Advanced Thin Ionization Calorimeter (ATIC) balloon experiment: expected performance

1996 ◽  
Author(s):  
Eun-Suk Seo ◽  
James H. Adams, Jr. ◽  
G. L. Bashindzhagyan ◽  
Oleksy V. Dudnik ◽  
Ali R. Fazely ◽  
...  
Keyword(s):  
Expected Performance ◽  
Balloon Experiment ◽  
Ionization Calorimeter

Advanced Thin Ionization Calorimeter (ATIC) balloon experiment: instrumentation

1996 ◽  
Author(s):  
T. Gregory Guzik ◽  
James H. Adams, Jr. ◽  
G. L. Bashindzhagyan ◽  
Oleksy V. Dudnik ◽  
Steven B. Ellison ◽  
...  
Keyword(s):  
Balloon Experiment ◽  
Ionization Calorimeter

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Multi- and In-Stabilities in Gas Partitioning Between Nanoporous Materials and Rubber Balloons

2018 ◽  
Author(s):  
Cory Simon ◽  
carlo carraro
Keyword(s):  
Thermodynamic Equilibrium ◽  
Stable States ◽  
Temperature Changes ◽  
Adsorbed Gas ◽  
Rubber Balloon ◽  
Balloon Size ◽  
Metal Organic ◽  
Balloon Experiment ◽  
Adsorbent System ◽  
Balloon System

<div>In the two-balloon experiment, two rubber balloons are connected and allowed to exchange gas. Owing to the non-monotonic relationship between the radius of the balloon and the pressure of gas inside of it, the two-balloon system presents multi- and in-stabilities.</div><div><br></div><div>Herein, we consider a two-adsorbent system, where two different adsorbents are allowed to exchange gas. We show that, for rigid adsorbents, the thermodynamic equilibrium state is unique.</div><div><br></div><div>Then, we consider an adsorbent-balloon system, where an adsorbent exchanges gas with a rubber balloon. This system can exhibit multiple states at thermodynamic equilibrium-- two (meta)stable and one unstable. The size of the balloon, pressure of gas in the balloon, and partitioning of gas between the adsorbent and the balloon differ among the equilibrium states. Temperature changes and the addition/removal of gas into/from the adsorbent-balloon system can induce catastrophe bifurcations and show hysteresis. Furthermore, the adsorbent-balloon system exhibits a critical temperature where, when approached from below, the discrepancy of balloon size between the two (meta)stable states decreases and, beyond, bistability is impossible.</div><div><br></div><div>Practically, our findings preclude multiple partitions of adsorbed gas in rigid mixed-linker metal-organic frameworks and may inspire new soft actuator and sensor designs.</div>

Polar patrol balloon experiment in Antarctica

1993 ◽  
Vol 13 (2) ◽  
pp. 127-130 ◽  
Author(s):  
M. Ejiri ◽  
A. Kadokura ◽  
T. Hirasawa ◽  
N. Sato ◽  
R. Fujii ◽  
...  
Keyword(s):  
Balloon Experiment

A CdTe Position Sensitive Detector for a Hard X-and Gamma-Ray Wide Field Camera

1997 ◽  
Vol 487 ◽  
Author(s):  
E. Caroli ◽  
G. Bertuccio ◽  
G. De Cesare ◽  
A. Donati ◽  
W. Dusi ◽  
...  
Keyword(s):  
Energy Range ◽  
Gamma Ray ◽  
Basic Element ◽  
Medium Size ◽  
Electromagnetic Spectrum ◽  
Wide Field ◽  
Cdte Detector ◽  
Important Region ◽  
Expected Performance ◽  
Position Sensitive

AbstractAn important region of the electromagnetic spectrum for astrophysics is the hard X- and gamma ray band between 10 keV and a few MeV, where several processes occur in a wide variety of objects and with different spatial distribution and time scales. In order to fulfill the observational requirements in this energy range and taking into account the opportunities given by small/medium size missions (e.g. on the ISS), we have proposed a compact, wide field camera based on a thick (1 cm) position sensitive CdTe detector (PSD). The detector is made of an array of 128×96 CdTe microspectrometers with a pixel size of 2×2 mm2. The basic element of the PSD is the linear module that is an independent detection unit with 32 CdTe crystals and monolithic front-electronics (ASIC) supported by a thin (300 μm) ceramic layer. The expected performance of the PSD over the operative energy range and some of the required ASIC functionality are presented and discussed.

