Development of a compact multimodal imaging system for rapid characterisation of intrinsic optical properties of freshly excised tissue (Conference Presentation)

2020 ◽  
Author(s):  
Jonghee Yoon ◽  
Abby Wilson ◽  
Dale J. Waterhouse ◽  
Travis W. Sawyer ◽  
Massimiliano di Pietro ◽  
...  
Keyword(s):  
Optical Properties ◽  
Multimodal Imaging ◽  
Imaging System ◽  
Excised Tissue

scholarly journals Multimodal imaging system for dental caries detection

2007 ◽  
Author(s):  
Rongguang Liang ◽  
Victor Wong ◽  
Michael Marcus ◽  
Peter Burns ◽  
Paul McLaughlin
Keyword(s):  
Dental Caries ◽  
Multimodal Imaging ◽  
Imaging System ◽  
Caries Detection

Measuring the retina optical properties using a structured illumination imaging system

2011 ◽  
Author(s):  
A. Basiri ◽  
T. A. Nguyen ◽  
M. Ibrahim ◽  
Q. D. Nguyen ◽  
Jessica C. Ramella-Roman
Keyword(s):  
Optical Properties ◽  
Imaging System ◽  
Structured Illumination

scholarly journals Double-Clad Optical Fiber-Based Multi-Contrast Noncontact Photoacoustic and Fluorescence Imaging System

Electronics ◽  
2021 ◽  
Vol 10 (23) ◽  
pp. 3008
Author(s):  
Jun Geun Shin ◽  
Jonghyun Eom
Keyword(s):  
Fluorescence Imaging ◽  
Multimodal Imaging ◽  
Imaging System ◽  
Imaging Technique ◽  
Photoacoustic Imaging ◽  
Imaging Systems ◽  
Complementary Information ◽  
Imaging Results ◽  
Fluorescence Imaging System ◽  
Fluorescence Images

A noncontact photoacoustic and fluorescence dual-modality imaging system is proposed, which integrates a fiber-based fluorescence imaging system with noncontact photoacoustic imaging using a specially fabricated double-cladding fiber (DCF) coupler and a DCF lens. The performance of the DCF coupler and lens was evaluated, and the feasibility of this new imaging system was demonstrated using simple tubing phantoms with black ink and fluorophore. Our imaging results demonstrated that the multimodal imaging technique can simultaneously acquire photoacoustic and fluorescence images without coming into contact with the sample. Consequently, the developed method is the first noncontact scheme among multimodal imaging systems that is integrated with a photoacoustic imaging system, which can provide varied and complementary information about the sample.

scholarly journals Integrating photoacoustic microscopy, optical coherence tomography, OCT angiography, and fluorescence microscopy for multimodal imaging

2020 ◽  
Vol 245 (4) ◽  
pp. 342-347 ◽  
Author(s):  
Arash Dadkhah ◽  
Shuliang Jiao
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescence Microscopy ◽  
Multimodal Imaging ◽  
Imaging System ◽  
Optical Resolution ◽  
Biological Tissues ◽  
Large Field ◽  
Optical Coherence ◽  
Photoacoustic Microscopy

We have developed a multimodal imaging system, which integrated optical resolution photoacoustic microscopy, optical coherence tomography, optical coherence tomography angiography, and confocal fluorescence microscopy in one platform. The system is able to image complementary features of a biological sample by combining different contrast mechanisms. We achieved fast imaging and large field of view by combining optical scanning with mechanical scanning, similar to our previous publication. We have demonstrated the capability of the multimodal imaging system by imaging a mouse ear in vivo. Impact statement Photoacoustic microscopy-based multimodal imaging technology can provide high-resolution complementary information for biological tissues in vivo. It will potentially bring significant impact on the research and diagnosis of diseases by providing combined structural and functional information.

Verification of Long-Range MTF Testing Through Intermediary Optics

2020 ◽  
Vol 2020 (9) ◽  
pp. 346-1-346-7
Author(s):  
Alexander Schwartz ◽  
Sarthak Tandon ◽  
Jackson Knappen
Keyword(s):  
Optical Properties ◽  
Long Range ◽  
Real World ◽  
Imaging System ◽  
Imaging Systems ◽  
Depth Of Field ◽  
Use Case ◽  
Production Environment ◽  
Simulated Test ◽  
Working Distance

Measuring the MTF of an imaging system at its operational working distance is useful for understanding the system’s use case performance. However, it is often not practical to test imaging systems at long distances (several meters to infinity), particularly in a production environment. Intermediate optics (relay lenses) can be used to simulate longer test distances. The Imatest Collimator Fixture is a machine developed for testing imaging systems at specified simulated distances up to infinity through the use of a relay lens and a test chart. The relay lens’s optical properties dictate the required distance between the optic and the test chart, or Collimator Working Distance (WDC), to project the correct simulated distance (SD). This paper provides a method for validating the accuracy of simulated test distances. Successful validation is achieved when the distances at which peak MTF occurs in the real world match the simulated distances at which peak MTF occurs on the collimator fixture, or if both distances are within the depth of field (DoF) of the imaging system in use.

A coregistered multimodal imaging system for reflectance, multiphoton, and optical coherence microscopy

2021 ◽  
Author(s):  
David Vega ◽  
Jennifer K. Barton ◽  
Dominique B. Galvez ◽  
Steven P. Santaniello ◽  
Zuzana Adams ◽  
...  
Keyword(s):  
Multimodal Imaging ◽  
Imaging System ◽  
Optical Coherence ◽  
Optical Coherence Microscopy

Time-resolved imaging of fluorescent inclusions in optically turbid medium — phantom study

2010 ◽  
Vol 18 (1) ◽  
Author(s):  
M. Kacprzak ◽  
A. Liebert ◽  
P. Sawosz ◽  
N. Żołek ◽  
D. Milej ◽  
...  
Keyword(s):  
Optical Properties ◽  
Imaging System ◽  
Single Photon ◽  
Photon Counting ◽  
Turbid Medium ◽  
Time Resolved ◽  
Excitation Light ◽  
Time Resolved Imaging ◽  
Fish Tank ◽  
Surrounding Liquid

AbstractWe present results of application of a time-resolved optical system for imaging of fluorescence excited in an inclusion containing indocyanine green (ICG), and located in optically turbid medium. The developed imaging system enabled simultaneous acquisition of fluorescence and diffusive reflectance. Eight independent time-resolved measurement channels based on time-correlated single photon counting technique were applied. In four of these channels, used for the fluorescence detection, sets of filters were applied in order to block the excitation light. Fast optomechanical switches allowed us to illuminate sequentially nine different spots on the surface of the studied object and finally 4×4 pixels maps at excitation and emission wavelengths were obtained. A liquid phantom used in this study consists of the fish tank filed with a solution ofmilk and water with black ink added to obtain optical properties in the range of the optical properties typical for the living tissue. A gel ball of a diameter of 5 mm with precisely controlled concentration of ICG was immersed in the liquid. The measurements were performed for inclusion located at different depths and for various ICG concentrations in the gel ball and in the surrounding liquid. The recorded distributions of times of arrival (DTA) of fluorescence photons and times of flight (DTOF) of diffusely reflected photons were analyzed by calculation of their statistical moments. We observed specific changes in moments of the measured DTAs as a function of depth of immersion of the fluorescent inclusion in the medium. We noted also that the changes of moments depend significantly on concentration of the dye in the fluorescence inclusion as well as in the surrounding liquid.

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