Ultra-high-speed wide-field photoacoustic microscopy using a polygon mirror scanner (Conference Presentation)

2020 ◽  
Author(s):  
Junjie Yao ◽  
Bangxin Lan ◽  
Wei Liu ◽  
Qifa Zhou ◽  
Jun Zou ◽  
...  
Keyword(s):  
High Speed ◽  
Wide Field ◽  
Photoacoustic Microscopy ◽  
Ultra High Speed

High-speed wide-field photoacoustic microscopy with enhanced sensitivity

2021 ◽  
Author(s):  
Hyojin Kim ◽  
Jin Young Kim ◽  
Jinwoo Baik ◽  
Seonghee Cho ◽  
Chulhong Kim
Keyword(s):  
High Speed ◽  
Wide Field ◽  
Photoacoustic Microscopy ◽  
Enhanced Sensitivity

scholarly journals Ultra-high-speed multi-parametric photoacoustic microscopy

2021 ◽  
Author(s):  
Song Hu ◽  
Fenghe Zhong
Keyword(s):  
High Speed ◽  
Laser Scanning ◽  
Ultrasonic Transducer ◽  
Hemoglobin Concentration ◽  
Blood Oxygenation ◽  
Flow Quantification ◽  
Photoacoustic Microscopy ◽  
Ultra High Speed ◽  
Working Distance

Multi-parametric photoacoustic microscopy (PAM) is uniquely capable of simultaneous, high-resolution mapping of blood hemoglobin concentration, oxygenation, and flow in vivo. However, its speed has been limited by the dense sampling required for blood flow quantification. To overcome this limitation, we have developed an ultra-high-speed multi-parametric PAM system, which enables simultaneous acquisition of ~500 densely sampled B-scans by superposing the rapid laser scanning across the line-shaped focus of a cylindrically focused ultrasonic transducer over the conventional mechanical scan of the optical-acoustic dual foci. A novel optical-acoustic combiner is designed and implemented to accommodate the short working distance of the transducer, enabling convenient confocal alignment of the dual foci in the reflection mode. This new system enables continuous monitoring of microvascular hemoglobin concentration, blood oxygenation, and flow over a 4.5 x 3 mm2 area in the awake mouse brain with high spatial and temporal resolution (6.9 μm and 0.3 Hz, respectively).

scholarly journals High-speed wide-field multi-parametric photoacoustic microscopy

2020 ◽  
Vol 45 (10) ◽  
pp. 2756 ◽  
Author(s):  
Fenghe Zhong ◽  
Youwei Bao ◽  
Ruimin Chen ◽  
Qifa Zhou ◽  
Song Hu
Keyword(s):  
High Speed ◽  
Wide Field ◽  
Photoacoustic Microscopy

scholarly journals Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy

2022 ◽  
Author(s):  
Junjie Yao ◽  
Xiaoyi Zhu ◽  
Qiang Huang ◽  
Anthony DiSpirito ◽  
Tri Vu ◽  
...  
Keyword(s):  
Real Time ◽  
Oxygen Delivery ◽  
High Speed ◽  
Brain Research ◽  
High Sensitivity ◽  
Wide Field ◽  
Photoacoustic Microscopy ◽  
Whole Brain ◽  
Functional Changes ◽  
Brain Hemodynamics

Abstract High-speed high-resolution imaging of the whole-brain hemodynamics is urgently needed to facilitate the next level of neurovascular research. Image acquisition speed and image quality are crucial to visualizing real-time hemodynamics in complex brain vascular networks, and displaying fast pathophysiological dynamics on a micro and macro-level, enabling advances in current queries in neurovascular and brain metabolism research, including stroke, dementia and acute brain injury. Further, real-time oxygen saturation of hemoglobin (sO2) imaging to differentiate arteries from veins and capture fast-paced oxygen delivery dynamics is needed to solve pertinent questions in these fields and beyond. Here, we present a novel ultrafast functional photoacoustic microscopy (UFF-PAM) to image the whole-brain hemodynamics and oxygen delivery. UFF-PAM takes advantage of several key engineering innovations, including Raman-shifter-based dual-wavelength laser excitation, water-immersible 12-facet-polygon scanner, high-sensitivity ultrasound transducer, and deep-learning-based image upsampling. A volumetric imaging rate of 2 Hz has been achieved over a field of view (FOV) of 11× 7.5 × 1.5 mm3 with a high spatial resolution of ~10 µm. Using the UFF-PAM system, we have demonstrated proof-of-concept functional studies on the mouse brains in response to systemic hypoxia, sodium nitroprusside, and stroke. We observed the mouse brain’s fast morphological and functional changes over the entire cortex, including vasoconstriction, vasodilation, and deoxygenation. More interestingly, for the first time, under the whole-brain FOV and micro-vessel resolution, we captured the vasoconstriction and oxygenation change simultaneously in the spreading depolarization (SD) wave. Our work provides a great potential for fundamental brain research under various pathological and physiological conditions.

Recent Advances in Ultra-High-Speed Waveguide Photodiodes for Optical Communication Systems

2009 ◽  
Vol E92-C (7) ◽  
pp. 922-928 ◽  
Author(s):  
Kikuo MAKITA ◽  
Kazuhiro SHIBA ◽  
Takeshi NAKATA ◽  
Emiko MIZUKI ◽  
Sawaki WATANABE
Keyword(s):  
Optical Communication ◽  
Communication Systems ◽  
High Speed ◽  
Recent Advances ◽  
Ultra High Speed ◽  
Optical Communication Systems

Interior Winding Synchronous Motor for Reducing Iron Loss at Ultra-High-Speed

2020 ◽  
Author(s):  
Ryoken Masuda ◽  
Manabu Horiuchi ◽  
Mitsuhide Sato ◽  
Yinggang Bu ◽  
Masami Nirei ◽  
...  
Keyword(s):  
High Speed ◽  
Synchronous Motor ◽  
Iron Loss ◽  
Ultra High Speed
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