Assessment of toxin-induced airway injury and therapeutic effects in a rat model by optical coherence tomography

2020 ◽  
Author(s):  
Ryan Cheung ◽  
Yusi Miao ◽  
Andy Choi ◽  
Carl W. White ◽  
Matthew Brenner ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Rat Model ◽  
Therapeutic Effects ◽  
Optical Coherence ◽  
Airway Injury

scholarly journals In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography

2009 ◽  
Vol 14 (6) ◽  
pp. 060503 ◽  
Author(s):  
Jiechen Yin ◽  
Gangjun Liu ◽  
Jun Zhang ◽  
Lingfeng Yu ◽  
Sari Mahon ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Early Detection ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Swept Source ◽  
Airway Injury

scholarly journals Optical Coherence Tomography to Monitor Rebound Intracranial Hypertension with Increased Papilledema after Lumbar Puncture

NeuroSci ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 334-338
Author(s):  
Yumin Huang-Link ◽  
Pierfrancesco Mirabelli ◽  
Ge Yang ◽  
Andreas Eleftheriou ◽  
Hans Link
Keyword(s):  
Optical Coherence Tomography ◽  
Intracranial Hypertension ◽  
Lumbar Puncture ◽  
Clinical Decision Making ◽  
Response To Therapy ◽  
Therapeutic Effects ◽  
Optical Coherence ◽  
Visual Dysfunction ◽  
Csf Pressure ◽  
Rnfl Thickness

Objective: We report that lumbar puncture (LP) with removal of cerebrospinal fluid (CSF) induced rebound intracranial hypertension with increased papilledema as monitored by optical coherence tomography (OCT). Background: Severe papilledema causes visual field loss and central vision damage if untreated. Fundoscopy is a key to diagnose papilledema, but is not sensitive enough to monitor therapeutic effects. Methods: OCT was applied to follow a 24-year-old woman with headache, visual dysfunction, severe bilateral papilledema, and elevated CSF opening pressure. She was first treated with serial LP, which led to symptom deterioration, increased CSF pressure, and increased the retinal nerve fiber layer (RNFL) thickness. She was then successfully treated with acetazolamide and furosemide. Results: OCT showed reduction of RNFL thickness directly after LP with CSF removal, accompanied with reduced CSF pressure. Increased RNFL thickness accompanied with worsened headache, visual dysfunction, and increased CSF pressure was observed on the next day after LP. Less than 24 h after start of medication, the symptoms had reversed and RNFL thickness was reduced. The patient was symptom-free 2 weeks after starting on medical treatment. Papilledema had vanished on fundoscopy 6 weeks after the therapy, and RNFL thickness was normalized at 3 months of follow-up. Conclusion: This case provides evidence that OCT is an objective and sensitive tool to monitor papilledema and its response to therapy, and thereby important to help in correct clinical decision-making.

scholarly journals Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography

2009 ◽  
Vol 14 (4) ◽  
pp. 044037 ◽  
Author(s):  
Kelly A. Kreuter ◽  
Sari B. Mahon ◽  
David S. Mukai ◽  
Jianping Su ◽  
Woong-Gyu Jung ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Resolution ◽  
Optical Coherence ◽  
Airway Injury
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