Vibration control using a beam-like adaptive tuned vibration absorber with an actuator-incorporated mass element

2009 ◽  
Vol 223 (7) ◽  
pp. 1555-1567 ◽  
Author(s):  
P Bonello ◽  
K H Groves
Keyword(s):  
Vibration Control ◽  
Effective Mass ◽  
Tuning Range ◽  
Excitation Frequency ◽  
Vibration Absorber ◽  
Time Varying ◽  
Additional Advantage ◽  
Expected Performance ◽  
Vibration Attenuation ◽  
Tuned Vibration Absorber

An adaptive tuned vibration absorber (ATVA) can retune itself in response to a time-varying excitation frequency, enabling effective vibration attenuation over a range of frequencies. For a wide tuning range the ATVA is best realized through the use of a beam-like structure whose mechanical properties can be adapted through servo-actuation. This is readily achieved either by repositioning the beam supports (‘moveable-supports ATVA’) or by repositioning attached masses (‘moveable-masses ATVA’), with the former design being more commonly used, despite its relative constructional complexity. No research to date has addressed the fact that the effective mass of such devices varies as they are retuned, thereby causing a variation in their attenuation capacity. This article derives both the tuned frequency and effective mass characteristics of such ATVAs through a unified non-dimensional modal-based analysis that enables the designer to quantify the expected performance for any given application. The analysis reveals that the moveable-masses concept offers significantly superior vibration attenuation. Motivated by this analysis, a novel ATVA with actuator-incorporated moveable masses is proposed, which has the additional advantage of constructional simplicity. Experimental results from a demonstrator correlate reasonably well with the theory, and vibration control tests with logic-based feedback control demonstrate the efficacy of the device.

scholarly journals 378 Making-Do When Big Data Isn’t Big Enough: Limitations and pathways of possible development in the prediction of Thoroughbred racing performance as a breeding outcome

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 140-143
Author(s):  
Roger E Lyons
Keyword(s):  
Genetic Resources ◽  
Statistical Data ◽  
Statistical Significance ◽  
Market Demand ◽  
Real World Data ◽  
Positive Effects ◽  
Racing Performance ◽  
Expected Performance ◽  
The Subject ◽  
Thoroughbred Racing

Abstract A performance genetics model adapted to real-world data of Thoroughbred racing and breeding will be presented. The continuity of ancestry and performance is documented in the annals of pedigree, not as functional counterparts, but as corresponding signs of market value. Pedigree invites chronic misprision of highly diverse genetic resources competing for scarce opportunity in the racing economy, resulting in samples that are often small and of dubious composition. Data is specialized for competing “pedigree analysis” that packages the system of signification to meet market demand for meaning. Given statistical deficits, this data is a necessary inferential asset of the model. The model’s premise is that predictability is optimized if racing performance is defined as the function of an indivisible relation between parents. Statistical data consists of 6-generation ancestries of mares that produced offspring by a subject stallion. Comparison of proportions is used to identify effects resulting from his relation to individual ancestors of the subject mare. Expected performance by the sire’s offspring is defined as the proportion of mares that produced a superior runner by him. Each ancestor of a subject mare also has descendants among the mares that produced offspring by the stallion. For each of those groups, the proportion of mares that produced a superior runner is compared with the stallion’s expected performance using a t-test of statistical significance at the .10 level. Probable effect is further tested by case study involving such variables as racing class, generational distance, sex-linkage, inbreeding, and an ancestor’s pattern of effect across the stallion population. Stallions with the highest prevalence of positive effects are preferred for the subject mare. This model, under the trade name LyonScore®, has been used since 2012 by Werk Thoroughbred Constultants, Inc. as a component of its client services. Table 1: The data, listed in tabular format below, is graphically displayed for actual use on an ancestry tree whose nodes are numbered by relation to a subject mare (“Position”). Each statistical data item in the table is derived from the stud record of a stallion named Distorted Humor and corresponds with an ancestor of a mare named Positively Royal. Each ancestor of this mare is also an ancestor of a group of mares that produced offspring of Distorted Humor and were at least three years of age as of 2019. A proportion of each of those groups of mares produced at least one superior runner. Proportions that differ significantly from Distorted Humor’s expected proportion are so indicated. Only ancestors involving a group of at least 18 mares are considered to have inferential value on statistical grounds. Table 2: The sire Danzig is an ancestor of Positively Royal, along with 75 mares that produced foals by Distorted Humor, only five of which produced a superior runner by him, significantly fewer than expected. However, since Distorted Humor’s dam is by Danzig, the question of generational distance is relevant as a variable to the effect of inbreeding. The table below shows Danzig’s proportional distribution by genetic relation to those 75 mares as indicated by “Position.” Of the 64 mares in descent of Danzig within three generations, three mares produced a superior runner. It’s notable, though, that 2 of 6 mares with the same relation to Danzig as Positively Royal produced superior runners. Since Danzig is the only ancestor with a negative effect, further consideration is warranted. Table 3: In a population that tends to slough off unprofitable genetic resources, overspecialization is the main risk of close inbreeding. Some generational variations of an ancestor’s contribution can turn inbreeding to less specialized effect, but this depends on generational distance. Distorted Humor’s earliest opportunity with mares in descent of Danzig involved offspring closely inbred to Danzig, but later in his career he encountered mares for which variation was more likely. As the table shows, two of six mares descending from Danzig in position 25 (4th generation) produced Distorted Humor’s best runners inbred to Danzig, so it is of some interest that Positively Royal, the subject mare, is also a postion-25 descendant of Danzig. However, that those two mares happen to be full sisters whose breeding has little else in common with that of Positively Royal leaves the question of Distorted Humor’s fitness for this mare less certain than would be preferred.

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