scholarly journals Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging

2020 ◽  
Author(s):  
Judith olde Heuvel ◽  
Berlinda de Wit-van der Veen ◽  
Henk G. van der Poel ◽  
Marcel Stokkel ◽  
Cornelis Slump
Keyword(s):  
Prostate Cancer ◽  
Cancer Surgery ◽  
Luminescence Imaging ◽  
Cerenkov Luminescence Imaging

scholarly journals Cerenkov Luminescence Imaging in prostate cancer: not the only light that shines

2021 ◽  
pp. jnumed.120.260034
Author(s):  
Judith olde Heuvel ◽  
Berlinda Jantina de Wit - van der Veen ◽  
Henk G. van der Poel ◽  
Pim J. van Leeuwen ◽  
Elise M. Bekers ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Luminescence Imaging ◽  
Cerenkov Luminescence Imaging

scholarly journals Cerenkov luminescence imaging (CLI) for image-guided cancer surgery

2016 ◽  
Vol 4 (5) ◽  
pp. 353-366 ◽  
Author(s):  
M. R. Grootendorst ◽  
M. Cariati ◽  
A. Kothari ◽  
D. S. Tuch ◽  
A. Purushotham
Keyword(s):  
Cancer Surgery ◽  
Luminescence Imaging ◽  
Image Guided ◽  
Cerenkov Luminescence Imaging

scholarly journals 68Ga-PSMA Cerenkov luminescence imaging in primary prostate cancer: first-in-man series

2020 ◽  
Vol 47 (11) ◽  
pp. 2624-2632 ◽  
Author(s):  
Judith olde Heuvel ◽  
Berlinda J. de Wit-van der Veen ◽  
Henk G. van der Poel ◽  
Elise M. Bekers ◽  
Maarten R. Grootendorst ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ex Vivo ◽  
Surgical Margin ◽  
Ongoing Study ◽  
Positive Surgical Margin ◽  
Margin Assessment ◽  
Luminescence Imaging ◽  
Cerenkov Luminescence Imaging ◽  
Primary Prostate Cancer ◽  
Intraoperative Margin Assessment

Abstract Purpose Currently, approximately 11–38% of prostate cancer (PCa) patients undergoing radical prostatectomy have a positive surgical margin (PSM) on histopathology. Cerenkov luminescence imaging (CLI) using 68Ga-prostate-specific membrane antigen (68Ga-PSMA) is a novel technique for intraoperative margin assessment. The aim of this first-in-man study was to investigate the feasibility of intraoperative 68Ga-PSMA CLI. In this study, feasibility was defined as the ability to distinguish between a positive and negative surgical margin, imaging within 45 min and low radiation exposure to staff. Methods Six patients were included in this ongoing study. Following perioperative i.v. injection of ~ 100 MBq 68Ga-PSMA, the prostate was excised and immediately imaged ex vivo. Different acquisition protocols were tested, and hotspots on CLI images from the intact prostate were marked for comparison with histopathology. Results By using an acquisition protocol with 150 s exposure time, 8 × 8 binning and a 550 nm shortpass filter, PSMs and negative surgical margins (NSMs) were visually correctly identified on CLI in 3 of the 5 patients. Two patients had a hotspot on CLI from cancer < 0.1 mm from the excision margin. Conclusion Overall, the study showed that 68Ga-PSMA CLI is a feasible and low-risk technique for intraoperative margin assessment in PCa. The remaining patients in this ongoing study will be used to assess the diagnostic accuracy of the technique. Trial registration: NL8256 registered at www.trialregister.nl on 04/11/20109.

scholarly journals Association between PSA values and surveillance quality after prostate cancer surgery

2019 ◽  
Vol 8 (18) ◽  
pp. 7903-7912
Author(s):  
Christina Hunter Chapman ◽  
Megan E. V. Caram ◽  
Archana Radhakrishnan ◽  
Alexander Tsodikov ◽  
Curtiland Deville ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Surgery

scholarly journals Quantitative Measurement of the Thyroid Uptake Function of Mouse by Cerenkov Luminescence Imaging

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chien-Chih Ke ◽  
Zi-Ming He ◽  
Ya-Ju Hsieh ◽  
Chia-Wen Huang ◽  
Jia-Je Li ◽  
...  
Keyword(s):  
Quantitative Measurement ◽  
Luminescence Imaging ◽  
Cerenkov Luminescence Imaging ◽  
Thyroid Uptake

Radical prostate cancer surgery rate quadruples

The Lancet ◽  
1996 ◽  
Vol 348 (9019) ◽  
pp. 48 ◽  
Author(s):  
Mark Quinn
Keyword(s):  
Prostate Cancer ◽  
Cancer Surgery
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