lee ◽  
Jeehoon Son ◽  
In-Hwan Yang ◽  
Jae Youn Hwang

2010 ◽  
Vol 34 (8) ◽  
pp. S49-S49
Author(s):  
Lei Wang ◽  
Xun Zhou ◽  
Lihong Zhou ◽  
Yong Chen ◽  
Xun Zhu ◽  
...  

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